Overall my V6 SLE has been ok, but not what I expected from a Toyota. The parts are expensive ($200 for an O2 sensor, $250 for a pair of tires, $75 for a set of spark plugs), and the 18-20 MPG that it gets is now killing me at the pump ($60 won't fill the giant tank). The A/C controls are still a hassle to use, even after two years of owning the vehicle. The doors are extremely heavy (not good if you don't lift weights), and require plenty of room to open (not good if you live in a place with tight parking!). The exterior of the car is very attractive, and unfortunately it was that and the Toyota name that sold me this car. I wish I'd done some research!
I love the notepad/pen holder located in the dash and having a full sized spare is always a plus. Otherwise, the exterior is the best thing going for this car.
Fuel economy! After that, I would say they need to make the doors much shorter.