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3,181 listings
  • Price Drop
    • 31,560 miles
    • No accidents, 1 owner, personal use
    • 7 Seats, 22 City / 28 Hwy MPG
    • Carvana - Atlanta (349 mi away)
    • Home delivery*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    Close

    Located in Atlanta, GA / 349 miles away from Roanoke, VA

    At Carvana, we go miles beyond the extra mile. That's why we provide you with a convenient, fast, and hassle-free car buying experience that puts you ...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    24 Combined MPG (22 City/28 Highway)

    Listing Information:

    VIN: W1KZH6AB6MA987258
    Stock: 2003696682
    Certified Pre-Owned: No
    Listed since: 05-16-2025

  • Price Drop
    $41,996
    fair price
    $957 below market
    • 27,253 miles
    • No accidents, 2 owners, personal use
    • 23 City / 30 Hwy MPG
    • Ronnie Watkins Ford (408 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    Close

    Located in Gadsden, AL / 408 miles away from Roanoke, VA

    Only 27,219 Miles! Boasts 30 Highway MPG and 23 City MPG! This Mercedes-Benz E-Class boasts a Intercooled Turbo Gas/Electric I-6 3.0 L/183 engine pow...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    26 Combined MPG (23 City/30 Highway)

    Listing Information:

    VIN: W1KZF5KB6MA876479
    Stock: MA876479
    Certified Pre-Owned: No
    Listed since: 03-17-2025

  • $29,499
    good price
    $1,562 below market
    • 57,444 miles
    • No accidents, 1 owner, corporate fleet vehicle
    • 22 City / 30 Hwy MPG
    • Queens Auto Mall (405 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    Close

    Located in Queens, NY / 405 miles away from Roanoke, VA

    2021 Mercedes-Benz E-Class E 350 4MATIC 9-Speed Automatic I4 22/30 City/Highway MPG Oil Change Performed, 120 point inspection Performed, CLEAN CARFAX...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: No

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    25 Combined MPG (22 City/30 Highway)

    Listing Information:

    VIN: W1KZF8EB2MA962885
    Stock: 084345
    Certified Pre-Owned: No
    Listed since: 03-12-2024

  • $30,095
    good price
    $2,113 below market
    • 50,184 miles
    • No accidents, 1 owner, personal use
    • 22 City / 30 Hwy MPG
    • Lynnes Nissan City (393 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    Close

    Located in Bloomfield, NJ / 393 miles away from Roanoke, VA

    This 2021 Mercedes-Benz E-Class has passed the Lynnes comprehensive 172 point inspection with flying colors. Our ASE certified technicians have inspec...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    25 Combined MPG (22 City/30 Highway)

    Listing Information:

    VIN: W1KZF8EB0MA975425
    Stock: E8373P
    Certified Pre-Owned: No
    Listed since: 05-20-2025

  • New Listing
    $38,000
    good price
    $2,788 below market
    • 48,179 miles
    • 1 accident, 2 owners, personal use
    • 6cyl automatic
    • Mercedes-Benz Of Massapequa (423 mi away)
    • AWD/4WD
    • Bluetooth
    • Navigation
    • Leather Seats
    • Sunroof/Moonroof
    Close

    Located in Amityville, NY / 423 miles away from Roanoke, VA

    Certified.2021 Mercedes-Benz E-Class E 450 4MATIC�® 3.0L I6 Turbo 4MATIC�® 9-Speed Automatic Black4MATIC�®, Active Distance Assist DISTRON...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: No

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    25 Combined MPG (23 City/30 Highway)

    Listing Information:

    VIN: W1K1J5KB6MF149678
    Stock: MF149678T
    Certified Pre-Owned: Yes
    Listed since: 04-08-2025

  • Price Drop
    $44,644
    good price
    $2,392 below market
    • 33,232 miles
    • 1 accident, 2 owners, personal use
    • 6cyl automatic
    • Nissan of Hampton (196 mi away)
    • Bluetooth
    • Navigation
    • Leather Seats
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Hampton, VA / 196 miles away from Roanoke, VA

