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267 listings
  • Price Drop
    $41,472
    fair price
    $1,478 below market
    • 33,789 miles
    • No accidents, 1 owner, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Driveway (In-stock online)
    • Home delivery*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Sunroof/Moonroof
    • Keyless Entry/Start
    Close

    Located in Bloomfield, NJ / 2,388 miles away from Reno, NV

    CarFax 1-Owner,Green Vehicle,Apple CarPlay,Back-Up Camera,Blind Spot Monitor,Bluetooth,Brake Assist,Heated Seats,Heated Steering Wheel,Keyless Start,L...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA4NC084311
    Stock: BBP10008
    Certified Pre-Owned: No

  • $31,677
    fair price
    $1,119 below market
    • 53,544 miles
    • 2 accidents, 2 owners, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Mossy Nissan Oceanside (458 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Oceanside, CA / 458 miles away from Reno, NV

    MOSSY NISSAN OCEANSIDE HUGE SELECTION OF PRE-OWNED VEHICLES CALL FOR AVAILABILITY (760) 720-9797. RX 450h, 4D Sport Utility, 3.5L V6 DOHC VVT-i 24V, e...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: No

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2BGMCA3JC025607
    Stock: 825643
    Certified Pre-Owned: No
    Listed since: 06-23-2025

  • New Listing
    • 33,850 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Carvana (In-stock online)
    • Home delivery*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Dallas, TX / 1,366 miles away from Reno, NV

    At Carvana, we go miles beyond the extra mile. That's why we provide you with a convenient, fast, and hassle-free car buying experience that puts you ...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA1LC055801
    Stock: 2003929900
    Certified Pre-Owned: No
    Listed since: 07-26-2025

  • New Listing
    $33,999
    fair price
    $423 above market
    • 57,007 miles
    • No accidents, 4 owners, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Escondido Auto Super Center (466 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Escondido, CA / 466 miles away from Reno, NV

    White 30 Day - 1000 Mile Comprehensive Warranty. Odometer is 11588 miles below market average! 31/28 City/Highway MPGNO HAGGLE PRICING! OUR INVENTORY ...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2BGMCA5JC024412
    Stock: 26771
    Certified Pre-Owned: No
    Listed since: 07-02-2025

  • $34,995
    fair price
    $227 above market
    • 85,026 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Freeman Motor Company (437 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Portland, OR / 437 miles away from Reno, NV

    Freeman Motor Company is a 3 time winner of Oregon's QUALITY Dealer of the YEAR. You can connect with us by calling 5**-3**-5***.Call now or visit our...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA7LC055253
    Stock: 055253
    Certified Pre-Owned: No
    Listed since: 04-26-2025

  • $33,995
    good price
    $990 below market
    • 101,197 miles
    • 1 accident, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Clear Choice Automotive (432 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Milwauikie, OR / 432 miles away from Reno, NV

    1 OWNER, VERY CLEAN, FULLY LOADED, CLEAN TITLE, APPLY ONLINE, LOOKS AND DRIVES GREAT.... DON'T MISS OUT........ CLEARCHOICEAUTOMOTIVE.COM _____APPLY O...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: No

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA8NC094131
    Stock: 094131
    Certified Pre-Owned: No
    Listed since: 04-17-2025

  • $36,995
    good price
    $1,311 below market
    • 48,956 miles
    • 1 accident, 1 owner, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Driveway (In-stock online)
    • Home delivery*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    Close

    Located in Ramsey, NJ / 2,387 miles away from Reno, NV

    CarFax 1-Owner,Rare Find,Green Vehicle,Apple CarPlay,Back-Up Camera,Blind Spot Monitor,Bluetooth,Brake Assist,Heated Seats,Heated Steering Wheel,Keyle...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: No

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA0LC047351
    Stock: SS675883A
    Certified Pre-Owned: No

  • Price Drop
    $25,900
    fair price
    $214 above market
    • 96,361 miles
    • 2 accidents, 2 owners, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Norm Reeves Genesis of Cerritos (400 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Cerritos, CA / 400 miles away from Reno, NV

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: No

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2BGMCA4JC027768
    Stock: JC027768G
    Certified Pre-Owned: No
    Listed since: 07-09-2025

    • 16,924 miles
    • No accidents, 1 owner, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • CarMax (In-stock online)
    • Transfer available from FL to NV*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Jacksonville, FL / 2,238 miles away from Reno, NV

    CarMax values transparency and wants you to love your next car, not settle on it. Certain vehicles may have unrepaired safety recalls. Check nhtsa.gov...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: Yes

