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2,287 listings
  • $27,163
    great price
    $5,800 below market
    • 43,952 miles
    • 2 accidents, 2 owners, corporate fleet vehicle
    • 22 City / 30 Hwy MPG
    • Carget Motors (451 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    Close

    Located in Woodbridge, VA / 451 miles away from Fort Wayne, IN

    The 2021 Mercedes-Benz E350 is a paragon of sophistication and performance in the luxury sedan segment. Powered by a turbocharged 2.0-liter four-cylin...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: No

    Personal Use Only: No

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    25 Combined MPG (22 City/30 Highway)

    Listing Information:

    VIN: W1KZF8EB7MA905081
    Stock: 905081
    Certified Pre-Owned: No
    Listed since: 12-13-2024

  • Price Drop
    $33,899
    great price
    $3,587 below market
    • 37,011 miles
    • No accidents, 1 owner, corporate fleet vehicle
    • 22 City / 30 Hwy MPG
    • Titan Auto Sales (143 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    Close

    Located in Worth, IL / 143 miles away from Fort Wayne, IN

    Step into the realm of luxury and performance with the 2021 Mercedes-Benz E-Class E 350 4MATIC! With a mere 37,011 miles on the odometer, this elegant...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: No

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    25 Combined MPG (22 City/30 Highway)

    Listing Information:

    VIN: W1KZF8EB3MA915980
    Stock: R6476
    Certified Pre-Owned: No

  • Price Drop
    $34,806
    great price
    $3,226 below market
    • 31,716 miles
    • No accidents, 2 owners, personal use
    • 22 City / 30 Hwy MPG
    • Burnsville Toyota (482 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    Close

    Located in Burnsville, MN / 482 miles away from Fort Wayne, IN

    *CLEAN CARFAX*, *CRUISE CONTROL*, *HEATED FRONT SEATS*, LEATHER SEATS*, BACKUP CAMERA*, MOONROOF*, ALLOY WHEELS*, BLUETOOTH*, E 350 4MATIC, 4MATIC. Cl...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    25 Combined MPG (22 City/30 Highway)

    Listing Information:

    VIN: W1KZF8EB4MA893049
    Stock: 1036353
    Certified Pre-Owned: No
    Listed since: 06-04-2025

  • $85,800
    good price
    $4,310 below market
    • 17,612 miles
    • 1 accident, 1 owner, personal use only
    • 16 City / 23 Hwy MPG
    • Mercedes-Benz of Annapolis (481 mi away)
    • AWD/4WD
    • Bluetooth
    • Navigation
    • Leather Seats
    • Sunroof/Moonroof
    Close

    Located in Annapolis, MD / 481 miles away from Fort Wayne, IN

    E 63 S AMG® 4MATIC®, 4.0L V8, Carfax 1 Owner, Acoustic Comfort Package, Active Brake Assist w/Cross-Traffic Function, Active Distance Assist DISTRONIC...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: No

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    18 Combined MPG (16 City/23 Highway)

    Listing Information:

    VIN: W1KZF8KB5MA982021
    Stock: QP982021
    Certified Pre-Owned: Yes
    Listed since: 03-13-2025

  • $46,880
    great price
    $1,147 below market
    • 53,276 miles
    • No accidents, 1 owner, personal use only
    • 6cyl automatic
    • Jack Schmitt Chevrolet of O'Fallon (304 mi away)
    • AWD/4WD
    • Bluetooth
    • Navigation
    • Leather Seats
    • Keyless Entry/Start
    Close

    Located in O Fallon, IL / 304 miles away from Fort Wayne, IN

    Clean CARFAX. CARFAX One-Owner. Priced below KBB Fair Purchase Price! This 2021 Mercedes-Benz E-Class comes equipped with the following - 4MATIC?, 13 ...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    25 Combined MPG (23 City/29 Highway)

    Listing Information:

