Ford will build just 300 units of the special truck.
It is based on the F-150 XLT with the chrome package and is available in Oxford White or Blue Flame, in a nod to the team's colors.
The truck also includes special MVP badging, unique polished stainless rocker panels and a spray-in bedliner.
Complete pricing was not available immediately, but Ford spokeswoman Jessica Enoch told Edmunds buyers should expect to pay in the "mid-$40s, plus a $1,195 destination charge."
"The 2016 Ford F-150 MVP edition started as an idea from Marc Lassalle, a Kansas City Royals fan, to celebrate his team's second world championship," Ford said in a statement. "It follows the 1986 Ford Ranger MVP edition, created and sold in 1985 to celebrate Kansas City's first time as world champions."
The F-150 MVP edition trucks are built at Ford's Kansas City Assembly Plant.
Edmunds says: These trucks are bound to score with baseball fans, so it's best to get the conversation going with your Kansas City area Ford dealer now.