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA7NC084481
    Stock: 27496594
    Certified Pre-Owned: No

  • $43,488
    fair price
    $39 below market
    • 52,498 miles
    • 1 accident, 2 owners, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Axio Automotive Boise (341 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    Close

    Located in Boise, ID / 341 miles away from Reno, NV

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: No

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA7NC073934
    Stock: 073934
    Certified Pre-Owned: No
    Listed since: 06-29-2025

  • $45,995
    fair price
    $1,594 above market
    • 51,656 miles
    • 1 accident, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Lexus of Santa Barbara (349 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Keyless Entry/Start
    Close

    Located in Santa Barbara, CA / 349 miles away from Reno, NV

    **SPRING INTO SAVINGS SALES EVENT GOING ON NOW!**2022 Lexus RX 450h F Sport Ultra White 3.5L V6 DOHC VVT-i 24V eCVT AWD3.5L V6 DOHC VVT-i 24V, AWD, Ci...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: No

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2YGMDA0NC079266
    Stock: L17231P
    Certified Pre-Owned: No
    Listed since: 01-18-2025

  • New Listing
    • 26,041 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Carvana (In-stock online)
    • Home delivery*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Richmond, VA / 2,266 miles away from Reno, NV

    At Carvana, we go miles beyond the extra mile. That's why we provide you with a convenient, fast, and hassle-free car buying experience that puts you ...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA8NC077183
    Stock: 2003886218
    Certified Pre-Owned: No
    Listed since: 07-23-2025

  • Price Drop
    • 32,982 miles
    • No accidents, 1 owner, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Lexus of Woodland Hills (374 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Sunroof/Moonroof
    • Keyless Entry/Start
    Close

    Located in Woodland Hills, CA / 374 miles away from Reno, NV

    450h ONE OWNER, HEATED & VENTILATED SEATS, POWER TILT-AND-SLIDE MOONROOF, BLIND SPOT MONITOR, INTUITIVE PARKING, ILLUMINATED DOOR SILLS, HEATED LEATHE...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA7NC087123
    Stock: B4194
    Certified Pre-Owned: No
    Listed since: 07-14-2025

  • New Listing
    • 37,041 miles
    • No accidents, 1 owner, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Ron Tonkin Chevrolet (439 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Portland, OR / 439 miles away from Reno, NV

    Just Arrived!!!! Premium Pkg, Moonroof, Cold Weather Pkg, Heated/Ventilated Seats!!! Priced Below Market!!!!Recent Arrival! 2022 Lexus RX 3.5L V6 DOHC...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA5NC076587
    Stock: PCT0201
    Certified Pre-Owned: No
    Listed since: 03-17-2025

  • New Listing
    • 34,670 miles
    • No accidents, 2 owners, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Acura of Salem (409 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Salem, OR / 409 miles away from Reno, NV

    Nebula Gray Pearl 2022 Lexus RX 450h F Sport AWD 3.5L V6 DOHC VVT-i 24V eCVT 3.5L V6 DOHC VVT-i 24V, AWD, Black w/F SPORT NuLuxe Seat Trim. Clean...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2YGMDA4NC089623
    Stock: M7825A
    Certified Pre-Owned: No
    Listed since: 12-25-2024

    • 71,274 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Winn Volkswagen (176 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Newark, CA / 176 miles away from Reno, NV

    3.5L V6 DOHC VVT-i 24V, AWD, Black Artificial Leather.CARFAX One-Owner. Clean CARFAX. 31/28 City/Highway MPG450h 4D Sport Utility 3.5L V6 DOHC VVT-i 2...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA6NC084536
    Stock: T11936
    Certified Pre-Owned: No
    Listed since: 01-17-2025

  • Price Drop
    • 54,670 miles
    • No accidents, 1 owner, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Audi Monterey Peninsula (225 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Seaside, CA / 225 miles away from Reno, NV

    Excellent Condition, Great Price!!! Experience the perfect balance of luxury, performance, and efficiency with this Silver 2022 Lexus RX 450h AWD SUV....

