We bought our Odyssey back in 2005 with 60k miles on it. It now has over 130k miles on it with only minor problems: Check engine light on (oxygen sensor) and paint durability issues sliding rear door problems. It seems a lot of people have this problem. I found that it helped if you lube the movable parts on the door it helps keep it from sticking. As far as the transmission goes, you need to service and change fluid every 15k or 20k miles for reliability. Most people don't do this and they wonder why they have problems. We had the timing belt changed at 100k miles. This van has been on 2 1500 mile trips and 2 1200 mile trips with no issues. The van is a daily driver.
Comfort and fun to drive. Everything still works fine for a 9yr 130k mile vehicle.
improve paint issues and sliding rear window problems