I bought my 2006 used in 2011 with 75K miles.
Since then it needed new e-brake lines, front coils (broken), front disks, new exhaust (not surprising), hesitated when cold, and repairs for rear hub gaskets, ball joints, etc. to the tune of 7K in repairs.
Rarely got better than 10 MPG around town.
I put less that 20K on this in 3 years.
Good looking, well laid-out truck, but not reliable.
Owned this truck for 7 years and had many problems with it. There were also many recalls. Looks nice but not very tough. Nissan also did not help me out when needed. I was a Nissan owner for 20 years (Pathfinder & Exterra before the Titan) but because of Nissan not caring about my problems I have now switched to Toyota.
I purchased the 2006 base XE model TITAN with the Big Tow package. By far, this truck has had no problems. The previous years-like 04 rotor warping, or first year bugs- were not found in this truck. 27,000 miles and counting, this truck has had zero problems! The acceleration, handling, and reliability show that Nissan did their homework on this truck and broke the barrier of the 1/2 ton rut the Big Three have traditionally made. Styling keeps the truck distinct, 5 speed tranny knows which gear to shift to, the 5.6L V8 with its underrated 305hp gives a Hemi a kick in the pants, and the simplicity inside the truck doesn't make the truck boring-but not over done.