2006 Lexus IS 350 Review
Price Estimate: $874 - $1,403





+14
Edmunds' Expert Review
by the Edmunds Experts
Pros
- Immensely confident, highly refined, class-leading interior quality, advanced safety technology.
Cons
- Intrusive safety technology hinders driver enjoyment, cramped rear-seat space.
What’s new
For 2006, Lexus debuts the all-new IS 350. Replacing the previous IS 300, the IS 350 brings forth new powertrains, more features and a higher-quality cabin.
Edmunds says
The 2006 Lexus IS 350 is an outstanding luxury sedan, but it has too many electronic nannies to be a great sport sedan. If you place performance over luxury, test-drive the competition before deciding on this Lexus car.
For sale near West Chicago, IL
13 listings
- 155,813 miles
- Issue reported, 3 owners, personal use only
- 19 City / 26 Hwy MPG
- Majeski Motors of Sterling (76 mi away)
- Leather Seats
- Sunroof/Moonroof
- Power Driver Seat
- Tire Pressure Warnin...
- Multi-Zone Climate C...
Close
Located in Sterling, IL
At Majeski Motors we now offer 3 great locations to serve you better than ever before in Sterling, Dixon and Sycamore! With over 350 vehicles in stock...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Issue reported
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
21 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: JTHBE262962000962
Stock: 11661C
Certified Pre-Owned: No
Listed since: 06-24-2025- 267,000 miles
- No accidents, 1 owner, personal use only
- 19 City / 26 Hwy MPG
- Front Porch Motors (611 mi away)
- Leather Seats
- Sunroof/Moonroof
- Power Driver Seat
- Tire Pressure Warnin...
- Multi-Zone Climate C...
Close
Located in Conyers, GA
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
21 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: JTHBE262665007673
Stock: 7673
Certified Pre-Owned: No
Listed since: 06-26-2025
Vehicle overview
Since 2001, the Lexus IS 300 has taken on the 3 Series with marginal success. Although it never really lit up the sales charts, the rear-wheel-drive IS 300 has earned a small but loyal -- and young -- following. When it came time to create the second generation of the IS, Lexus had to design a sedan with expanded performance and higher interior quality to combat the ever dominant competition. A tall order, but we think Lexus may have pulled it off. The new IS 350 sedan is larger, more luxurious and much more powerful than the previous generation Lexus car.
Since Lexus already had an excellent rear-drive platform in the recently redesigned GS, it became the starting point for the new IS 350. By carving out 4.7 inches of the GS's wheelbase and lopping off 4.4 inches of front and rear overhang, Lexus had the basic structure of the new IS. The GS's double-wishbone front and independent multilink rear suspension moves intact to the IS 350 and is retuned for the new application. The IS 300's straight six has been replaced by an all-aluminum 60-degree, DOHC, 24-valve V6. The 3.5-liter engine features VVT-i variable valve timing and offers 306 horsepower. Also coming from the GS is the suite of electronic technologies -- traction control, stability control, Electronic Brakeforce Distribution and BrakeAssist -- that Lexus groups together as the "Vehicle Dynamics Integrated Management" (VDIM for acronym lovers). VDIM is standard on the IS 350.
The VDIM system makes the Lexus IS 350 a truly fearless and capable high-speed conveyance, but the inability to disable it is troublesome; the system is intrusive enough to dull the pleasure of the car's outstanding engine, great chassis and spectacular brakes. If you prefer your sport sedans serene over spirited and unperturbed over unabashed, then the 2006 Lexus IS 350 could be your ideal car. But if visceral performance is more your thing, check out the 3 Series and G35 before putting your money on the table.
Performance & mpg
The Lexus IS 350 is powered by a 3.5-liter V6. It's rated at an impressive 306 hp at 6,400 rpm and a chunky 277 lb-ft of torque at 4,800 rpm. The engine drives the rear wheels through a six-speed automatic transmission that the driver can control with a steering wheel-mounted paddle shifter.
Safety
Safety equipment includes front and rear side curtain airbags and front seat-mounted side airbags. Also standard is the suite of electronic technologies -- traction control, stability control, Electronic Brakeforce Distribution, BrakeAssist and conventional antilock brakes -- that Lexus groups together as the "Vehicle Dynamics Integrated Management" (VDIM). Optional is a Pre-Collision System (PCS) -- packaged with Dynamic Radar Cruise Control -- that uses a millimeter-wave radar sensor to detect obstacles in front of the car. If the computer determines that a collision is unavoidable it preemptively stiffens the suspension, retracts the front seatbelts and pre-initializes BrakeAssist so increased braking is applied the instant the brake pedal is depressed. In crash tests, the IS earned a "Good" rating (the best possible) for its performance in IIHS frontal offset and side-impact testing.
Driving
With more than 300 hp, a great chassis and spectacular brakes, the 2006 Lexus IS 350 is an undeniable performance car. There's no discernable exhaust note, but it builds speed easily, the chassis is tenacious, and if there isn't going to be a manual transmission around, at least the paddles add some involvement to the driving experience. Still, there's so much technology aboard the Lexus car, the driver is too insulated from the experience. The biggest downer is the inability to disarm the VDIM system, which mutes the sedan's performance long before the limits of its chassis and tires are reached.
