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264 listings
  • $49,998
    fair price
    $854 below market
    • 29,551 miles
    • No accidents, 1 owner, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Bill Penney Toyota (441 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Huntsville, AL / 441 miles away from Peoria, IL

    Silver 2022 Lexus RX 450h F Sport AWD eCVT 3.5L V6 DOHC VVT-i 24V 3.5L V6 DOHC VVT-i 24V, AWD, Black Artificial Leather.Recent Arrival! 31/28 City/H...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2YGMDA1NC084685
    Stock: P8283
    Certified Pre-Owned: No
    Listed since: 05-03-2025

  • Price Drop
    $42,887
    fair price
    $927 below market
    • 37,075 miles
    • No accidents, 1 owner, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Tim Short Ford of LaFollette (421 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Sunroof/Moonroof
    • Keyless Entry/Start
    Close

    Located in La Follette, TN / 421 miles away from Peoria, IL

    **ACCIDENT FREE/AUTOCHECK CERTIFIED**, **BLUETOOTH**, **FAMILY FRIENDLY**, **HEATED MIRRORS**, **HEATED STEERING WHEEL**, **HEATED/COOLED SEATS**, **K...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA8NC083629
    Stock: P7865
    Certified Pre-Owned: No
    Listed since: 03-08-2025

  • Price Drop
    $39,495
    fair price
    $32 below market
    • 61,129 miles
    • No accidents, 1 owner, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • INFINITI of Naperville (109 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Sunroof/Moonroof
    • Keyless Entry/Start
    Close

    Located in Naperville, IL / 109 miles away from Peoria, IL

    New Price! *** INFINITI CERTIFIED ***, ***APPLE CARPLAY and ANDROID AUTO***, ***BLUETOOTH/HANDSFREE CONNECTION***, ***ALL WHEEL DRIVE / 4X4***, * NEW ...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA7NC081080
    Stock: JA0722
    Certified Pre-Owned: No
    Listed since: 02-05-2025

  • New Listing
    Stock photo**
    $52,980
    fair price
    $1,123 below market
    • 15,420 miles
    • No accidents, 1 owner, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Lexus of Lexington (332 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Leather Seats
    Close

    Located in Lexington, KY / 332 miles away from Peoria, IL

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2JGMDA9NC089697
    Stock: X37609A
    Certified Pre-Owned: No
    Listed since: 05-31-2025

  • Price Drop
    • 14,297 miles
    • No accidents, 2 owners, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • CarMax (In-stock online)
    • Transfer available from CO to IL*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Federal Heights, CO / 810 miles away from Peoria, IL

    CarMax values transparency and wants you to love your next car, not settle on it. Certain vehicles may have unrepaired safety recalls. Check nhtsa.gov...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA2NC093637
    Stock: 26550007
    Certified Pre-Owned: No

  • New Listing
    $51,998
    fair price
    $1,335 above market
    • 14,596 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • CarMax (In-stock online)
    • Transfer available from CO to IL*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Littleton, CO / 811 miles away from Peoria, IL

    CarMax values transparency and wants you to love your next car, not settle on it. Certain vehicles may have unrepaired safety recalls. Check nhtsa.gov...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA2NC089068
    Stock: 27129981
    Certified Pre-Owned: No

  • New Listing
    • 57,304 miles
    • No accidents, 2 owners, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • CarMax (In-stock online)
    • Transfer available from TX to IL*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Houston, TX / 804 miles away from Peoria, IL

    CarMax values transparency and wants you to love your next car, not settle on it. Certain vehicles may have unrepaired safety recalls. Check nhtsa.gov...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA2LC044726
    Stock: 27480412
    Certified Pre-Owned: No

  • Price Drop
    $46,111
    fair price
    $45 below market
    • 38,501 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Stew Hansen's Dodge Chrysler Jeep Ram City (224 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Urbandale, IA / 224 miles away from Peoria, IL

    Stew Hansen Dodge Ram Chrysler Jeep RAM Fiat is pumped up to offer this attractive-looking 2022 Lexus RX. 450h AWD31/28 City/Highway MPGCall now to ge...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA9NC092467
    Stock: G25H0301
    Certified Pre-Owned: No
    Listed since: 04-02-2025

  • Price Drop
    $31,577
    fair price
    $1,544 above market
    • 87,297 miles
    • No accidents, 2 owners, corporate fleet vehicle
    • 5 Seats, 31 City / 28 Hwy MPG
    • Mercedes-Benz of St Charles (111 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Leather Seats
    Close