    VIN: W1K1K5KB8MF164857
    Stock: 16341P
    Certified Pre-Owned: No
    Listed since: 05-30-2025

  • Price Drop
    $34,250
    fair price
    $889 below market
    • 52,804 miles
    • No accidents, 1 owner, personal use
    • 22 City / 30 Hwy MPG
    • Fishers Imports (88 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    Close

    Located in Fishers, IN / 88 miles away from Fort Wayne, IN

    Experience refined luxury with this 2021 Mercedes Benz E 350, featuring a sophisticated Surround View System, premium Burmester Surround Sound, expans...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    25 Combined MPG (22 City/30 Highway)

    Listing Information:

    VIN: W1KZF8EB6MA980919
    Stock: WI0919
    Certified Pre-Owned: No
    Listed since: 06-28-2025

  • $53,818
    fair price
    $1,736 below market
    • 9,459 miles
    • No accidents, 2 owners, personal use only
    • 6cyl automatic
    • Lindsay Volkswagen of Manassas (438 mi away)
    • Bluetooth
    • Navigation
    • Leather Seats
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Manassas, VA / 438 miles away from Fort Wayne, IN

    EXTERIOR LIGHTING PACKAGE!!, AMG LINE PACKAGE!!, VENTILATED SEATS!!, HEAD UP DISPLAY!!, ACTUAL MILES!!, E-Class E 450, 2D Convertible, 3.0L I6 Turbo, ...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    25 Combined MPG (23 City/30 Highway)

    Listing Information:

    VIN: W1K1K5JB5MF164087
    Stock: VP14799
    Certified Pre-Owned: No
    Listed since: 07-03-2025

  • Stock photo**
    $49,500
    good price
    $3,562 below market
    • 34,985 miles
    • No accidents, 1 owner, personal use
    • 22 City / 29 Hwy MPG
    • Lindsay Cadillac of Alexandria (456 mi away)
    • AWD/4WD
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    • Keyless Entry/Start
    Close

    Located in Alexandria, VA / 456 miles away from Fort Wayne, IN

    BUY ONLINE-TEXT-EMAIL-CHAT-PHONE AND WE WILL DELIVER YOUR NEXT VEHICLE TO YOUR DOOR! Priced below KBB Fair Purchase Price! 2021 Mercedes-Benz E-Class ...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    25 Combined MPG (22 City/29 Highway)

    Listing Information:

    VIN: W1KZF6BB2MA840410
    Stock: C17923A
    Certified Pre-Owned: No
    Listed since: 07-14-2025

  • Price Drop
    $36,997
    good price
    $2,242 below market
    • 24,052 miles
    • No accidents, 1 owner, personal use
    • 22 City / 30 Hwy MPG
    • Ourisman Lexus of Rockville (444 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    Close

    Located in Rockville, MD / 444 miles away from Fort Wayne, IN

    ONE OWNER, PREMIUM PKG, NAVIGATION, APPLE CAR PLAY/ANDROID AUTO, HEATED AND VENTILATED SEATS, MOONROOF, 18 ALLOY WHEELS, DYNAMIC RADAR CRUISE CONTROL,...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    25 Combined MPG (22 City/30 Highway)

    Listing Information:

    VIN: W1KZF8EB0MB000403
    Stock: TB000403
    Certified Pre-Owned: No
    Listed since: 07-07-2025

  • Price Drop
    $32,306
    good price
    $2,442 below market
    • 48,302 miles
    • No accidents, 2 owners, corporate fleet vehicle
    • 22 City / 30 Hwy MPG
    • Monroe Nissan (483 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    Close

    Located in Monroe, NC / 483 miles away from Fort Wayne, IN

    Black 2021 Mercedes-Benz E-Class E 350 4MATIC® 4MATIC® 9-Speed Automatic I4***THIS VEHICLE INCLUDES THE FOLLOWING FEATURES AND OPTIONS: Memory Packa...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: No

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    25 Combined MPG (22 City/30 Highway)

    Listing Information:

