After years and years of research for the perfect "next" family car, my husband and I settled on a used (2008) RX 350, and couldn't be happier. We had bought a Chrysler Pacifica when they first came out in 2004 and had terrible luck with reliability, but couldn't justify trading it in until we got our money out of the thing. So basically we have been looking for the next car for 7 years. Having 2 younger children we were set on another three row vehicle, but were not happy with the costs of a new Pilot, Acadia, Highlander, etc. We then looked at the two row luxury market and almost got a Volvo xc70. I'm so glad we test drove the certified used RX 350 first. Love it!!! and the price.
I bought this car used with 60k miles on it, and 2.5 years later it's at 85k. In that time I've replaced a water pump (~$500) and a rack & pinion (~$1800). Everything else has been general maintenance (oil/brake/filter changes, etc.) The car handles well on the road, and I love the feel of driving it. It has enough engine to accelerate well and the suspension is setup to be comfortable, although it will feel a bit like turning a boat around sharp turns. Unfortunately, the interior of the car has some issues. The GPS is dated and clumsy to use. The controls for adjusting many common things like fan speed are buried inside a digital menu system that is difficult to use while driving if you want any more control than adjusting a temp and letting it decide whether to blow full speed or low speed fan to achieve that temp. There is no USB / aux input so you're stuck using a tape deck adapter or replacing the stereo console if you want to connect your phone. My biggest problem, however, has been that my dashboard cracked & melted (pics: http://imgur.com/a/B62He) This is part of known issue (https://www.carbuyingtips.com/articles/blog/lexus-to-pay-for-cracked-dashboard-repairs.htm) and is being replaced as part of a warranty recall.  Updating this review to reflect that Lexus did replace the dashboard after over a year of being on a waitlist to replace it.
We currently do not own a Lexus RX 350 but my husband and I did own a Lexus RX 300 up until someone driving 55 mph in a 30 mph zone hit us as we were sitting still at a stop light, the truck did not stop at all and hit us full force which consequently pushed us into a new Honda Pilot which was approximately five feet ahead of us. This accident totaled all three vehicles, but we were the only one who was able to drive our vehicle home, all though the impact knocked our lexus off it's frame, the truck's front end was practically gone. The insurance company totaled our vehicle, but it and God, saved both of our lives. I will and am looking forward to purchasing a Lexus RX 350 Asap.
I cannot begin to tell you how much we love this car. This is the 3rd Lexus in a row. First was a very fast/fun/reliable SC, (lasted to about 350,000 miles and still running) 2nd was an RX300 (not quite as reliable, but good enough I guess - traded at 194,000) This one though, is still better than both previous - only things added were trailer hitch, trailer lighting cord ("factory," just plugged it in to a provided and conveniently located chassis harness). "GADGETS" all seem to work wonderfully and its packed with gadgets. Wonderful comfortable ride.
I was looking for a mid-size SUV with power, luxury comfort, good handling, solid engineering, minimal maintenance and a quiet ride. I did a lot of research and test drove 7 different brands. The Lexus was clearly superior to all of the others. The RX350 checked all of the boxes and then some. It is as solid as a tank but it drives like a sport sedan. I knew I'd be sacrificing some MPG to get the power & responsiveness I wanted but I have been very pleased with the mileage considering I drive about 75% city and 25% highway. If I ever get tired of this car I know my next one will be a Lexus too. **Update: I have now owned this Lexus for more than a year and my original review still stands. I've had no maintenance issues and am still delighted with this vehicle.