Amazing reliability...keep the oil changed regularly, the tires inflated and the gas tank filled, this "drives-like-a-car" minivan will take you further and longer for less. Tremendous cargo space is available when needed; the foldup-slide forward middle seat opens up a sumptuous cavern that has moved its share of tonnage. The V-6 engine is a peppy road burner, yet still delivers 22-26 mpg on the highway after 150K miles, if you have the proper foot for it.
I had no problems with my Quest except for normal wear and tear. I've heard of them Rolling in the dessert and everyone being ok. I know from experience how it handles in a wreck and I'm pround of it. I love this car!
My manifold bolts went at 75K, and though I was "told" at the dealership that it was after warranty, it was also made clear to me that "you might want to call Nissan and tell them about your unhappiness." It helped. They covered several hundred dollars of the work that I had done. It is ridiculous for the bolts to go at that mileage; this was obviously one of those "hidden recalls." Otherwise, my experience mirrors that of others: water pump at 109K (I did timing belt then, too), but otherwise it runs and runs. It will be ten years this fall, and--knock on wood--I'll get another 5 years/50K. Finish has held up well through loits of snow/salt.
A great car that has really lasted and done fine service--but the manifold/header bolts went, front and back, around 80K. I found out through the dealer that a call to Nissan might get some help, and they did volunteer to pay almost half the cost, but it was still plenty expensive. Other than that, I like the car a great deal and plan to drive it until it simply falls apart.