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245 listings
  • Price Drop
    $44,800
    good price
    $2,583 below market
    • 37,903 miles
    • No accidents, 1 owner, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Lexus of Oxnard (183 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Sunroof/Moonroof
    • Keyless Entry/Start
    Close

    Located in Oxnard, CA / 183 miles away from Fresno, CA

    **SPRING INTO SAVINGS SALES EVENT GOING ON NOW!**2022 Lexus RX 450h3.5L V6 DOHC VVT-i 24V, AWD, Black w/NuLuxe Seat Trim.Priced below KBB Fair Pu...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA9NC078505
    Stock: L8382T
    Certified Pre-Owned: Yes
    Listed since: 04-28-2025

  • Price Drop
    $27,951
    fair price
    $98 above market
    • 101,303 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Lexus of Cerritos (227 mi away)
    • Five Star Dealer
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Leather Seats
    Close

    Located in Cerritos, CA / 227 miles away from Fresno, CA

    Navigation W/12.3" Multimedia DisplayPower Tilt & Slide Sun/Moon RoofWheels: 20" High GlossPremium PackageBlind Spot Monitor W/Rear Cross Traffic ...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2BGMCA6JC024371
    Stock: JC024371
    Certified Pre-Owned: No
    Listed since: 04-22-2025

  • $54,304
    fair price
    $788 below market
    • 16,293 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • CarXchange (213 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Victorville, CA / 213 miles away from Fresno, CA

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2YGMDA5NC086777
    Stock: 2504509
    Certified Pre-Owned: No
    Listed since: 04-10-2025

  • $53,688
    fair price
    $752 below market
    • 16,387 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Toyota Place (236 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Garden Grove, CA / 236 miles away from Fresno, CA

    Toyota Place is proud to offer our. 2022 Lexus RX 450h F Sport AWDCARFAX One-Owner. Caviar 12.3" Navigation System w/Mark Levinson Audio, Adaptive Var...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2YGMDA3NC090570
    Stock: T090570
    Certified Pre-Owned: No
    Listed since: 04-30-2025

  • Price Drop
    $51,998
    fair price
    $756 above market
    • 14,596 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • CarMax (In-stock online)
    • Transfer available from CO to CA*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Littleton, CO / 828 miles away from Fresno, CA

    CarMax values transparency and wants you to love your next car, not settle on it. Certain vehicles may have unrepaired safety recalls. Check nhtsa.gov...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA2NC089068
    Stock: 27129981
    Certified Pre-Owned: No

  • Price Drop
    $49,443
    fair price
    $208 below market
    • 23,694 miles
    • No accidents, 2 owners, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Audi Fremont (127 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Fremont, CA / 127 miles away from Fresno, CA

    *Audi Fremont does not reserve, or hold advertised vehicles, all are subject to prior sale on a ...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA6NC077442
    Stock: U4780
    Certified Pre-Owned: No
    Listed since: 05-06-2025

  • Price Drop
    $28,990
    good price
    $1,098 below market
    • 82,353 miles
    • No accidents, 2 owners, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Carvana - Sacramento (143 mi away)
    • Home delivery*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Leather Seats
    Close

    Located in Sacramento, CA / 143 miles away from Fresno, CA

    At Carvana, we go miles beyond the extra mile. That's why we provide you with a convenient, fast, and hassle-free car buying experience that puts you ...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2BGMCA7JC024041
    Stock: 2003693481
    Certified Pre-Owned: No
    Listed since: 05-13-2025

  • Price Drop
    $30,875
    fair price
    $96 below market
    • 86,359 miles
    • 1 accident, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Tustin Lexus (243 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Leather Seats
    Close

    Located in Tustin, CA / 243 miles away from Fresno, CA

    Heated/Cooled Leather Seats, Moonroof, Navigation, Heated Rear Seat, All Wheel Drive, Aluminum Wheels, 12.3 NAVIGATION SYSTEM W/MARK LEVINS... PANORAM...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: No

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2BGMCA9JC026390
    Stock: JC026390
    Certified Pre-Owned: No
    Listed since: 04-17-2025

  • New Listing
    $49,998
    fair price
    $1,089 above market
    • 25,410 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • CarMax (In-stock online)
    • Transfer available from CO to CA*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Colorado Springs, CO / 836 miles away from Fresno, CA