    SummaryWelcome to Nissan of Hampton. Our team strives to make your next vehicle purchase hassle free.Vehicle DetailsExperience the t...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: No

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    25 Combined MPG (23 City/30 Highway)

    Listing Information:

    VIN: W1K1K5JBXMF159614
    Stock: UP159614
    Certified Pre-Owned: No
    Listed since: 04-08-2025

  • Price Drop
    $36,500
    good price
    $1,823 below market
    • 24,643 miles
    • 1 accident, 1 owner, personal use
    • 22 City / 30 Hwy MPG
    • Fishers Imports (376 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    Close

    Located in Fishers, IN / 376 miles away from Roanoke, VA

    Check out this stunning Mercedes E 350, loaded with premium features to elevate your driving experience. It comes with the Premium Package, which incl...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: No

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    25 Combined MPG (22 City/30 Highway)

    Listing Information:

    VIN: W1KZF8EBXMA970944
    Stock: I0944
    Certified Pre-Owned: No
    Listed since: 05-16-2025

  • Price Drop
    • 17,612 miles
    • 1 accident, 1 owner, personal use only
    • 16 City / 23 Hwy MPG
    • Mercedes-Benz of Annapolis (222 mi away)
    • AWD/4WD
    • Bluetooth
    • Navigation
    • Leather Seats
    • Sunroof/Moonroof
    Close

    Located in Annapolis, MD / 222 miles away from Roanoke, VA

    E 63 S AMG® 4MATIC®, 4.0L V8, Carfax 1 Owner, Acoustic Comfort Package, Active Brake Assist w/Cross-Traffic Function, Active Distance Assist DISTRONIC...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: No

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    18 Combined MPG (16 City/23 Highway)

    Listing Information:

    VIN: W1KZF8KB5MA982021
    Stock: QP982021
    Certified Pre-Owned: Yes
    Listed since: 03-13-2025

  • $38,714
    fair price
    $431 above market
    • 15,555 miles
    • No accidents, 2 owners, personal use only
    • 22 City / 30 Hwy MPG
    • Jim McKay Chevrolet (181 mi away)
    • Five Star Dealer
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    Close

    Located in Fairfax, VA / 181 miles away from Roanoke, VA

    Odometer is 25619 miles below market average! 2021 Mercedes-Benz E-Class E 350 Brilliant Blue Metallic 4MATIC® 9-Speed Automatic I4Recent Arrival! 2...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    25 Combined MPG (22 City/30 Highway)

    Listing Information:

    VIN: W1KZF8EB8MA935710
    Stock: CP1444
    Certified Pre-Owned: No
    Listed since: 05-16-2025

  • New Listing
    $31,750
    good price
    $1,976 below market
    • 44,167 miles
    • 1 accident, 1 owner, corporate fleet vehicle
    • 22 City / 30 Hwy MPG
    • Luxury Motor Club (412 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    Close

    Located in Franklin Square, NY / 412 miles away from Roanoke, VA

    * MSRP 65,715 * PREMIUM PKG * DRIVER ASSISTANCE PKG * BLIND SPOT ASSIST * LANE KEEPING ASSIST * BRAKE ASSIST * SMART DEVICE REMOTE ENGINE START * PANO...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: No

    Personal Use Only: No

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    25 Combined MPG (22 City/30 Highway)

    Listing Information:

    VIN: W1KZF8EB5MA947927
    Stock: 947927
    Certified Pre-Owned: No
    Listed since: 05-05-2025

  • Price Drop
    $33,488
    fair price
    $312 above market
    • 36,734 miles
    • No accidents, 1 owner, personal use
    • 22 City / 31 Hwy MPG
    • Johnson Lexus of Durham (109 mi away)
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    • Keyless Entry/Start
    Close

