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1,515 listings
- $43,499great price$3,653 below market
- 14,380 miles
- 1 accident, 1 owner, personal use only
- 5 Seats, 19 City / 26 Hwy MPG
- Lexus of Brookfield (297 mi away)
- Five Star Dealer
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Located in Brookfield, WI / 297 miles away from Des Moines, IA
Cold Weather Package!F Sport!12.3" Touchscreen Navigation!Color Heads Up Display!**L/Certified** CARFAX One-Owner. Certified. Ultra White 2021...
AutoCheck Vehicle History Summary
Accident Free Vehicle: No
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2SZMDA4MC283356
Stock: 28522A
Certified Pre-Owned: Yes
Listed since: 08-22-2025 - Price Drop$39,166good price$2,373 below market
- 30,660 miles
- No accidents, 1 owner, personal use only
- 5 Seats, 19 City / 26 Hwy MPG
- Porsche St. Louis (270 mi away)
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Located in Saint Louis, MO / 270 miles away from Des Moines, IA
Porsche St. Louis is proud to present this Pre-Owned 2021 Lexus RX 350 AWD. Dressed in elegant Nebula Gray Pearl and paired with a refined interior, t...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA8MC268482
Stock: TMC268482
Certified Pre-Owned: No
Listed since: 08-21-2025 - Price Drop$36,990good price$917 below market
- 39,910 miles
- No accidents, 2 owners, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- Carvana - Chicago (273 mi away)
- Home delivery*
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Located in Chicago, IL / 273 miles away from Des Moines, IA
At Carvana, we go miles beyond the extra mile. That's why we provide you with a convenient, fast, and hassle-free car buying experience that puts you ...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA9MC278101
Stock: 2003944118
Certified Pre-Owned: No
Listed since: 08-14-2025 - Price Drop$36,990good price$1,379 below market
- 37,657 miles
- No accidents, 1 owner, personal use only
- 5 Seats, 19 City / 26 Hwy MPG
- Carvana - Chicago (273 mi away)
- Home delivery*
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Located in Chicago, IL / 273 miles away from Des Moines, IA
At Carvana, we go miles beyond the extra mile. That's why we provide you with a convenient, fast, and hassle-free car buying experience that puts you ...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDAXMC270086
Stock: 2004017222
Certified Pre-Owned: No
Listed since: 08-28-2025 - $39,000fair price$638 below market
- 58,521 miles
- No accidents, 1 owner, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- Lexus of Highland Park (301 mi away)
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Located in Highland Park, IL / 301 miles away from Des Moines, IA
For sale is a Lexus Certified 2021 Lexus RX 350 AWD with just 58,521 miles. This luxury SUV has been meticulously maintained and recently serviced, in...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA7MC288271
Stock: P8196
Certified Pre-Owned: Yes
Listed since: 07-16-2025 - New Listing$39,995good price$923 below market
- 48,104 miles
- No accidents, 1 owner, personal use only
- 5 Seats, 19 City / 26 Hwy MPG
- Fields Lexus Glenview (302 mi away)
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Located in Glenview, IL / 302 miles away from Des Moines, IA
CARFAX One-Owner. Clean CARFAX. Odometer is 3263 miles below market average!Certified. L/Certified Details: * Warranty Deductible: $0 * CERTIFI...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA2MC263696
Stock: L251387A
Certified Pre-Owned: Yes
Listed since: 09-19-2025 - $41,509fair price$298 above market
- 43,014 miles
- No accidents, 1 owner, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- Lexus of Milwaukee (310 mi away)
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Located in Milwaukee, WI / 310 miles away from Des Moines, IA
Rare Blackline Special Edition!Black grille surround and body side graphic, 20" black wheels, blue stitch interior!Triple-beam led headlamps, corn...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2SZMDA3MC275572
Stock: L21096A
Certified Pre-Owned: Yes
Listed since: 08-21-2025 - $30,886fair price$140 below market
- 90,450 miles
- 1 accident, 3 owners, personal use only
- 5 Seats, 20 City / 27 Hwy MPG
- Jim Norton Toyota of Oklahoma City (469 mi away)
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Located in Oklahoma City, OK / 469 miles away from Des Moines, IA
This 2021 Lexus RX RX 350, has a Atomic Silver exterior and a Black interior. Please call us at 405-443-3142 and reference stock number 27552A for fur...
