Owned three MB E 350 class cars that were good cars. I then traded in my 2015 RX-350 AWD, which was also a very nice car, for the 2016 LS 460. By any means, the LS 460 was the nicest car I have ever owned. The quiet comfort, quality, amenities and performance are superb. This car compares favorably to the MB S Class at about $25000.00 less, and is a lot more dependable. Low speed acceleration is acceptable, but high speed acceleration above 70mph is superb. Gas mileage however is poor, depending on the way you drive. Steering feel is better than any Mercedes, and body lean is also better. The infotainment system in the Mercedes was easier to use, but after some getting used to it, the mouse control in the Lexus becomes more user friendly. The voice command works quite well, and the Lexus Enform Apps are great.
Had two Infiniti Q-45 V-8 cars which were really fun to drive, especially the second sport model. Lexus LS much quieter with easier steering, not as sporty, but more comfortable. Lots of new electronics, especially huge view screen. Ventilated front seats wonderful in desert weather. Very firm lumbar support which is a bit low for my back, despite height adjustment. Have never found a comfortable German car except Mercedes S-class, which rode like a Chevrolet and was severely underpowered. Don't understand the previous review. This is the nicest car I've ever owned! Considered the F sport model, but almost all have black seats, not the best in 110 degree summers. A few mechanical problems with side mirrors, driver's seat memory(occasional).
Loved my 1998, thought upgrading to get new technology would be an improvement. But so many things have been disappointing. The navigation system is a disaster with the remote mouse. BMW/Mercedes/Audi iDrive like are much easier to use. Forget about voice control. Doesn't work. Keyless entry sometimes works, sometimes doesn't. Impossible to debug because it is intermittent. Have the F Sport, where the front seats are very uncomfortable -- back is too narrow unless you're a very small person. Both BMW and Mercedes have adjustments. Lexus doesn't. Also so many features that the german cars have and Lexus doesn't in this flagship car- massage front seats, contour seats, self parking, surround cameras.
The "mouse" for navigating the control panel is very awkward and the menus are complicated and illogical. No place for a coffee mug! Has two narrow coffee/drink holders, but cannot put a mug with an "ear" and cannot remove bottom to clean it.
the front seats are impossible to adjust properly plus I've sat on rocks that are more comfortable. owned many Lexus this is the most uncomfortable car I've ever driven. doesn't show up on the test drive but drive it for an hour and you can't wait to get out of it.