Overall, great. Fuel economy is better than Highlander Hybrid I owned before. Getting over 29mpg overall, over 30 if I use pure gas. About 26-27 on Interstate. Apparently 87 octane is OK, no pinging. Mpg no different with high-test. Features were quite onerous at first but"I'm catching on". Most disappointing feature is , by far, GPS. Map base is outdated, voice recognition poor and some functions won't operate while moving. I realize you shouldn't be inputting while driving but sometimes you have a co-pilot. I have solved problem by mounting a Garmin on the dash. Marvelous ride!
I traded in my 2007 RX350 for this hybrid and have been quite pleased. It feels much more stable on the road. The navigation is disk based and is somewhat different, as it trades the touchscreen for a mouse-like control on the console. I miss the storage compartments in the back that are now taken by batteries. I expected higher MPG and would probably get it if driving stop-n-go on city streets, however Dallas driving uses lots of highways. It has good power, but I find myself starting slower, trying to reach the stated MPG. I initially used Premium fuel, then switched to Regular - noticed no difference in performance or MPG.
I have had my 2011 Rx 450h for over 2 years and love it. The gas mileage is decent. It is a comfortable ride and so far no problems. Bought it used in 2014. Just had to replace the battery which was bit costly around $240.