    CarMax values transparency and wants you to love your next car, not settle on it. Certain vehicles may have unrepaired safety recalls. Check nhtsa.gov...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA8NC093710
    Stock: 27084898
    Certified Pre-Owned: No

  • Price Drop
    $51,590
    fair price
    $1,551 below market
    • 28,511 miles
    • No accidents, 2 owners, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Carvana (In-stock online)
    • Home delivery*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Philadelphia, PA / 2,406 miles away from Fresno, CA

    At Carvana, we go miles beyond the extra mile. That's why we provide you with a convenient, fast, and hassle-free car buying experience that puts you ...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2JGMDA9NC077243
    Stock: 2003709137
    Certified Pre-Owned: No
    Listed since: 05-02-2025

  • Price Drop
    $45,999
    good price
    $1,676 below market
    • 29,917 miles
    • No accidents, 1 owner, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Shottenkirk Desert Lexus (283 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Cathedral City, CA / 283 miles away from Fresno, CA

    CARFAX One-Owner. Clean CARFAX. Priced below KBB Fair Purchase Price! RX 450h, 4D Sport Utility, 3.5L V6 DOHC VVT-i 24V, eCVT, AWD, Caviar, Black w/Nu...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA1NC074478
    Stock: 29159
    Certified Pre-Owned: No
    Listed since: 11-02-2024

  • New Listing
    • 29,876 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • CarMax (In-stock online)
    • Transfer available from TX to CA*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Corpus Christi, TX / 1,453 miles away from Fresno, CA

    CarMax values transparency and wants you to love your next car, not settle on it. Certain vehicles may have unrepaired safety recalls. Check nhtsa.gov...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA0NC077999
    Stock: 26403175
    Certified Pre-Owned: No

  • $52,995
    fair price
    $441 below market
    • 21,606 miles
    • No accidents, 1 owner, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Shottenkirk Desert Lexus (283 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Cathedral City, CA / 283 miles away from Fresno, CA

    CARFAX One-Owner. Clean CARFAX. Priced below KBB Fair Purchase Price! RX 450h F Sport, 4D Sport Utility, 3.5L V6 DOHC VVT-i 24V, eCVT, AWD, Caviar, Bl...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2YGMDA0NC082068
    Stock: 441323A
    Certified Pre-Owned: No
    Listed since: 01-29-2025

  • $44,998
    fair price
    $771 below market
    • 54,382 miles
    • No accidents, 1 owner, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Mercedes-Benz of Palo Alto (133 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Palo Alto, CA / 133 miles away from Fresno, CA

    OPTION PACKAGES12 speakers w/subwoofer, Auto Recirculation Air Conditioner, Intuitive Parking Assist, MOONROOF & ALUMINUM ROOF RAILS, Machine surfacin...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA8NC087518
    Stock: C087518T
    Certified Pre-Owned: No
    Listed since: 05-03-2025

  • $41,999
    fair price
    $69 below market
    • 35,913 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Simi Valley Toyota (186 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Simi Valley, CA / 186 miles away from Fresno, CA

    Clean CARFAX. Recent Arrival! CARFAX One-Owner. Odometer is 14691 miles below market average!31/28 City/Highway MPGBIGGEST PRE-OWNED SALE OF THE YE...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA8LC050269
    Stock: K3268
    Certified Pre-Owned: No
    Listed since: 05-18-2025

  • $44,498
    fair price
    $283 below market
    • 44,773 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • High Class Auto Sales (144 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Rancho Cordova, CA / 144 miles away from Fresno, CA

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA1NC093905
    Stock: 093905
    Certified Pre-Owned: No

  • Price Drop
    $44,995
    good price
    $1,643 below market
    • 45,956 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Shottenkirk Desert Lexus (283 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Cathedral City, CA / 283 miles away from Fresno, CA

    CARFAX One-Owner. Clean CARFAX. RX 450h, 4D Sport Utility, 3.5L V6 DOHC VVT-i 24V, eCVT, AWD, Atomic Silver, Parchment w/NuLuxe Seat Trim, 3.54 Axle R...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA6NC094757
    Stock: 450620A
    Certified Pre-Owned: No
    Listed since: 05-10-2025

    • 14,297 miles
    • No accidents, 2 owners, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • CarMax (In-stock online)
    • Transfer available from CO to CA*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Federal Heights, CO / 830 miles away from Fresno, CA

    CarMax values transparency and wants you to love your next car, not settle on it. Certain vehicles may have unrepaired safety recalls. Check nhtsa.gov...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA2NC093637
    Stock: 26550007
    Certified Pre-Owned: No

  • Price Drop
    $48,488
    fair price
    $19 above market
    • 28,772 miles
    • No accidents, 1 owner, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Epic Chevrolet (150 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    Close

    Located in Sacramento, CA / 150 miles away from Fresno, CA

    Epic Chevrolet Cadillac is the largest new and preowned volume dealership in Sacramento. We are family owned and operated without the auto mall drama....

