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$32,979great price$10,269 below market- 52,693 miles
- 20 City / 28 Hwy MPG
- Woodbridge, VA
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Located in Woodbridge, VA / 882 miles away from Des Moines, IA
This 2021 Lexus IS 350 F SPORT, with 52,693 miles, offers a thrilling opportunity to own a sporty, head-turning luxury sedan that masterfully combines...
- Features and Specs:
- 23 Combined MPG (20 City/28 Highway)
- Listing Information:
- VIN:
- JTHGZ1B20M5039588
- Stock:
- 039588
- Certified Pre-Owned:
- No
- Listed since:
- 07-15-2026
- New Listing
$37,990great price$4,662 below market- 52,826 miles
- 20 City / 28 Hwy MPG
- In-stock online
- Delivery available*
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Located in Sacramento, CA / 1,485 miles away from Des Moines, IA
At Carvana, we go miles beyond the extra mile. That's why we provide you with a convenient, fast, and hassle-free car buying experience that puts you ...
- Features and Specs:
- 23 Combined MPG (20 City/28 Highway)
- Listing Information:
- VIN:
- JTHGZ1B26M5041197
- Stock:
- 3006898044
- Certified Pre-Owned:
- No
- Listed since:
- 10-24-2026
- New Listing
$32,990great price- 92,311 miles
- 19 City / 26 Hwy MPG
- In-stock online
- Delivery available*
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Located in Dallas, TX / 634 miles away from Des Moines, IA
At Carvana, we go miles beyond the extra mile. That's why we provide you with a convenient, fast, and hassle-free car buying experience that puts you ...
- Features and Specs:
- 22 Combined MPG (19 City/26 Highway)
- Listing Information:
- VIN:
- JTHGZ1E20M5019322
- Stock:
- 3006682865
- Certified Pre-Owned:
- No
- Listed since:
- 10-02-2026
- Price Drop
$36,673good price$4,101 below market- 28,052 miles
- 20 City / 28 Hwy MPG
- Hadley, MA
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Located in Hadley, MA / 1,076 miles away from Des Moines, IA
2021 Lexus IS 350 F SPORT Ultra White 3.5L V6 DOHC Dual VVT-i 24V 8-Speed Automatic 20/28 City/Highway MPGClean AutoCheck, AM/FM/CD Player, Automatic...
- Features and Specs:
- 23 Combined MPG (20 City/28 Highway)
- Listing Information:
- VIN:
- JTHGZ1B22M5038281
- Stock:
- VW13402AB
- Certified Pre-Owned:
- No
- Listed since:
- 09-26-2026
$35,990good price$2,984 below market- 77,453 miles
- 19 City / 26 Hwy MPG
- Maplewood, MN
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Located in Maplewood, MN / 238 miles away from Des Moines, IA
Caviar 2021 Lexus IS 350 F SPORT New Tires, 350 F SPORT, AWD, Caviar, Black W/Ginsumi Premium Synthetic. Family owned and operated since 1972 Kline Vo...
- Features and Specs:
- 22 Combined MPG (19 City/26 Highway)
- Listing Information:
- VIN:
- JTHGZ1E24M5018772
- Stock:
- RV12528A
- Certified Pre-Owned:
- No
- Listed since:
- 10-15-2026
- Price Drop
$33,999good price$3,067 below market- 51,159 miles
- 20 City / 28 Hwy MPG
- Coconut Creek, FL
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Located in Coconut Creek, FL / 1,303 miles away from Des Moines, IA
2021 Lexus IS 350 F SPORT Grecian Water Accessory Package (Cargo Net, Carpet Trunk Mat, Key Gloves, and Wheel Bolt Locks), 350 F SPORT, White W/Black ...
- Features and Specs:
- 23 Combined MPG (20 City/28 Highway)
- Listing Information:
- VIN:
- JTHGZ1B20M5043057
- Stock:
- X146196A
- Certified Pre-Owned:
- No
- Listed since:
- 09-29-2026
- New Listing
$27,494good price$2,609 below market- 109,351 miles
- 19 City / 26 Hwy MPG
- Henderson, NV
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Located in Henderson, NV / 1,215 miles away from Des Moines, IA
Welcome to Findlay Honda in Henderson. All of our cars are hand picked and inspected for your peace of mind. This IS is equipped with the following op...
- Features and Specs:
- 22 Combined MPG (19 City/26 Highway)
- Listing Information:
- VIN:
- JTHGZ1E28M5022694
- Stock:
- H264087A
- Certified Pre-Owned:
- No
- Listed since:
- 11-07-2026
$37,998fair price$1,003 above market- 60,020 miles
- 19 City / 26 Hwy MPG
- In-stock online
- Transfer available*
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Located in Bogart, GA / 762 miles away from Des Moines, IA
Wanna drive? CarMax puts you in the driver's seat-and that includes transparency and pricing without document or processing fees. Certain cars may hav...
