I bought my 2006 used in 2011 with 75K miles. Since then it needed new e-brake lines, front coils (broken), front disks, new exhaust (not surprising), hesitated when cold, and repairs for rear hub gaskets, ball joints, etc. to the tune of 7K in repairs. Rarely got better than 10 MPG around town. I put less that 20K on this in 3 years. Good looking, well laid-out truck, but not reliable.
Owned this truck for 7 years and had many problems with it. There were also many recalls. Looks nice but not very tough. Nissan also did not help me out when needed. I was a Nissan owner for 20 years (Pathfinder & Exterra before the Titan) but because of Nissan not caring about my problems I have now switched to Toyota.