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206 listings
  • New Listing
    • 46,886 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • CarMax Louisville (485 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Louisville, KY / 485 miles away from Des Moines, IA

    CarMax values transparency and wants you to love your next car, not settle on it. Certain vehicles may have unrepaired safety recalls. Check nhtsa.gov...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA2NC078801
    Stock: 26483002
    Certified Pre-Owned: No

  • New Listing
    • 49,587 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Carvana (In-stock online)
    • Home delivery*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Sunroof/Moonroof
    • Keyless Entry/Start
    Close

    Located in Columbus, OH / 565 miles away from Des Moines, IA

    At Carvana, we go miles beyond the extra mile. That's why we provide you with a convenient, fast, and hassle-free car buying experience that puts you ...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA2LC052888
    Stock: 2003724641
    Certified Pre-Owned: No
    Listed since: 05-08-2025

    • 49,469 miles
    • No accidents, 2 owners, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • McGrath Lexus of Westmont (291 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Leather Seats
    Close

    Located in Westmont, IL / 291 miles away from Des Moines, IA

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2BGMCA9JC028592
    Stock: P16448
    Certified Pre-Owned: No
    Listed since: 05-15-2025

    • 58,993 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • McGrath Lexus of Westmont (291 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Westmont, IL / 291 miles away from Des Moines, IA

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2BGMCA8JC023111
    Stock: D2427A
    Certified Pre-Owned: No
    Listed since: 05-17-2025

  • New Listing
    • 29,833 miles
    • 5 Seats, 31 City / 28 Hwy MPG
    • Mungenast Lexus of St Louis (265 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Manchester, MO / 265 miles away from Des Moines, IA

    Recent Arrival! 31/28 City/Highway MPG Mungenast Makes the Difference. Matador Red Mica 2022 Lexus RX 450h AWD eCVT 3.5L V6 DOHC VVT-i 24V Please call...

    AutoCheck Vehicle History Summary Unavailable.

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2JGMDA6NC087258
    Stock: P1405
    Certified Pre-Owned: No
    Listed since: 06-02-2025

    • 76,171 miles
    • 1 accident, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Toyota of Grand Rapids (418 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Leather Seats
    Close

    Located in Grand Rapids, MI / 418 miles away from Des Moines, IA

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: No

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2BGMCA7JC027702
    Stock: T8807
    Certified Pre-Owned: No
    Listed since: 04-17-2025

  • New Listing
    $39,987
    great price
    $5,045 below market
    • 54,538 miles
    • No accidents, 1 owner, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Car Chase (247 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in O'Fallon, MO / 247 miles away from Des Moines, IA

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2JGMDA9MC067360
    Stock: 067360
    Certified Pre-Owned: No
    Listed since: 05-19-2025

  • New Listing
    • 33,777 miles
    • 5 Seats, 31 City / 28 Hwy MPG
    • Tom Wood Volkswagen (409 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Indianapolis, IN / 409 miles away from Des Moines, IA

    2022 Lexus RX 450h Clean CARFAX. Odometer is 7837 miles below market average! *LIFETIME POWERTRAIN COVERAGE*, *LEATHER SEATS*, *HEATED FRONT SEATS*, *...

    AutoCheck Vehicle History Summary Unavailable.

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2JGMDA3NC087556
    Stock: VIP087556
    Certified Pre-Owned: No
    Listed since: 06-03-2025

  • Price Drop
    $41,495
    good price
    $2,817 below market
    • 31,586 miles
    • No accidents, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Frank Boucher Kia (301 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Racine, WI / 301 miles away from Des Moines, IA

    All Wheel Drive, 18" x 8" Aluminum Wheels, AM/FM/CD Radio, Apple CarPlay/Android Auto, Auto Tilt-Away Steering Wheel, Auto-Dimming Heated Door Mirrors...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA6MC067699
    Stock: PD14232
    Certified Pre-Owned: No
    Listed since: 02-25-2025

  • $18,908
    fair price
    $557 below market
    • 113,677 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 30 City / 28 Hwy MPG
    • Lexus of Orland (298 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Power Driver Seat
    • Tire Pressure Warnin...
    Close

    Located in Orland Park, IL / 298 miles away from Des Moines, IA

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    29 Combined MPG (30 City/28 Highway)

    Listing Information:

