We bought new after owning a Windstar, and looking at Chrysler, Ford and Toyota. Transmission had problems at 600 miles! But the dealer and Honda were all over it, and we had the car back with a new transmission the next day. No problems since, not one. It handles better than any other minivan, no exceptions, and holds more, too. We've taken 2-3 trips per year of 2000+ miles with two kids and a dog, and I wouldn't try that in any other vehicle but this one.
Sharp handling, power, room, folding rear seat.
My only problem with all the storage cubbies and cupholders is my kids fill 'em up with candy wrappers and other trash.