My husband and I researched for about a month...we looked at a Sequoia, Sienna, Nissan Pathfinder, 4Runner, Highlander, Pilot, and LX570. In the end, we settled on a Sequoia SR5, 4x4 with a package upgrade that included leather and other useful amenities. It didn't seem to us that an upgrade to the Limited trim was worthwhile for what is added, and the platinum trim was more than what we wanted to spend.
We chose the Sequoia because it really has it all. Great 4x4 system to get through the winter safely. A very roomy and comfortable cabin for our family of 5. A full sized spare tire for peace of mind. The right amount of amenities. Good comfortable ride. Reliability. It does cost a good chunk of change, and the gas mileage isn't great. However, if you are worried about that you probably aren't looking for a full sized SUV.
I don't know why Toyota doesn't push these more. We drove so many cars and this blows them all out of the water. You can't go wrong with a Sequoia! The turning radius is super for a car this size.
The extra foot -bumper to bumper, compared to the 4-runner was too much for me. The interior was largely a step down from previous year's. The v-8 had a lot of power and delivered acceleration. Road noise was high.