This is the third Ford truck I've owned and they just keep getting better. Even the wife loves it (and drives it). The handling is smooth. Rides like a car but works like a truck. Suspension is firm but not bumpy. Corners tight (for a truck) and looks pretty when it's clean. Gas mileage is decent for its size and the interior is nice, quiet and has everything I need. Never had trouble with the old one (1994) and the way I follow the routine scheduled maintenance, I don't anticipate trouble with this one either.
Overall a nice truck, until it gets a few miles. I bought two within 4 months. The first truck - no problems until 107K, then a high press oil pump and inter-cooler ($2,500, Ford offered to pay $500, but shop was 2-3 weeks backed up) and needs a front end ($1,500). Second truck - 130K miles then high press oil pump = another $1,500. Bought a '08 in April 2009, if the same problems occur, I will be finished with the F-250. Great truck, just trade before 100K.
This truck is awesome. It is everything Ford advertises it as and nothing more. Power from the v-10 is very comparable to my previous 460 big block. This is the best gasoline engine ever to come in a truck. The 6 speed manual works great and has probably the lightest smoothest clutch I have ever felt, while still handling the big power. The solid 1 ton axles can handle anything and the suspension rides firm and stable, just like a truck should. The gas mileage may only be 11-13 but that is the trade off you get with 355 horsepower and a heavy duty truck.