    VIN: W1KZF8EB2MA929255
    Stock: P3745
    Certified Pre-Owned: No
    Listed since: 07-17-2025

  • $36,995
    fair price
    $1,088 below market
    • 42,643 miles
    • No accidents, 1 owner, personal use only
    • 22 City / 30 Hwy MPG
    • Mercedes-Benz of St Charles (174 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    Close

    Located in Saint Charles, IL / 174 miles away from Fort Wayne, IN

    ** MERCEDES-BENZ CERTIFIED PRE-OWNED! **, ** PANORAMIC MOONROOF**, ** HEATED FRONT SEATS **, Active Parking Assist, Adaptive Highbeam Assist, AMG Line...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    25 Combined MPG (22 City/30 Highway)

    Listing Information:

    VIN: W1KZF8EB5MA909369
    Stock: P3349
    Certified Pre-Owned: Yes
    Listed since: 07-04-2025

  • Price Drop
    $38,730
    fair price
    $1,007 below market
    • 31,063 miles
    • No accidents, 1 owner, personal use
    • 22 City / 30 Hwy MPG
    • Mercedes-Benz of Lancaster (468 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    Close

    Located in East Petersburg, PA / 468 miles away from Fort Wayne, IN

    Priced below KBB Fair Purchase Price! CARFAX One-Owner. Odometer is 5978 miles below market average! 22/30 City/Highway MPG Clean CARFAX. Certified. L...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    25 Combined MPG (22 City/30 Highway)

    Listing Information:

    VIN: W1KZF8EB5MA968468
    Stock: MB12170A
    Certified Pre-Owned: Yes
    Listed since: 06-11-2025

  • $57,995
    great price
    $6,111 below market
    • 82,254 miles
    • No accidents, 1 owner, personal use only
    • 16 City / 23 Hwy MPG
    • TLEE Auto Brokers (493 mi away)
    • AWD/4WD
    • Bluetooth
    • Navigation
    • Leather Seats
    • Sunroof/Moonroof
    Close

    Located in Duluth, GA / 493 miles away from Fort Wayne, IN

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    18 Combined MPG (16 City/23 Highway)

    Listing Information:

    VIN: W1KZF8KB1MA931678
    Stock: 931678
    Certified Pre-Owned: No

  • $25,222
    good price
    $839 below market
    • 83,494 miles
    • No accidents, 1 owner, personal use
    • 22 City / 30 Hwy MPG
    • Carget Motors (451 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    Close

    Located in Woodbridge, VA / 451 miles away from Fort Wayne, IN

    The 2021 Mercedes-Benz E 350 exemplifies modern luxury and intelligent design, offering a driving experience that s both refined and engaging. Powered...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    25 Combined MPG (22 City/30 Highway)

    Listing Information:

    VIN: W1KZF8EB8MA966973
    Stock: 966973
    Certified Pre-Owned: No
    Listed since: 07-11-2025

  • Price Drop
    $31,889
    fair price
    $616 below market
    • 43,624 miles
    • 1 accident, 2 owners, corporate fleet vehicle
    • 22 City / 31 Hwy MPG
    • Southeast Auto Direct (464 mi away)
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    • Keyless Entry/Start
    Close

    Located in Iuka, MS / 464 miles away from Fort Wayne, IN

    THE LOWEST PRICED IN 150 MILES!! BACKUP CAMERA, BLUETOOTH, NAVIGATION SYSTEM GPS NAV, SUNROOF/MOONROOF, GOOGLE ANDROID AUTO, APPLE CARPLAY, POWER PAC...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: No

    Personal Use Only: No

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    25 Combined MPG (22 City/31 Highway)

    Listing Information:

    VIN: W1KZF8DBXMA887130
    Stock: 7K2736PA
    Certified Pre-Owned: No
    Listed since: 06-19-2025

