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260 listings
  • Stock photo**
    • 43,187 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Lindsay Lexus of Alexandria (446 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Alexandria, VA / 446 miles away from Charleston, SC

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2YGMDA5NC079909
    Stock: L49981A
    Certified Pre-Owned: No
    Listed since: 07-15-2025

  • New Listing
    • 43,636 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Grand Motorcars (274 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Marietta, GA / 274 miles away from Charleston, SC

    Priced below KBB Fair Purchase Price! 3.5L V6 DOHC VVT-i 24V, AWD, Circuit Red Artificial Leather, Automatic Headlamp Levelling Device, Cold Weather P...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2YGMDA7MC061278
    Stock: MC061278
    Certified Pre-Owned: No
    Listed since: 07-30-2025

  • Price Drop
    $43,749
    fair price
    $588 below market
    • 29,155 miles
    • 1 accident, 1 owner, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Driveway (In-stock online)
    • Home delivery*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Sunroof/Moonroof
    • Keyless Entry/Start
    Close

    Located in Ramsey, NJ / 655 miles away from Charleston, SC

    CarFax 1-Owner,Green Vehicle,Apple CarPlay,Back-Up Camera,Blind Spot Monitor,Bluetooth,Brake Assist,Heated Seats,Heated Steering Wheel,Keyless Start,L...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: No

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA8NC087552
    Stock: L17711T
    Certified Pre-Owned: No

  • New Listing
    Stock photo**
    • 76,150 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Cars Plus (233 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Lenoir, NC / 233 miles away from Charleston, SC

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2JGMDA0NC083481
    Stock: J83481
    Certified Pre-Owned: No
    Listed since: 08-01-2025

  • Price Drop
    • 36,132 miles
    • Issue reported, 2 owners, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Carvana (In-stock online)
    • Home delivery*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Columbus, OH / 524 miles away from Charleston, SC

    At Carvana, we go miles beyond the extra mile. That's why we provide you with a convenient, fast, and hassle-free car buying experience that puts you ...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Issue reported

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA3LC052818
    Stock: 2003872289
    Certified Pre-Owned: No
    Listed since: 07-19-2025

  • New Listing
    • 39,897 miles
    • 5 Seats, 31 City / 28 Hwy MPG
    • CarMax (In-stock online)
    • Transfer available from CA to SC*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Inglewood, CA / 2,205 miles away from Charleston, SC

    CarMax values transparency and wants you to love your next car, not settle on it. Certain vehicles may have unrepaired safety recalls. Check nhtsa.gov...

    AutoCheck Vehicle History Summary Unavailable.

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2YGMDA5LC055607
    Stock: 27192393
    Certified Pre-Owned: No

  • New Listing
    Stock photo**
    • 90,526 miles
    • 5 Seats, 31 City / 28 Hwy MPG
    • Lake Norman Chrysler Jeep Dodge Ram (193 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Keyless Entry/Start
    Close

    Located in Cornelius, NC / 193 miles away from Charleston, SC

    Clean CARFAX 2020 Lexus RX 450h F Sport Performance AWD3.5L V6 DOHC VVT-i 24V, AWD, Circuit Red w/F SPORT NuLuxe Seat Trim or F SPORT Package, F SPORT...

    AutoCheck Vehicle History Summary Unavailable.

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2YGMDA8LC046982
    Stock: 6H6122
    Certified Pre-Owned: No
    Listed since: 07-29-2025

  • New Listing
    Stock photo**
    • 73,249 miles
    • 1 accident, 1 owner, corporate fleet vehicle
    • 5 Seats, 31 City / 28 Hwy MPG
    • Hyundai of Columbia (449 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Columbia, TN / 449 miles away from Charleston, SC

    At Hyundai of Columbia, we re committed to a hassle-free, customer-first experience. If you want a good deal, you ve found it! Optional upgrades are a...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: No

    Personal Use Only: No

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2SGMDA8NC073642
    Stock: H15489
    Certified Pre-Owned: No
    Listed since: 07-23-2025

Showing 253 - 260 out of 260 listings

Consumer Reviews for the Lexus RX 450h

Read recent reviews for the Lexus RX 450h
Overall Consumer Rating
4.6 out of 5 stars47 Reviews
Write a vehicle reviewSee all 47 reviews
  • 5 star
    (81%)
  • 4 star
    (11%)
  • 3 star
    (4%)
  • 2 star
    (2%)
  • 1 star
    (2%)
4 out of 5 stars

Very pleased with this car after nearly 8 years!

Happy Lexus Owner, 04/08/2018
2010 Lexus RX 450h 4dr SUV AWD (3.5L 6cyl gas/electric hybrid CVT)
We bought our RX450h new and have driven it daily since. It is not a car for the performance oriented driver. It is a room, comfortable cruiser that gets impressive gasoline mileage in town. On the highway it is smooth and quiet. The hybrid drive has worked great, and we've had no problems with the system. After 70K miles, I can report only one significant mechanical problem, which could … very well have been catastrophic. An oil hose burst and the car leaked oil all over our garage a driveway. Fortunately, I discovered it in time before the car was driven a significant distance. The local Lexus dealer replaced it for free. This was not an isolated incident with the model... there are quite a few similar cases posted on internet forums. Why the Lexus dealer didn't recall and replace it earlier is a mystery. If you own this car or buy one used, make sure your mechanic checks all of the oil hoses! Otherwise, it's a great (if boring) car. We will pass it down to our teenage daughter soon.
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Used 2022 Lexus RX 450h in Charleston, SC Values

Estimated values
2022 Lexus RX 450h F SPORT Handling 4dr SUV AWD (3.5L 6cyl gas/electric hybrid CVT) with no options
ConditionTrade-InPrivate PartyDealer Retail
Outstanding$36,713$38,651$40,672
Clean$36,224$38,116$40,087
Average$35,408$37,224$39,113
Rough$34,349$36,064$37,846

The average list price of a used 2022 Lexus RX 450h in Charleston, South Carolina is $42,418. The average mileage on a used Lexus RX 450h 2022 for sale in Charleston, South Carolina is 53,992. Based on the average mileage of 53,992 for used 2022 Lexus RX 450h for sale in Charleston, SC and using an average vehicle condition rating, which means the vehicle may have a few mechanical and/or cosmetic problems and may require a considerable amount of reconditioning, we appraise the average trade-in value of a used Lexus RX 450h 2022 in Charleston, South Carolina to be $35,408.

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* Delivery of any kind does not apply to Alaska and Hawaii. Contact the dealer for delivery details, restrictions and costs.