AutoCheck Vehicle History Summary
Accident Free Vehicle: No
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
23 Combined MPG (20 City/27 Highway)
Listing Information:
VIN: 2T2HZMAA3MC218139
Stock: 27552A
Certified Pre-Owned: No
Listed since: 08-29-2025 - Price Drop$36,999fair price$937 above market
- 42,461 miles
- 1 accident, 1 owner, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- Tom Kadlec Honda (178 mi away)
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Located in Rochester, MN / 178 miles away from Des Moines, IA
Lexus RX 350 3.5L V6 DOHC 24V Carfax 1 owner, AWD, Parchment Artificial Leather, Air Conditioning, AM/FM/CD Radio, Apple CarPlay/Android Auto, Exterio...
AutoCheck Vehicle History Summary
Accident Free Vehicle: No
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA2MC284256
Stock: P12174
Certified Pre-Owned: No
Listed since: 09-16-2025 - 29,661 miles
- No accidents, 1 owner, personal use
- 5 Seats, 20 City / 27 Hwy MPG
- Walser Auto Campus (329 mi away)
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Located in Wichita, KS / 329 miles away from Des Moines, IA
2021 Lexus RX 350, located at Lexus of Wichita. Original MSRP $55,070. Atomic Silver with Black Leather interior. This RX is equipped with the Premium...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
23 Combined MPG (20 City/27 Highway)
Listing Information:
VIN: 2T2HZMAA5MC187802
Stock: 54L1142P
Certified Pre-Owned: No
Listed since: 07-30-2025- 34,502 miles
- No accidents, 1 owner, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- Bergstrom Auto (344 mi away)
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Located in Green Bay, WI / 344 miles away from Des Moines, IA
Recent Arrival! 2021 Lexus RX 350 CARFAX One-Owner. Clean CARFAX. AWD 3.5L V6 DOHC 24V Odometer is 21607 miles below market average! 19/26 City/Highwa...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2JZMDA0MC300486
Stock: 250543A
Certified Pre-Owned: No
Listed since: 08-27-2025- 30,279 miles
- 1 accident, 1 owner, personal use only
- 5 Seats, 19 City / 26 Hwy MPG
- Fields Lexus Glenview (302 mi away)
Close
Located in Glenview, IL / 302 miles away from Des Moines, IA
Just in! This CARFAX one-owner, SUPER LOW MILEAGE, Black / Black RX350 AWD! Perfectly equipped; with premium and cold area packages, power moonroof, A...
AutoCheck Vehicle History Summary
Accident Free Vehicle: No
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA6MC267668
Stock: L251348A
Certified Pre-Owned: Yes
Listed since: 09-05-2025- New Listing$36,990great price$5,095 below market
- 45,947 miles
- No accidents, 1 owner, personal use only
- 5 Seats, 20 City / 27 Hwy MPG
- Carvana - Memphis (491 mi away)
- Home delivery*
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Located in Memphis, TN / 491 miles away from Des Moines, IA
At Carvana, we go miles beyond the extra mile. That's why we provide you with a convenient, fast, and hassle-free car buying experience that puts you ...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
23 Combined MPG (20 City/27 Highway)
Listing Information:
VIN: 2T2HZMAA6NC234207
Stock: 2003996613
Certified Pre-Owned: No
Listed since: 08-27-2025 - $41,495great price$3,867 below market
- 38,964 miles
- No accidents, 1 owner, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- Lexus of Arlington (292 mi away)
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Located in Arlington Heights, IL / 292 miles away from Des Moines, IA
Discover the epitome of luxury and performance in the 2022 Lexus RX 350 Premium. This stunning SUV is a true masterpiece, blending cutting-edge techno...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA8NC316211
Stock: AL4203A
Certified Pre-Owned: Yes
Listed since: 08-30-2025 - Price Drop$37,990great price$3,733 below market
- 47,559 miles
- No accidents, 2 owners, personal use
- 5 Seats, 20 City / 27 Hwy MPG
- Carvana - Indianapolis (410 mi away)
- Home delivery*
Close
Located in Indianapolis, IN / 410 miles away from Des Moines, IA
At Carvana, we go miles beyond the extra mile. That's why we provide you with a convenient, fast, and hassle-free car buying experience that puts you ...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
23 Combined MPG (20 City/27 Highway)
Listing Information:
VIN: 2T2HZMAA0NC223333
Stock: 2004048623
Certified Pre-Owned: No
Listed since: 09-13-2025 - Price Drop$37,197great price$5,115 below market
- 33,486 miles
- 1 accident, 1 owner, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- Ed Martin Toyota (414 mi away)
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Located in Noblesville, IN / 414 miles away from Des Moines, IA
RX 350, 4D Sport Utility, AWD, Parchment Artificial Leather.Heated and Ventilated Front SeatsHeated Leather Steering WheelIntuitive Parking Assist and...