  • Price Drop
    $31,029
    good price
    $1,637 below market
    • 47,623 miles
    • No accidents, 2 owners, personal use
    • 22 City / 30 Hwy MPG
    • Mercedes-Benz of St Louis (320 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    Close

    Located in Saint Louis, MO / 320 miles away from Fort Wayne, IN

    Black 2021 Mercedes-Benz E-Class E 350 4MATIC® E 350 4MATIC® 4MATIC® 9-Speed Automatic I4 This Vehicle Includes the Following Features:, 4MATIC®, Acti...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    25 Combined MPG (22 City/30 Highway)

    Listing Information:

    VIN: W1KZF8EB8MA881387
    Stock: PC807A
    Certified Pre-Owned: No
    Listed since: 05-30-2025

  • $59,793
    fair price
    $260 below market
    • 5,449 miles
    • No accidents, 1 owner, personal use only
    • 22 City / 29 Hwy MPG
    • Mercedes-Benz of North Olmsted (169 mi away)
    • AWD/4WD
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    • Keyless Entry/Start
    Close

    Located in North Olmsted, OH / 169 miles away from Fort Wayne, IN

    BACK-UP CAMERA, BLUETOOTH HANDS FREE PHONE, HEATED AND COOLED SEATS, LEATHER, MOONROOF, NAVIGATION, NO ACCIDENTS, ULTRA LOW MILES, WORRY FREE PRICING....

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    25 Combined MPG (22 City/29 Highway)

    Listing Information:

    VIN: W1KZF6BB7MA993137
    Stock: M8970
    Certified Pre-Owned: No
    Listed since: 07-22-2025

  • New Listing
    • 9,073 miles
    • No accidents, 2 owners, personal use
    • 7 Seats, 22 City / 28 Hwy MPG
    • Carvana - Columbus (136 mi away)
    • Home delivery*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    Close

    Located in Columbus, OH / 136 miles away from Fort Wayne, IN

    At Carvana, we go miles beyond the extra mile. That's why we provide you with a convenient, fast, and hassle-free car buying experience that puts you ...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    24 Combined MPG (22 City/28 Highway)

    Listing Information:

    VIN: W1KZH6ABXMA975498
    Stock: 2003931161
    Certified Pre-Owned: No
    Listed since: 07-31-2025

  • Price Drop
    $36,990
    fair price
    $24 below market
    • 35,345 miles
    • No accidents, 3 owners, personal use
    • 22 City / 30 Hwy MPG
    • Carvana - Indianapolis (104 mi away)
    • Home delivery*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    Close

    Located in Indianapolis, IN / 104 miles away from Fort Wayne, IN

    At Carvana, we go miles beyond the extra mile. That's why we provide you with a convenient, fast, and hassle-free car buying experience that puts you ...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    25 Combined MPG (22 City/30 Highway)

    Listing Information:

    VIN: W1KZF8EB2MA924797
    Stock: 2003773722
    Certified Pre-Owned: No
    Listed since: 06-03-2025

  • $35,000
    fair price
    $902 below market
    • 25,158 miles
    • 1 accident, 2 owners, personal use
    • 22 City / 30 Hwy MPG
    • Porsche Downtown Chicago (140 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    Close

    Located in Chicago, IL / 140 miles away from Fort Wayne, IN

    2021 Mercedes-Benz E-Class E 350 4MATIC® E 350 Polar White I4 Porsche Downtown Chicago, under the leadership of our new General Manager, Stuart Nelson...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: No

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    25 Combined MPG (22 City/30 Highway)

    Listing Information:

    VIN: W1KZF8EB8MA970313
    Stock: PSN1055A
    Certified Pre-Owned: No
    Listed since: 05-23-2025

  • $39,897
    fair price
    $1,052 above market
    • 14,310 miles
    • No accidents, 1 owner, personal use
    • 22 City / 30 Hwy MPG
    • Mercedes-Benz of Alexandria (454 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    Close