Interior
The new Lexus IS 350 boasts impressive interior materials, an attractive cabin design and plenty of luxury amenities. Everything from the soft-touch dash and door panels to the supple leather seats exudes high quality. Rear seating isn't as palatial; the wheelbase is 1.2 inches shorter than the new 3 Series and offers minimal rear legroom. If you regularly carry adults -- or even large children -- in the rear seat, they won't be happy back there.
2006 Lexus IS 350 models
The Lexus IS 350 sedan comes in just one trim level. The standard features list includes keyless entry and ignition, tilt and telescoping steering wheel, power doors and windows, cruise control, leather seating, an auto-dimming rearview mirror, a moonroof and a 13-speaker premium audio system with an in-dash six-disc CD changer. Options include a 14-speaker Mark Levinson audio system, 18-inch wheels, 10-way power seats, a navigation system, Dynamic Radar Cruise Control (which allows drivers to set a preferred interval between the IS and traffic ahead), rear park assist, rain-sensing wipers, corner-adaptive headlamps, Bluetooth connectivity and bi-HID headlights.
Compare 2006 Lexus IS 350 trim levels
Helpful trims summary and side-by-side comparison chart

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Cost to Drive
Monthly estimates based on costs in Illinois
$255/mo for IS 350 Base
IS 350 Base
vs
$179/mo
Avg. Compact Car
See Edmunds pricing data
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Lexus IS 350 Owner Reviews
Most Helpful Owner Reviews
Trending topics
Buying Another IS 350
5 out of 5 starsJoshY, 06/23/2010
2006 Lexus IS 350 4dr Sedan (3.5L 6cyl 6A)
Leased IS 350 for 4 years starting in 2006. Loved this car. Gave it back in expectations of moving to Mercedes or BMW. Test drove 328,335 and C class, and immediately missed my 350's acceleration. Can't beat its value for horsepower, handling, looks. Had no issues with it. Drove it 52,000 miles. Loved it just as much after 4 years.Awesome power yet handled very well for city driving. … Would not recommend for tall people, I'm 5'10. Backseat is decent, but don't use. I'm buying either a '06, '07 again. Adding navi, bluetooth, heated/cooled seats in next one.
Best car we have ever owned!
5 out of 5 starsThomas Bergschneider, 05/26/2018
2006 Lexus IS 350 4dr Sedan (3.5L 6cyl 6A)
Being married for 41 years ,I normally get my wife a new car every 3 years. She loves this car so much she still drives it. Other than a battery and tires the car has not required anything but normal service and a couple of minor recalls. I have gotten 31mpg on the highway at 70 mph. The brakes are excellent and are original. When warranty service was required, my wife was always given a … new car to use while service was being completed. I give this car a 10 out of 10 after 12 years of ownership.
Featuristic!
5 out of 5 starsLaMario, 10/18/2010
2006 Lexus IS 350 4dr Sedan (3.5L 6cyl 6A)
I was an Acura TL guy until I went to the Acura Dealership and they didn't have the TL I wanted. I saw an IS350 on the lot and when I checked it out, not even the Acura RL compared to the features of my IS350. I was amazed at this car when I first sat in one and it even had the Acura salesperson in awe. I also loved the Mercedes C and E Class but it is not as fun to drive as my IS350 and … is a more complicated to use their features. My IS350 has a very quiet engine which makes for a smoother ride. Compared to other cars I've had or driven, my Lexus IS350 is very user friendly, stylish, fun to drive, and just plain AWESOME!
MAJOR fun car, minor complaints
4.88 out of 5 starstjp, 02/27/2009
2006 Lexus IS 350 4dr Sedan (3.5L 6cyl 6A)
I'm approaching my third year anniversary with my IS350, and it's still the best purchase I've ever made. Passengers still get in and say "wow". But after three years you realize there are a few little things that you would change if you could. Warning: What follows are complaints that in NO WAY would cause me to not buy another IS350. I love this car in every way, shape and form. I … still pinch myself that I own a car this amazing. Okay, disclaimer over, read on...
2006 IS 350 Highlights
Base MSRP Excludes Destination Fee | $35,440 |
---|---|
Engine Type | Gas |
Combined MPG | 21 MPG |
Cost to Drive | $255/month |
Seating | 5 seats |
Cargo Capacity All Seats In Place | 13 cu.ft. |
Drivetrain | rear wheel drive |
Warranty | 4 years / 50,000 miles |
Safety
Key safety features on the IS 350 include:
- Alarm
- Tire Pressure Warning
- Stability Control
IIHS Rating
The Insurance Institute of Highway Safety uses extensive crash tests to determine car safety.
- Small Overlap Front Driver-Side TestNot Tested
- Small Overlap Front Passenger-Side TestNot Tested
- Moderate Overlap Front Test – OriginalGood
- Moderate Overlap Front Test – UpdatedNot Tested
- Side Impact Test – OriginalGood
- Side Impact Test – UpdatedNot Tested
- Roof Strength TestNot Tested
- Rear Crash Protection / Head RestraintAcceptable
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