    Located in Durham, NC / 109 miles away from Roanoke, VA

    PRICED AT THOUSANDS BELOW RETAIL VALUE OF $41,038 FOR A QUICK AND HASSLE-FREE SALE! RECENT TRADE-IN! ONLY 36,734 MILES! BRAND NEW TIRES! PERFECTLY MAI...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    25 Combined MPG (22 City/31 Highway)

    Listing Information:

    VIN: W1KZF8DB6MA995065
    Stock: D25596A
    Certified Pre-Owned: No
    Listed since: 04-01-2025

  • $29,497
    good price
    $1,439 below market
    • 57,906 miles
    • 1 accident, 1 owner, corporate fleet vehicle
    • 22 City / 30 Hwy MPG
    • Magnetism Motors (327 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    Close

    Located in Lawrenceville, GA / 327 miles away from Roanoke, VA

    This 2021 Mercedes-Benz E-Class 4dr E 350 4MATIC Sedan features a 2.0L 4 CYLINDER 4cyl Gasoline engine. It is equipped with a 9 Speed Automatic transm...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: No

    Personal Use Only: No

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    25 Combined MPG (22 City/30 Highway)

    Listing Information:

    VIN: W1KZF8EB8MA923637
    Stock: MA923637
    Certified Pre-Owned: No
    Listed since: 02-25-2025

  • Price Drop
    $97,990
    fair price
    $2,426 above market
    • 12,190 miles
    • No accidents, 1 owner, personal use only
    • 16 City / 23 Hwy MPG
    • Kia Of Riverdale (396 mi away)
    • AWD/4WD
    • Bluetooth
    • Navigation
    • Leather Seats
    • Sunroof/Moonroof
    Close

    Located in Riverdale, NJ / 396 miles away from Roanoke, VA

    designo Selenite Gray Magno 2021 Mercedes-Benz E-Class E 63 S AMG® 4MATIC® 4MATIC® 4MATIC® 9-Speed Automatic 4.0L V8 4MATIC®.Recent Arrival!Award...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    18 Combined MPG (16 City/23 Highway)

    Listing Information:

    VIN: W1KZF8KB6MB004153
    Stock: 004153C01
    Certified Pre-Owned: No
    Listed since: 05-16-2025

  • New Listing
    • 33,132 miles
    • No accidents, 2 owners, personal use
    • 6cyl automatic
    • Mercedes-Benz Of Massapequa (423 mi away)
    • AWD/4WD
    • Bluetooth
    • Navigation
    • Leather Seats
    • Keyless Entry/Start
    Close

    Located in Amityville, NY / 423 miles away from Roanoke, VA

    Certified. Clean CARFAX.2021 Mercedes-Benz E-Class E 450 4MATIC® 3.0L I6 Turbo 4MATIC® 9-Speed Automatic designo Diamond White4MATIC®, 19"...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    25 Combined MPG (23 City/29 Highway)

    Listing Information:

    VIN: W1K1K5KB4MF149708
    Stock: MF149708T
    Certified Pre-Owned: Yes
    Listed since: 05-13-2025

  • Price Drop
    • 19,259 miles
    • Insurance loss reported, 1 owner, personal use
    • 22 City / 31 Hwy MPG
    • ALM Kia South (363 mi away)
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    • Keyless Entry/Start
    Close

    Located in Union City, GA / 363 miles away from Roanoke, VA

    SUNROOF/MOONROOF..MEMORY SEATS..LANE DEPARTURE WARNING..HEATED SEATS..BLIND SPOT MONITOR..HANDS-FREE LIFTGATE..COLLISION WARNING..AUTOMATIC CLIMATE CO...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Issue reported

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: Yes

    Free History Report: No

    Features and Specs:

    25 Combined MPG (22 City/31 Highway)

    Listing Information:

    VIN: W1KZF8DBXMA895387
    Stock: MA895387
    Certified Pre-Owned: No
    Listed since: 12-27-2024