    VIN: 2T2BC1BA7FC003273
    Stock: LX07101
    Certified Pre-Owned: No
    Listed since: 05-23-2025

  • Price Drop
    $39,821
    good price
    $2,076 below market
    • 49,123 miles
    • No accidents, 1 owner, corporate fleet vehicle
    • 5 Seats, 31 City / 28 Hwy MPG
    • Lexus of Fort Wayne (436 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Fort Wayne, IN / 436 miles away from Des Moines, IA

    2021 Lexus RX 450h Black AWDAt Bob Rohrman Dealerships Our selection is Outstanding. We believe that we truly have a certified preowned vehicle for ev...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: No

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2JGMDA0MC069160
    Stock: FL1512P
    Certified Pre-Owned: No
    Listed since: 04-22-2025

  • $25,200
    fair price
    $367 below market
    • 103,247 miles
    • No accidents, 2 owners, corporate fleet vehicle
    • 5 Seats, 31 City / 28 Hwy MPG
    • Spirit Lexus (263 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Leather Seats
    Close

    Located in St. Louis, MO / 263 miles away from Des Moines, IA

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: No

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2BGMCA5HC014988
    Stock: P3U014988
    Certified Pre-Owned: No
    Listed since: 03-22-2025

  • $23,982
    fair price
    $825 below market
    • 106,529 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Driveway (In-stock online)
    • Home delivery*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Leather Seats
    Close

    Located in Ramsey, NJ / 1,008 miles away from Des Moines, IA

    CarFax No Accidents Reported,CarFax 1-Owner,Rare Find,Green Vehicle,Back-Up Camera,Blind Spot Monitor,Bluetooth,Brake Assist,Hands-Free Liftgate,Heate...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2BGMCA0HC013831
    Stock: L17434T
    Certified Pre-Owned: No

  • New Listing
    $41,590
    good price
    $1,316 below market
    • 44,167 miles
    • 1 accident, 2 owners, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Carvana (In-stock online)
    • Home delivery*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Cleveland, OH / 614 miles away from Des Moines, IA

    At Carvana, we go miles beyond the extra mile. That's why we provide you with a convenient, fast, and hassle-free car buying experience that puts you ...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: No

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2YGMDAXMC061856
    Stock: 2003667919
    Certified Pre-Owned: No
    Listed since: 04-29-2025

  • $24,995
    fair price
    $452 below market
    • 47,920 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 30 City / 28 Hwy MPG
    • Sunset Ford (272 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Power Driver Seat
    • Tire Pressure Warnin...
    Close

    Located in Saint Louis, MO / 272 miles away from Des Moines, IA

    This vehicle is a certified CARFAX 1-owner. Our dealership has already run the CARFAX report and it is clean. A clean CARFAX is a great asset for res...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    29 Combined MPG (30 City/28 Highway)

    Listing Information:

    VIN: 2T2BC1BA3FC008440
    Stock: T72526A
    Certified Pre-Owned: No
    Listed since: 05-21-2025

  • New Listing
    $32,998
    good price
    $1,570 below market
    • 44,800 miles
    • 1 accident, 1 owner, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • CarMax (In-stock online)
    • Transfer available from CA to IA*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Leather Seats
    Close

    Located in Fresno, CA / 1,435 miles away from Des Moines, IA

    CarMax values transparency and wants you to love your next car, not settle on it. Certain vehicles may have unrepaired safety recalls. Check nhtsa.gov...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: No

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2BGMCA6HC010416
    Stock: 27477113
    Certified Pre-Owned: No

  • New Listing
    $20,440
    fair price
    $494 above market
    • 108,106 miles
    • No accidents, 2 owners, personal use only
    • 5 Seats, 30 City / 28 Hwy MPG
    • Mungenast Lexus of St Louis (265 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Power Driver Seat
    • Tire Pressure Warnin...
    Close

    Located in Manchester, MO / 265 miles away from Des Moines, IA

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    29 Combined MPG (30 City/28 Highway)

    Listing Information:

    VIN: 2T2BC1BA0FC009724
    Stock: P1398
    Certified Pre-Owned: No
    Listed since: 05-29-2025

    • 103,130 miles
    • No accidents, 3 owners, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • CarMax (In-stock online)
    • Transfer available from TX to IA*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Leather Seats
    Close

