I've had my TSX for 5 years now, and I still love driving it. The car handles as well as when I first bought it - actually better since I replaced the stock tires 10,000 miles ago. It is fun to drive with a comfortable and intuitive interior that hasn't shown much wear. According to Edmunds' used car appraiser, it has held its value well also. With a new baby on the way, my wife and I are currently battling about which car to replace - her 2003 Passat, or my TSX. My only TSX-related complaint is that Acura/Honda doesn't make a wagon version. We'll look at the RDX, but a TSX/TL/Accord wagon is really what we'd prefer. It's been a good buy.
Besides the prestine handling, the dual-zone auto climate control and auto-dimming mirror work perfectly - I'll never buy another car without them. I've never been in another car that equals the climate control of my TSX - you simply never have to think about it.
Memory seats (which they did add later) are an odd omission. Offer a wagon!