We just recently upgraded from a Saturn Vue to the Honda Odyssey. We couldn't be happier with the upgrade. At first the wife was worried about her coolness factor and driving a minivan, but after driving it for a few weeks she is in love with the room and convenience. I like it for the features and handling. On many occasions now I've been driving at highway speeds when a light turns red and I'm worried about stopping in time an was initially surprised that I stopped with no problem and had room to spare. In the Vue, I would have had trouble stopping. The seats are comfortable, everything seems to be of good build quality.
I love the automatic trizone climate control... also like the built in sunscreens on the sliding door for our baby.
Wish they had more color combinations with a darker interior color to make it easier to keep it clean with the kids. The red color we liked outside had the light tan inside which we didn't like.