This is the third car that I owned that I have put on over 250 k miles. This is by far the most reliable, it has never broke down. Only repairs are normal wear and tear such as tires, brakes, rear bearings and plugs/ignition coils.
I recently picked up a 2007 RX350 I purchased from Carmax. The SUV has 68k mikes and looked to be in good shape. Since you only have 30 days with Carmax to request repairs (I opted out of their exctended warranty), I took it to my local auto mechanic for a "once over". The mechanic found that the rack and pinion as well as the rear struts were leaking. I drove about an hour an a half back to Carmax in PA for what I thought would be a battle over the repairs. Much to my surprise, the confirmed the leaks and said they would order the parts and replace them. No problem. Hopefully that all works out.
This car is a smooth drive and very reliable. I am a very short person and the adjustable seats are very comfortable and allows me to feel in complete control of the car while driving. I bought this car pre-owned and at 100,000 miles the engine still runs and looks as if brand new. The design is sleek and smooth and I feel very safe behind the wheel of this RX 350.
Wanted to drive the suv for a year before stating my opinion. Traded in a 03MDX (transmission torque converter issue @ 96K miles), and opted for a used 07LexusRX vs new Subaru Outback - $9k cheaper. Overall I am pleased with my purchase, as the car was a premium package w/Nav etc. I agree the Nav is a pain to use because of its limited ability to change while on the move (other than voice commands, which is even more frustrating and distraction when it doesn't recognize what you are saying) than being able to input by touch. Only isuue so far... rear wheel bearing hub which was replaced under warranty (70k Miles for drivetrain) which the dealer promptly notified me. So far so good!
When I decided to upgrade my 'flawless' 1998 Toyota 4-Runner, the RX 350 was a 'no-brainer'. A lot more luxurious, more class and good looks coupled with Toyota's solid reputation made the decision easy. Overall I like it. Ride, fuel-mileage, luxury are right up there. However, the Nav System that is 'voice-activated' comes up short. What really hurts however is that the 'RX' series doesn't include recognition of any 'Climate Commands'. All of the other Lexus models do. I called Lexus/USA about this. A 10 second download would fix the problem. Their answer - 'Sorry - No Deal'. It makes you feel that you have less of a Lexus than the other models. Why??