- Features and Specs:
- 22 Combined MPG (19 City/26 Highway)
- Listing Information:
- VIN:
- JTHGZ1E20M5021393
- Stock:
- 29142313
- Certified Pre-Owned:
- No
- New Listing
$36,594great price$4,348 below market- 71,135 miles
- 20 City / 28 Hwy MPG
- Las Vegas, NV
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Located in Las Vegas, NV / 1,221 miles away from Des Moines, IA
Dynamic Handling PackageNavigation Package W/Mark Levinson AudioIntuitive Park Assist W/Panoramic View MonitorTriple-Beam Led HeadlampsMoonroofSu...
- Features and Specs:
- 23 Combined MPG (20 City/28 Highway)
- Listing Information:
- VIN:
- JTHGZ1B24M5041120
- Stock:
- M5041120
- Certified Pre-Owned:
- No
- Listed since:
- 11-05-2026
$43,720fair price- 14,731 miles
- 20 City / 28 Hwy MPG
- San Antonio, TX
- Five Star Dealer
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Located in San Antonio, TX / 879 miles away from Des Moines, IA
Certified. L-CERTIFIED, Apple CarPlay/Android Auto, F SPORT NuLuxe Seat Trim, Heated & Ventilated F Sport Sport Seats, Intuitive Park Assist w/Auto Br...
- Features and Specs:
- 23 Combined MPG (20 City/28 Highway)
- Listing Information:
- VIN:
- JTHGZ1B22M5046901
- Stock:
- L5046901
- Certified Pre-Owned:
- Yes
- Listed since:
- 10-23-2026
- Price Drop
$36,627fair price$472 below market- 43,022 miles
- 20 City / 28 Hwy MPG
- Naples, FL
- Five Star Dealer
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Located in Naples, FL / 1,251 miles away from Des Moines, IA
This 2021 Lexus IS 350 F SPORT sedan delivers premium performance and luxury in a stunning white exterior with white and black interior. With its pote...
- Features and Specs:
- 23 Combined MPG (20 City/28 Highway)
- Listing Information:
- VIN:
- JTHGZ1B2XM5045480
- Stock:
- L261732A
- Certified Pre-Owned:
- No
- Listed since:
- 10-16-2026
$35,484fair price$1,282 above market- 68,010 miles
- 20 City / 28 Hwy MPG
- Fontana, CA
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Located in Fontana, CA / 1,399 miles away from Des Moines, IA
Experience the thrill of the 2021 Lexus IS 350 F SPORT, featuring a potent 3.5L 311-HP V6 engine and F SPORT Suspension Tuning for an exhilarating dri...
- Features and Specs:
- 23 Combined MPG (20 City/28 Highway)
- Listing Information:
- VIN:
- JTHGZ1B24M5042963
- Stock:
- M5042963
- Certified Pre-Owned:
- No
- Listed since:
- 09-25-2026
- Price Drop
$41,710fair price$1,597 above market- 27,145 miles
- 20 City / 28 Hwy MPG
- Las Vegas, NV
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Located in Las Vegas, NV / 1,216 miles away from Des Moines, IA
Priced below KBB Fair Purchase Price!Infrared 2021 Lexus IS 4D Sedan 350 F SPORT RWD 8-Speed Automatic 3.5L V6 DOHC Dual VVT-i 24V White W/Black Pre...
- Features and Specs:
- 23 Combined MPG (20 City/28 Highway)
- Listing Information:
- VIN:
- JTHGZ1B20M5041101
- Stock:
- G10043E
- Certified Pre-Owned:
- No
- Listed since:
- 10-27-2026
- New Listing
$37,998fair price$409 above market- 52,110 miles
- 20 City / 28 Hwy MPG
- In-stock online
- Transfer available*
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Located in Marysville, WA / 1,463 miles away from Des Moines, IA
Wanna drive? CarMax puts you in the driver's seat-and that includes transparency and pricing without document or processing fees. Certain cars may hav...
- Features and Specs:
- 23 Combined MPG (20 City/28 Highway)
- Listing Information:
- VIN:
- JTHGZ1B23M5044865
- Stock:
- 28979937
- Certified Pre-Owned:
- No
$29,988good price$1,062 below market- 96,801 miles
- 20 City / 28 Hwy MPG
- Findlay, OH
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Located in Findlay, OH / 516 miles away from Des Moines, IA
This stunning 2021 Lexus IS 350 F SPORT delivers premium performance and refined luxury in a silver exterior that turns heads. With a powerful 3.5L V6...
- Features and Specs:
- 23 Combined MPG (20 City/28 Highway)
- Listing Information:
- VIN:
- JTHGZ1B29M5037371
- Stock:
- P013129B
- Certified Pre-Owned:
- No
- Listed since:
- 09-14-2026
- Price Drop
$29,752good price$1,328 below market- 122,043 miles
- 20 City / 28 Hwy MPG
- Reno, NV
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Located in Reno, NV / 1,380 miles away from Des Moines, IA
The 2021 Lexus IS 350 F SPORT offers a compelling blend of performance, technology, and luxury. Powered by a 3.5L V6 engine delivering 311 horsepower ...