    Located in Alexandria, VA / 454 miles away from Fort Wayne, IN

    CARFAX One-Owner. Clean CARFAX. Recent Arrival! Certified. 2021 Mercedes-Benz E-Class E 350 4MATIC® 4MATIC®.Mercedes-Benz Certified Pre-Owned Detail...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    25 Combined MPG (22 City/30 Highway)

    Listing Information:

    VIN: W1KZF8EB2MA954432
    Stock: P954432A
    Certified Pre-Owned: Yes
    Listed since: 06-03-2025

Showing 1 - 21 out of 2,287 listings

Consumer Reviews for the Mercedes-Benz E-Class

Read recent reviews for the Mercedes-Benz E-Class
Overall Consumer Rating
4.5 out of 5 stars33 Reviews
Write a vehicle reviewSee all 33 reviews
  • 5 star
    (73%)
  • 4 star
    (21%)
  • 3 star
    (0%)
  • 2 star
    (0%)
  • 1 star
    (6%)
5 out of 5 stars

New 2021 E-Class with MBUX is a Great Car

gldman, 12/14/2020
2021 Mercedes-Benz E-Class E 350 4dr Sedan (2.0L 4cyl Turbo 9A)
I drove the competitors BMW 5, Audi 6, Lexus ES 350 and this new E Class is really something special. I had the other cars via a Subscription Model including the 2020 Mercedes so I have recent experience for weeks at a time driving the cars. The MBUX is a great user experience. Buy the Premium package because of the 360 camera and the upgraded audio system. The other add-on stuff is … fun but not really needed. You will use Android Auto and not the Mercedes Navi if you want accurate directions. The Mercedes Navi is very pretty but useless for directions. The Augmented Reality is fun, once, and may impress your friends but is more of a distraction than a help. The Driver Assistance package is interesting but the distronic cruise control is the only thing you will actually use from this package. This is a truly comfortable car with the latest electronics. Note if you never have had a Mercedes you will need a good independent mechanic to do your A/B Services (Oil Changes) if you want to avoid the the dealer. You must log all service in the electronic service log which all of the good independent shops will do. Note the Lexus is the best value if not boring, with regular gas and standard oil changes, but I think with the 2021 updates the Mercedes E 350 is more fun than the Audi 6 (watch for recalls) or BMW 5 (needs updating to stay competitive). Obviously you should compare similar versions of each model. Update 2 years later: Well the car is still great. I only have 7,350 miles and just dropped the car for a B Service. So far no problems except for a few early glitches with the cameras that resolved after a restart, Note the dealer costs for A & especially B Service is nuts. I was quoted $1,529.74 for a B Service at the dealer. I am trying a local specialty place that charges $450. I guess I will see. Last year another specialty shop charged $250 for an A service which was fine compared to $595 at the dealer.
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Used 2021 Mercedes-Benz E-Class in Fort Wayne, IN Values

Estimated values
2021 Mercedes-Benz E-Class E 350 4MATIC 4dr Sedan AWD (2.0L 4cyl Turbo 9A) with no options
ConditionTrade-InPrivate PartyDealer Retail
Outstanding$28,447$31,566$34,715
Clean$27,844$30,842$33,858
Average$26,840$29,635$32,430
Rough$25,534$28,066$30,574

The average list price of a used 2021 Mercedes-Benz E-Class in Fort Wayne, Indiana is $42,121. The average mileage on a used Mercedes-Benz E-Class 2021 for sale in Fort Wayne, Indiana is 36,819. Based on the average mileage of 36,819 for used 2021 Mercedes-Benz E-Class for sale in Fort Wayne, IN and using an average vehicle condition rating, which means the vehicle may have a few mechanical and/or cosmetic problems and may require a considerable amount of reconditioning, we appraise the average trade-in value of a used Mercedes-Benz E-Class 2021 in Fort Wayne, Indiana to be $26,840.

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* Delivery of any kind does not apply to Alaska and Hawaii. Contact the dealer for delivery details, restrictions and costs.