Used 2021 Mercedes-Benz E-Class Sedan Trims Comparison

E 350
The sedan-only E 350 is powered by a turbocharged 2.0-liter four-cylinder (255 horsepower, 273 lb-ft of torque) paired with a nine-speed automatic transmission. Rear-wheel drive is standard and all-wheel drive (4Matic) is available. Standard feature highlights include:

• LED headlights
• Simulated leather upholstery (MB-Tex)
• Power-adjustable and heated front seats
• Dual-zone automatic climate control
• Sunroof
• 12.3-inch touchscreen infotainment display
• MBUX infotainment interface
• Digital instrument cluster
• Apple CarPlay and Android Auto smartphone integration
• Keyless entry with push-button start
• Automatic emergency braking (warns if a front impact is imminent and applies the brakes if you don't respond in time)
• Blind-spot monitor (alerts you if a vehicle in the next lane over is in your blind spot)

Noteworthy options on the E-Class sedan include:

• Larger wheels
• Air suspension (can raise or lower the ride height of the vehicle)
• Augmented video for easier navigation prompts
• MBUX Interior Assistant (can operate controls with hand gestures)
• Head-up display
• Surround-view camera (gives you a top-down view of the E-Class and its surroundings for tight parking situations)
• Adaptive headlights (swivel as you turn the steering wheel for better illumination in curves)
• Premium Burmester audio system
• Leather and premium leather upholsteries
• Wireless charging pad 
• Panoramic sunroof
• Ventilated front seats
• Massaging front seats
• Driver Assistance package
• Adaptive cruise control (adjusts speed to maintain a constant distance between the vehicle and the car in front)
• Active steering assist (works with adaptive cruise control to keep the car centered in the lane, even around gentle curves)
• Lane departure warning (alerts you if the vehicle begins to drift out of its lane)
• Blind-spot monitor with rear cross-traffic alert (warns you if a vehicle is in your blind spot during a lane change or while reversing)

E 450
The E 450 is available as a sedan, coupe, convertible and the All-Terrain wagon. The coupe and convertible come standard with rear-wheel drive; all-wheel drive (4Matic) is optional on those and standard on the sedan and wagon. Mercedes is calling the 2021 E 450 wagon the All-Terrain. It's the same general design as in prior years but now has plastic fender body cladding and a slightly higher ride height.

All E 450s are powered by a turbocharged 3.0-liter six-cylinder engine paired to a mild hybrid system (362 hp, 369 lb-ft) mated to a nine-speed automatic transmission. Standard and optional features of the E 450 are similar to those of the E 350.

AMG E 53
Mercedes offers two performance variants of the E-Class. The AMG E 53 is available as a sedan, coupe or convertible. They have the turbocharged six-cylinder engine but here it makes 429 hp and 384 lb-ft. All E 53 models come with a sport-tuned all-wheel-drive system. Standard features mirror those on the E 450 models but add a few AMG-specific touches such as a sport-tuned air suspension and special wheels and exterior styling.

AMG E 63
The range-topping AMG E 63 is a brute, powered by a turbocharged 4.0-liter V8 (603 hp, 627 lb-ft) that sends power to all four wheels through a specially designed nine-speed automatic transmission. The AMG E 63 is only available as a sedan or wagon. Features build on the AMG E 53, adding even more performance-tuned goodies such as:

• 20-inch wheels
• Upgraded suspension tuning
• AMG exhaust
• AMG-specific MBUX functions
• Standard AMG Track Pace app

Options on the E 63 include options available on the E 53 plus:

• Carbon-fiber trim package
• Carbon-ceramic brakes for improved braking performance