    Located in Houston, TX / 816 miles away from Des Moines, IA

    CarMax values transparency and wants you to love your next car, not settle on it. Certain vehicles may have unrepaired safety recalls. Check nhtsa.gov...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2BGMCA8HC009882
    Stock: 27011305
    Certified Pre-Owned: No

  • $43,998
    fair price
    $527 above market
    • 50,043 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • CarMax (In-stock online)
    • Transfer available from GA to IA*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Columbus, GA / 786 miles away from Des Moines, IA

    CarMax values transparency and wants you to love your next car, not settle on it. Certain vehicles may have unrepaired safety recalls. Check nhtsa.gov...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2JGMDA0MC068459
    Stock: 26828017
    Certified Pre-Owned: No

    • 25,837 miles
    • 1 accident, 1 owner, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Driveway (In-stock online)
    • Home delivery*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Houston, TX / 815 miles away from Des Moines, IA

    Low Mileage,Rare Find,Green Vehicle,Apple CarPlay,Back-Up Camera,Blind Spot Monitor,Bluetooth,Brake Assist,Heated Seats,Heated Steering Wheel,Keyless ...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: No

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA2MC069174
    Stock: MC069174P
    Certified Pre-Owned: No

  • New Listing
    $25,998
    fair price
    $659 above market
    • 104,974 miles
    • 5 Seats, 31 City / 28 Hwy MPG
    • CarMax (In-stock online)
    • Transfer available from CA to IA*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Leather Seats
    Close

    Located in Modesto, CA / 1,476 miles away from Des Moines, IA

    CarMax values transparency and wants you to love your next car, not settle on it. Certain vehicles may have unrepaired safety recalls. Check nhtsa.gov...

    AutoCheck Vehicle History Summary Unavailable.

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2BGMCA4HC011645
    Stock: 27296407
    Certified Pre-Owned: No

Showing 64 - 84 out of 206 listings

Consumer Reviews for the Lexus RX 450h

Read recent reviews for the Lexus RX 450h
Overall Consumer Rating
4.4 out of 5 stars35 Reviews
Write a vehicle reviewSee all 35 reviews
  • 5 star
    (69%)
  • 4 star
    (11%)
  • 3 star
    (11%)
  • 2 star
    (6%)
  • 1 star
    (3%)
5 out of 5 stars

Best Family SUV for the Money

Emre Afsar, 08/09/2018
2018 Lexus RX 450h 4dr SUV AWD (3.5L 6cyl gas/electric hybrid CVT)
I am an enthusiast and shopped for months for a larger family SUV. In terms of comfort, space, and fuel economy there is nothing in the market that comes close to the RX 450h. It feels solid and substantial behind the wheel. Effortless steering and acceleration, great visibility thanks to the A pillar and side mirror design. Whisper quiet at any speed and the hybrid powertrain works … seamlessly. Definitely go with the upgraded 12.3 inch infotainment system as it has better input method with the joystick (as oppose to the wheel controller on the base system) and the definition of the screen is very high. Averaging 32 MPG on our first tank so far with the AC on all the time. Speaking of which it is the best AC system I have experienced in any car. Works in conjunction with the heated/ventilated seats and cools the cabin incredibly fast and works super quiet. No negatives or complaints so far, an excellent luxury mid-size SUV. Highly recommended!
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Used 2022 Lexus RX 450h in Des Moines, IA Values

Estimated values
2022 Lexus RX 450h 4dr SUV AWD (3.5L 6cyl gas/electric hybrid CVT) with no options
ConditionTrade-InPrivate PartyDealer Retail
Outstanding$28,519$29,374$30,265
Clean$28,139$28,968$29,830
Average$27,505$28,289$29,105
Rough$26,682$27,408$28,162

The average list price of a used 2022 Lexus RX 450h in Des Moines, Iowa is $34,883. The average mileage on a used Lexus RX 450h 2022 for sale in Des Moines, Iowa is 63,447. Based on the average mileage of 63,447 for used 2022 Lexus RX 450h for sale in Des Moines, IA and using an average vehicle condition rating, which means the vehicle may have a few mechanical and/or cosmetic problems and may require a considerable amount of reconditioning, we appraise the average trade-in value of a used Lexus RX 450h 2022 in Des Moines, Iowa to be $27,505.

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* Delivery of any kind does not apply to Alaska and Hawaii. Contact the dealer for delivery details, restrictions and costs.