I just bought the RX 350 three weeks ago and I absolutely love it. I live in Pittsburgh and was able to test it out in the last snow/ice storm we had, and the car performed admirably. I couldn't be happier with it. Lots of cabin room, seating 4 or 5 is comfortable. Very good with pick-up, given that the V6 puts out 270 hp, and the RX's competitors are all V8s (easier on the wallet with gas too).
Navigation system is really user friendly, and incredibly comprehensive and accurate. Ride is so smooth for an SUV. Black birds-eye maple interior was a great touch.
Maybe a bit more room in the trunk, but it is by no means inadequate.