  • Price Drop
    $38,899
    fair price
    $1,493 above market
    • 38,991 miles
    • No accidents, 1 owner, personal use
    • 22 City / 30 Hwy MPG
    • i.g. Burton & Co. (271 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    Close

    Located in Milford, DE / 271 miles away from Roanoke, VA

    **SOLD NEW HERE, **HAND PICKED OFF LEASE, **EXTRA CLEAN, **CLEAN CARFAX, SERVICED WITH US, EXTRA LOW MILES, HEAT SEATS, MOONROOF, NEW TIRES !, NO ACCI...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    25 Combined MPG (22 City/30 Highway)

    Listing Information:

    VIN: W1KZF8EB8MB005798
    Stock: 625010
    Certified Pre-Owned: Yes
    Listed since: 02-24-2025

  • $88,800
    fair price
    $409 above market
    • 29,936 miles
    • No accidents, 1 owner, personal use only
    • 16 City / 23 Hwy MPG
    • Space Auto Group (371 mi away)
    • AWD/4WD
    • Bluetooth
    • Navigation
    • Leather Seats
    • Sunroof/Moonroof
    Close

    Located in East Brunswick, NJ / 371 miles away from Roanoke, VA

    Real Prices, No Surprises! At Space Auto Group, we stand out among other dealerships by offering a transparent and honest car-buying process. No hidde...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    18 Combined MPG (16 City/23 Highway)

    Listing Information:

    VIN: W1KZF8KB3MA958073
    Stock: S10286X
    Certified Pre-Owned: No

  • $39,190
    fair price
    $927 below market
    • 39,775 miles
    • 1 accident, 2 owners, personal use
    • 6cyl automatic
    • Gravity Autos Jacksonville (488 mi away)
    • AWD/4WD
    • Bluetooth
    • Navigation
    • Leather Seats
    • Sunroof/Moonroof
    Close

    Located in Jacksonville, FL / 488 miles away from Roanoke, VA

    $6K+ IN OPTIONS! AMG LINE PACKAGE, NIGHT PACKAGE, EXTERIOR LIGHTING PACKAGE, VENTILATED FRONT SEATS, 19'' AMG TWIN 5-SPOKE WHEELS W/BLACK ACCENT, WHEE...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: No

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    25 Combined MPG (23 City/30 Highway)

    Listing Information:

    VIN: W1K1J5KB9MF166703
    Stock: 166703
    Certified Pre-Owned: No
    Listed since: 02-28-2025

  • Price Drop
    $36,987
    fair price
    $307 above market
    • 17,000 miles
    • 1 accident, 1 owner, personal use
    • 22 City / 30 Hwy MPG
    • CarPalace (176 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    Close

    Located in Chantilly, VA / 176 miles away from Roanoke, VA

    Discover Your Dream Car at CARPALACE – Quality Used Cars, Unbeatable Prices!At CARPALACE, we're passionate about helping you find the perfect ve...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: No

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    25 Combined MPG (22 City/30 Highway)

    Listing Information:

    VIN: W1KZF8EB5MA964419
    Stock: 2025189
    Certified Pre-Owned: No

    • 68,653 miles
    • No accidents, 1 owner, personal use only
    • 7 Seats, 22 City / 28 Hwy MPG
    • Land Rover Huntington (430 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    Close

    Located in Huntington, NY / 430 miles away from Roanoke, VA

    2021 Mercedes-Benz E-Class Cirrus Silver Metallic Active Distance Assist DISTRONIC�, Active Lane Change Assist, Active Speed Limit Assist, Active Stee...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    24 Combined MPG (22 City/28 Highway)

    Listing Information:

    VIN: W1KZH6AB2MA924450
    Stock: 5595S
    Certified Pre-Owned: No
    Listed since: 04-23-2025