    Located in Saint Charles, IL / 111 miles away from Peoria, IL

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: No

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2BGMCA4JC024014
    Stock: Q1108
    Certified Pre-Owned: No
    Listed since: 04-13-2025

  • New Listing
    $39,906
    fair price
    $116 below market
    • 58,066 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Watertown Chrysler Dodge Jeep Ram (477 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Watertown, SD / 477 miles away from Peoria, IL

    3.5L V6 DOHC VVT-i 24V, AWD, Parchment w/Semi-Aniline Leather Seat Trim.2022 Lexus RX 450h Eminent White Pearl AWD eCVT 3.5L V6 DOHC VVT-i 24V 31...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2JGMDA9NC080692
    Stock: Z5029A
    Certified Pre-Owned: No
    Listed since: 10-20-2024

  • Price Drop
    $41,687
    good price
    $1,995 below market
    • 60,090 miles
    • 1 accident, 1 owner, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Lexus of Fort Wayne (234 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Fort Wayne, IN / 234 miles away from Peoria, IL

    2022 Lexus RX 450h Black AWDAt Bob Rohrman Dealerships Our selection is Outstanding. We believe that we truly have a certified preowned vehicle for ev...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: No

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA2NC080418
    Stock: FL1520P
    Certified Pre-Owned: No
    Listed since: 04-10-2025

  • New Listing
    • 25,410 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • CarMax (In-stock online)
    • Transfer available from CO to IL*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Colorado Springs, CO / 807 miles away from Peoria, IL

    CarMax values transparency and wants you to love your next car, not settle on it. Certain vehicles may have unrepaired safety recalls. Check nhtsa.gov...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA8NC093710
    Stock: 27084898
    Certified Pre-Owned: No

  • Price Drop
    $45,101
    fair price
    $754 above market
    • 50,687 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • McLaughlin Cadillac (70 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    Close

    Located in Moline, IL / 70 miles away from Peoria, IL

    2022 Lexus RX 450h Black AWD eCVT 3.5L V6 DOHC VVT-i 24V3.5L V6 DOHC VVT-i 24V, AWD, Birch Artificial Leather, 4-Wheel Disc Brakes, ABS brakes, Alloy ...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA0NC078151
    Stock: C2582A
    Certified Pre-Owned: No
    Listed since: 03-10-2025

  • New Listing
    $47,395
    fair price
    $160 above market
    • 28,831 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Jackie Cooper INFINITI (464 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Tulsa, OK / 464 miles away from Peoria, IL

    The 2022 Lexus RX 450h is a luxury midsize hybrid SUV that offers a smooth, fuel-efficient ride with upscale comfort. It features a 3.5L V6 hybrid pow...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA1NC090468
    Stock: MS90468A
    Certified Pre-Owned: No
    Listed since: 03-22-2025

  • New Listing
    $42,929
    fair price
    $918 below market
    • 54,715 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Georgetown Auto Sales (321 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    Close

    Located in Georgetown, KY / 321 miles away from Peoria, IL

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA2NC072402
    Stock: G8353
    Certified Pre-Owned: No
    Listed since: 12-16-2024

  • New Listing
    $49,990
    fair price
    $1,402 above market
    • 29,655 miles
    • No accidents, 1 owner, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Carvana (In-stock online)
    • Home delivery*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Birmingham, AL / 517 miles away from Peoria, IL

    At Carvana, we go miles beyond the extra mile. That's why we provide you with a convenient, fast, and hassle-free car buying experience that puts you ...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2JGMDA9NC081163
    Stock: 2003713293
    Certified Pre-Owned: No
    Listed since: 05-07-2025

  • New Listing
    Stock photo**
    $50,000
    fair price
    $560 below market
    • 34,274 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Lexus of Dayton (297 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Leather Seats
    Close

    Located in Centerville, OH / 297 miles away from Peoria, IL

    ** LEXUS OF DAYTON, A SERVICE COMPANY THAT SELLS GREAT CARS. Experience our commitment to providing you the best possible service.** VERY NICE LUXURY ...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2JGMDA1NC081240
    Stock: ANC081240
    Certified Pre-Owned: No
    Listed since: 06-01-2025

  • Price Drop
    $39,888
    fair price
    $157 below market
    • 33,431 miles
    • 1 accident, 2 owners, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Car Town Kia USA (332 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    Close