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA4NC092019
    Stock: A7524A
    Certified Pre-Owned: No
    Listed since: 07-16-2025

  • Price Drop
    • 53,314 miles
    • No accidents, 2 owners, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Fresno Lexus (183 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Sunroof/Moonroof
    • Keyless Entry/Start
    Close

    Located in Fresno, CA / 183 miles away from Reno, NV

    New Price! Certified. 3.5L V6 DOHC VVT-i 24V, AWD, Black w/NuLuxe Seat Trim. 450h eCVT AWD Clean CARFAX. Eminent White Pearl 2022 Lexus RX 3.5L V6 DOH...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA7NC074033
    Stock: 25X1044A
    Certified Pre-Owned: Yes
    Listed since: 07-01-2025

  • New Listing
    • 45,000 miles
    • No accidents, 1 owner, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Shamrock Group (435 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Sunroof/Moonroof
    • Keyless Entry/Start
    Close

    Located in Pleasant Grove, UT / 435 miles away from Reno, NV

    At Shamrock Auto Group we aren't loud....WE'RE SIMPLE!! We go ABOVE & BEYOND making sure all of our cars are not just fully INSPECTED and SERVICED but...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA9NC081713
    Stock: NC081713
    Certified Pre-Owned: No
    Listed since: 05-21-2025

    • 89,811 miles
    • No accidents, 2 owners, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Driveway (249 mi away)
    • Home delivery*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Leather Seats
    Close

    Located in Medford, OR / 249 miles away from Reno, NV

    Rare Find,Green Vehicle,Back-Up Camera,Blind Spot Monitor,Bluetooth,Brake Assist,Hands-Free Liftgate,Heated Seats,Heated Steering Wheel,Keyless Start,...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2BGMCA6JC027240
    Stock: JC027240H
    Certified Pre-Owned: No

  • Price Drop
    • 116,941 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • BMW of Riverside (408 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Riverside, CA / 408 miles away from Reno, NV

    MP3, BLUETOOTH, LOCAL SOUTHERN CALIFORNIA CAR*, 3.5L V6 DOHC VVT-i 24V, AWD, Black w/NuLuxe Seat Trim, Panoramic Moonroof & Aluminum Roof Rails. 450h ...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: Yes

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA1NC090437
    Stock: WX13960
    Certified Pre-Owned: No
    Listed since: 03-13-2025

Showing 106 - 126 out of 267 listings

Consumer Reviews for the Lexus RX 450h

Read recent reviews for the Lexus RX 450h
Overall Consumer Rating
4.4 out of 5 stars33 Reviews
Write a vehicle reviewSee all 33 reviews
  • 5 star
    (67%)
  • 4 star
    (18%)
  • 3 star
    (9%)
  • 2 star
    (0%)
  • 1 star
    (6%)
5 out of 5 stars

My Atomic Silver Ride!

markh, 11/25/2019
2020 Lexus RX 450h F SPORT Performance 4dr SUV AWD (3.5L 6cyl gas/electric hybrid CVT)
I graduated from a 2017 RX 350 to the 2020 RX 450h Performance F Sport and love it! I love the feel and sound when I put it in Sport mode, but most of the time I keep it in Eco Mode for improved mileage. In Sport mode the gas pedal is soft, whereas in Eco mode it seems as the pedal is harder to push, saving fuel? The car is very similar to my 2017 inside, except the speedometer … area. There is no space under the back seats to stick my car wash rags or umbrella since the battery is in that area. (not a problem). The RX 450h has a smaller fuel tank then the RX 350 but I am getting around a 100 miles more between fill ups with the RX 450h. The only drawback is the RX 450h does require 93 octane which compared to an RX 350 that burns 87 octane there is only a slight cost savings on fuel. Currently I am getting exactly what the estimated mileage on the sticker says....
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Used 2022 Lexus RX 450h in Reno, NV Values

Estimated values
2022 Lexus RX 450h 4dr SUV AWD (3.5L 6cyl gas/electric hybrid CVT) with no options
ConditionTrade-InPrivate PartyDealer Retail
Outstanding$33,401$34,953$36,570
Clean$32,956$34,469$36,044
Average$32,214$33,662$35,168
Rough$31,250$32,613$34,029

The average list price of a used 2022 Lexus RX 450h in Reno, Nevada is $40,651. The average mileage on a used Lexus RX 450h 2022 for sale in Reno, Nevada is 56,788. Based on the average mileage of 56,788 for used 2022 Lexus RX 450h for sale in Reno, NV and using an average vehicle condition rating, which means the vehicle may have a few mechanical and/or cosmetic problems and may require a considerable amount of reconditioning, we appraise the average trade-in value of a used Lexus RX 450h 2022 in Reno, Nevada to be $32,214.

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* Delivery of any kind does not apply to Alaska and Hawaii. Contact the dealer for delivery details, restrictions and costs.