  • Price Drop
    • 14,932 miles
    • No accidents, 1 owner, personal use
    • 22 City / 30 Hwy MPG
    • Mercedes-Benz of Edison (374 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    Close

    Located in Edison, NJ / 374 miles away from Roanoke, VA

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    25 Combined MPG (22 City/30 Highway)

    Listing Information:

    VIN: W1KZF8EB5MA916189
    Stock: P04008
    Certified Pre-Owned: Yes
    Listed since: 04-11-2025

Showing 22 - 42 out of 3,181 listings

Consumer Reviews for the Mercedes-Benz E-Class

Read recent reviews for the Mercedes-Benz E-Class
Overall Consumer Rating
4.5 out of 5 stars33 Reviews
Write a vehicle reviewSee all 33 reviews
  • 5 star
    (73%)
  • 4 star
    (21%)
  • 3 star
    (0%)
  • 2 star
    (0%)
  • 1 star
    (6%)
5 out of 5 stars

New 2021 E-Class with MBUX is a Great Car

gldman, 12/14/2020
2021 Mercedes-Benz E-Class E 350 4dr Sedan (2.0L 4cyl Turbo 9A)
I drove the competitors BMW 5, Audi 6, Lexus ES 350 and this new E Class is really something special. I had the other cars via a Subscription Model including the 2020 Mercedes so I have recent experience for weeks at a time driving the cars. The MBUX is a great user experience. Buy the Premium package because of the 360 camera and the upgraded audio system. The other add-on stuff is … fun but not really needed. You will use Android Auto and not the Mercedes Navi if you want accurate directions. The Mercedes Navi is very pretty but useless for directions. The Augmented Reality is fun, once, and may impress your friends but is more of a distraction than a help. The Driver Assistance package is interesting but the distronic cruise control is the only thing you will actually use from this package. This is a truly comfortable car with the latest electronics. Note if you never have had a Mercedes you will need a good independent mechanic to do your A/B Services (Oil Changes) if you want to avoid the the dealer. You must log all service in the electronic service log which all of the good independent shops will do. Note the Lexus is the best value if not boring, with regular gas and standard oil changes, but I think with the 2021 updates the Mercedes E 350 is more fun than the Audi 6 (watch for recalls) or BMW 5 (needs updating to stay competitive). Obviously you should compare similar versions of each model. Update 2 years later: Well the car is still great. I only have 7,350 miles and just dropped the car for a B Service. So far no problems except for a few early glitches with the cameras that resolved after a restart, Note the dealer costs for A & especially B Service is nuts. I was quoted $1,529.74 for a B Service at the dealer. I am trying a local specialty place that charges $450. I guess I will see. Last year another specialty shop charged $250 for an A service which was fine compared to $595 at the dealer.
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Used 2021 Mercedes-Benz E-Class in Roanoke, VA Values

Estimated values
2021 Mercedes-Benz E-Class E 450 4MATIC All-Terrain 4dr Wagon AWD (3.0L 6cyl Turbo gas/electric mild hybrid 9A) with no options
ConditionTrade-InPrivate PartyDealer Retail
Outstanding$38,941$43,575$48,252
Clean$38,116$42,575$47,062
Average$36,740$40,909$45,077
Rough$34,953$38,743$42,497

The average list price of a used 2021 Mercedes-Benz E-Class in Roanoke, Virginia is $46,289. The average mileage on a used Mercedes-Benz E-Class 2021 for sale in Roanoke, Virginia is 34,207. Based on the average mileage of 34,207 for used 2021 Mercedes-Benz E-Class for sale in Roanoke, VA and using an average vehicle condition rating, which means the vehicle may have a few mechanical and/or cosmetic problems and may require a considerable amount of reconditioning, we appraise the average trade-in value of a used Mercedes-Benz E-Class 2021 in Roanoke, Virginia to be $36,740.

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* Delivery of any kind does not apply to Alaska and Hawaii. Contact the dealer for delivery details, restrictions and costs.