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA5NC089887
    Stock: 26D010A
    Certified Pre-Owned: No
    Listed since: 05-10-2025

  • New Listing
    Stock photo**
    $52,991
    fair price
    $430 above market
    • 11,276 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Lexus of Thousand Oaks (192 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    Close

    Located in Thousand Oaks, CA / 192 miles away from Fresno, CA

    OPTION PACKAGES12.3 NAVIGATION SYSTEM 12 speakers w/subwoofer, Auto Recirculation Air Conditioner, PANORAMIC-VIEW MONITOR W/RR CROSS-TRAFFIC BRAKING I...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA7NC087428
    Stock: C087428T
    Certified Pre-Owned: Yes
    Listed since: 05-27-2025

  • New Listing
    Stock photo**
    $41,777
    fair price
    $1,192 below market
    • 72,006 miles
    • No accidents, 1 owner, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Lexus of Henderson (273 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Sunroof/Moonroof
    • Keyless Entry/Start
    Close

    Located in Henderson, NV / 273 miles away from Fresno, CA

    Recent Arrival! LEXUS CERTIFIED, APPLE CAR PLAY, ANDROID AUTO, L/Certified Certified, 3.5L V6 DOHC VVT-i 24V, AWD, Black w/NuLuxe Seat Trim, Alloy whe...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA2NC082475
    Stock: 0P250057
    Certified Pre-Owned: Yes
    Listed since: 03-27-2025

Showing 64 - 84 out of 245 listings

Consumer Reviews for the Lexus RX 450h

Read recent reviews for the Lexus RX 450h
Overall Consumer Rating
4.4 out of 5 stars33 Reviews
Write a vehicle reviewSee all 33 reviews
  • 5 star
    (67%)
  • 4 star
    (18%)
  • 3 star
    (9%)
  • 2 star
    (0%)
  • 1 star
    (6%)
5 out of 5 stars

My Atomic Silver Ride!

markh, 11/25/2019
2020 Lexus RX 450h F SPORT Performance 4dr SUV AWD (3.5L 6cyl gas/electric hybrid CVT)
I graduated from a 2017 RX 350 to the 2020 RX 450h Performance F Sport and love it! I love the feel and sound when I put it in Sport mode, but most of the time I keep it in Eco Mode for improved mileage. In Sport mode the gas pedal is soft, whereas in Eco mode it seems as the pedal is harder to push, saving fuel? The car is very similar to my 2017 inside, except the speedometer … area. There is no space under the back seats to stick my car wash rags or umbrella since the battery is in that area. (not a problem). The RX 450h has a smaller fuel tank then the RX 350 but I am getting around a 100 miles more between fill ups with the RX 450h. The only drawback is the RX 450h does require 93 octane which compared to an RX 350 that burns 87 octane there is only a slight cost savings on fuel. Currently I am getting exactly what the estimated mileage on the sticker says....
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Used 2022 Lexus RX 450h in Fresno, CA Values

Estimated values
2022 Lexus RX 450h 4dr SUV AWD (3.5L 6cyl gas/electric hybrid CVT) with no options
ConditionTrade-InPrivate PartyDealer Retail
Outstanding$34,617$35,592$36,606
Clean$34,156$35,099$36,080
Average$33,387$34,277$35,203
Rough$32,388$33,209$34,062

The average list price of a used 2022 Lexus RX 450h in Fresno, California is $45,923. The average mileage on a used Lexus RX 450h 2022 for sale in Fresno, California is 39,123. Based on the average mileage of 39,123 for used 2022 Lexus RX 450h for sale in Fresno, CA and using an average vehicle condition rating, which means the vehicle may have a few mechanical and/or cosmetic problems and may require a considerable amount of reconditioning, we appraise the average trade-in value of a used Lexus RX 450h 2022 in Fresno, California to be $33,387.

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* Delivery of any kind does not apply to Alaska and Hawaii. Contact the dealer for delivery details, restrictions and costs.