    Located in Nicholasville, KY / 332 miles away from Peoria, IL

    Summary2020 Lexus RX 350 AWD Luxury, Reliability, and Value!Experience the perfect blend of comfort, performance, and peace of mind with this stunning...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: No

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA6LC049153
    Stock: 15954
    Certified Pre-Owned: No
    Listed since: 05-24-2025

  • $45,998
    fair price
    $143 above market
    • 40,362 miles
    • No accidents, 1 owner, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • CarMax (In-stock online)
    • Transfer available from PA to IL*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    Close

    Located in Mechanicsburg, PA / 665 miles away from Peoria, IL

    CarMax values transparency and wants you to love your next car, not settle on it. Certain vehicles may have unrepaired safety recalls. Check nhtsa.gov...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA9NC092307
    Stock: 27459841
    Certified Pre-Owned: No

  • $45,901
    fair price
    $1,116 above market
    • 47,999 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Nelson Mazda Tulsa (465 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Tulsa, OK / 465 miles away from Peoria, IL

    Recent Arrival!Blue 2022 Lexus RX 450h 4D Sport Utility AWD 3.5L V6 DOHC VVT-i 24V eCVT 31/28 City/Highway MPG CARFAX One-Owner.NON-Commissioned Sales...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA1NC088932
    Stock: P18048
    Certified Pre-Owned: No
    Listed since: 04-26-2025

    • 9,776 miles
    • No accidents, 2 owners, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Auffenberg Chrysler Dodge Jeep Ram (144 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Shiloh, IL / 144 miles away from Peoria, IL

    Clean CARFAX. 2022 Lexus RX 450h 3.5L V6 DOHC VVT-i 24V eCVT AWD 4D Sport Utility Caviar 31/28 City/Highway MPG ***ONE OWNER, LOCAL TRADE, CLEAN CARFA...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2JGMDA6NC079788
    Stock: 10520N
    Certified Pre-Owned: No
    Listed since: 05-19-2025

Showing 64 - 84 out of 264 listings

Consumer Reviews for the Lexus RX 450h

Read recent reviews for the Lexus RX 450h
Overall Consumer Rating
4.4 out of 5 stars33 Reviews
Write a vehicle reviewSee all 33 reviews
  • 5 star
    (67%)
  • 4 star
    (18%)
  • 3 star
    (9%)
  • 2 star
    (0%)
  • 1 star
    (6%)
5 out of 5 stars

My Atomic Silver Ride!

markh, 11/25/2019
2020 Lexus RX 450h F SPORT Performance 4dr SUV AWD (3.5L 6cyl gas/electric hybrid CVT)
I graduated from a 2017 RX 350 to the 2020 RX 450h Performance F Sport and love it! I love the feel and sound when I put it in Sport mode, but most of the time I keep it in Eco Mode for improved mileage. In Sport mode the gas pedal is soft, whereas in Eco mode it seems as the pedal is harder to push, saving fuel? The car is very similar to my 2017 inside, except the speedometer … area. There is no space under the back seats to stick my car wash rags or umbrella since the battery is in that area. (not a problem). The RX 450h has a smaller fuel tank then the RX 350 but I am getting around a 100 miles more between fill ups with the RX 450h. The only drawback is the RX 450h does require 93 octane which compared to an RX 350 that burns 87 octane there is only a slight cost savings on fuel. Currently I am getting exactly what the estimated mileage on the sticker says....
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Used 2022 Lexus RX 450h in Peoria, IL Values

Estimated values
2022 Lexus RX 450h F SPORT Handling 4dr SUV AWD (3.5L 6cyl gas/electric hybrid CVT) with no options
ConditionTrade-InPrivate PartyDealer Retail
Outstanding$35,886$38,269$40,754
Clean$35,408$37,739$40,168
Average$34,611$36,855$39,191
Rough$33,575$35,707$37,922

The average list price of a used 2022 Lexus RX 450h in Peoria, Illinois is $45,482. The average mileage on a used Lexus RX 450h 2022 for sale in Peoria, Illinois is 39,451. Based on the average mileage of 39,451 for used 2022 Lexus RX 450h for sale in Peoria, IL and using an average vehicle condition rating, which means the vehicle may have a few mechanical and/or cosmetic problems and may require a considerable amount of reconditioning, we appraise the average trade-in value of a used Lexus RX 450h 2022 in Peoria, Illinois to be $34,611.

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* Delivery of any kind does not apply to Alaska and Hawaii. Contact the dealer for delivery details, restrictions and costs.