- Features and Specs:
- 23 Combined MPG (20 City/28 Highway)
- Listing Information:
- VIN:
- JTHGZ1B2XM5041221
- Stock:
- SV7080
- Certified Pre-Owned:
- No
- New Listing
$34,990good price$1,453 below market- 61,300 miles
- 20 City / 28 Hwy MPG
- In-stock online
- Delivery available*
Close
Located in Phoenix, AZ / 1,153 miles away from Des Moines, IA
At Carvana, we go miles beyond the extra mile. That's why we provide you with a convenient, fast, and hassle-free car buying experience that puts you ...
- Features and Specs:
- 23 Combined MPG (20 City/28 Highway)
- Listing Information:
- VIN:
- JTHGZ1B22M5041746
- Stock:
- 3006838885
- Certified Pre-Owned:
- No
- Listed since:
- 11-02-2026
- New Listing
$33,169fair price$319 above market- 74,228 miles
- 20 City / 28 Hwy MPG
- Roseville, CA
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Located in Roseville, CA / 1,470 miles away from Des Moines, IA
At EchoPark, it’s all about offering you options for a happy experience. We have thousands of new-to-you makes and models that range from sedans to tr...
- Features and Specs:
- 23 Combined MPG (20 City/28 Highway)
- Listing Information:
- VIN:
- JTHGZ1B24M5039755
- Stock:
- CM5039755
- Certified Pre-Owned:
- No
- Listed since:
- 10-22-2026
- Price Drop
$35,781fair price$868 above market- 76,191 miles
- 20 City / 28 Hwy MPG
- Beaverton, OR
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Located in Beaverton, OR / 1,482 miles away from Des Moines, IA
2021 Lexus IS 350 F SPORT 4D Sedan Caviar RWD 3.5L V6 DOHC Dual VVT-i 24V 20/28 City/Highway MPGClean CARFAX.White W/Black Premium Synthetic, Acce...
- Features and Specs:
- 23 Combined MPG (20 City/28 Highway)
- Listing Information:
- VIN:
- JTHGZ1B28M5043453
- Stock:
- P043453
- Certified Pre-Owned:
- No
- Listed since:
- 07-24-2026
$28,495good price$748 below market- 145,149 miles
- 19 City / 26 Hwy MPG
- Arlington Heights, IL
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Located in Arlington Heights, IL / 287 miles away from Des Moines, IA
This striking 2021 Lexus IS 350 F SPORT sedan combines refined performance with elegant design. Finished in Silver with a sophisticated black interior...
- Features and Specs:
- 22 Combined MPG (19 City/26 Highway)
- Listing Information:
- VIN:
- JTHGZ1E20M5020289
- Stock:
- AL5494A
- Certified Pre-Owned:
- No
- Listed since:
- 10-06-2026
- Price Drop
$40,344fair price$142 below market- 40,088 miles
- 19 City / 26 Hwy MPG
- Lynnwood, WA
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Located in Lynnwood, WA / 1,467 miles away from Des Moines, IA
Certified. Clean CARFAX. AWD Priced below KBB Fair Purchase Price! 19/26 City/Highway MPG Lexus Certified 161pt. Inspection, AWD, Flare Red W/Black Pr...
- Features and Specs:
- 22 Combined MPG (19 City/26 Highway)
- Listing Information:
- VIN:
- JTHGZ1E20M5020356
- Stock:
- M5020356
- Certified Pre-Owned:
- Yes
- Listed since:
- 10-23-2026
Showing 1 - 21 out of 863 listings
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Consumer Reviews for the Lexus IS 350
Read recent reviews for the Lexus IS 350
2016 IS350 F Sport
Tim, 03/30/2016
2016 Lexus IS 350 4dr Sedan AWD (3.5L 6cyl 6A)
I hesitated to buy this car because of Consumer Reports rating. They did not like the car very much. Later I found their review was based on the entry level IS. My opinion is that this car is awesome. I have owned over fifty cars in my life. I am hard to please. This car accomplishes what it is supposed to do. When you factor in reliability it wins the class with little competition.
FAQ
How does the 2021 Lexus IS 350 compare to its rivals and similar models?
- The 2021 Lexus IS 350 falls short of rivals in interior space and technology refinement, but it rides smoothly, handles nimbly and offers more features for the money than German competitors. Against the Alfa Romeo Giulia, which is the passion purchase in the class, the Audi A4, which is exceptionally well-rounded, and the BMW 3 Series, the IS 350 has a tighter back seat, a smaller trunk and slower acceleration. The Genesis G70 offers a more powerful available turbocharged V6 and a longer warranty.
How fast is the 2021 Lexus IS 350?
- The 2021 Lexus IS 350 accelerated from 0 to 60 mph in 6.2 seconds in Edmunds' rear-wheel-drive test car, which is well off the pace of the class leaders. Edmunds calls its acceleration lackluster for a six-cylinder luxury sedan.
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