AutoCheck Vehicle History Summary
Accident Free Vehicle: No
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDAXNC355124
Stock: 6P9486
Certified Pre-Owned: No
Listed since: 06-07-2025 - New ListingNot Priced
- 96,849 miles
- 5 Seats, 19 City / 26 Hwy MPG
- Walser Auto Campus (329 mi away)
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Located in Wichita, KS / 329 miles away from Des Moines, IA
AutoCheck Vehicle History Summary Unavailable.
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDAXMC264305
Stock: 54L1368T
Certified Pre-Owned: No
Listed since: 09-22-2025 - $42,999great price$5,496 below market
- 49,720 miles
- 1 accident, 1 owner, personal use only
- 5 Seats, 19 City / 26 Hwy MPG
- Lexus of Wayzata (234 mi away)
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Located in Wayzata, MN / 234 miles away from Des Moines, IA
Lexus Certified Pre-Owned — Exceptional Quality, Unmatched Peace of MindEvery Lexus Certified Pre-Owned vehicle undergoes a comprehensive 161-point i...
AutoCheck Vehicle History Summary
Accident Free Vehicle: No
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2JZMDA7NC348925
Stock: L242060A
Certified Pre-Owned: Yes
Listed since: 09-12-2025 - New Listing$41,995great price$3,937 below market
- 35,939 miles
- No accidents, 1 owner, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- Lexus of Arlington (292 mi away)
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Located in Arlington Heights, IL / 292 miles away from Des Moines, IA
Discover the perfect blend of luxury and capability with this stunning 2022 Lexus RX 350. This meticulously maintained SUV is a true testament to Lexu...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDAXNC362266
Stock: AL4322A
Certified Pre-Owned: Yes
Listed since: 09-18-2025 - 45,224 miles
- Frame damage reported, 2 owners, corporate fleet vehicle
- 5 Seats, 20 City / 27 Hwy MPG
- Baha Auto (305 mi away)
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Located in Chicago, IL / 305 miles away from Des Moines, IA
AutoCheck Vehicle History Summary
Accident Free Vehicle: No
Personal Use Only: No
History Provider: AutoCheck
Title Details: Issue reported
Salvage Vehicle: No
Frame Damage: Yes
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
23 Combined MPG (20 City/27 Highway)
Listing Information:
VIN: 2T2HZMAA1MC215997
Stock: N23059TRTR
Certified Pre-Owned: No- New Listing$40,000great price$3,731 below market
- 43,369 miles
- No accidents, 1 owner, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- Lexus of Milwaukee (310 mi away)
Close
Located in Milwaukee, WI / 310 miles away from Des Moines, IA
Recent Arrival! Certified. CARFAX One-Owner. Black 2022 Lexus RX 4D Sport Utility 350 3.5L V6 DOHC 24V AWD Clean CARFAX.AWD.L/Certified Details:...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA7NC337731
Stock: L21156A
Certified Pre-Owned: Yes
Listed since: 09-19-2025
Showing 1 - 21 out of 1,515 listings
Consumer Reviews for the Lexus RX 350
Read recent reviews for the Lexus RX 350
Always go back to a Lexus
Jim R., 10/28/2020
2021 Lexus RX 350 4dr SUV (3.5L 6cyl 8A)
While I’ve only had the car a week now, first impressions have settled in. First, the RX is a noticeable improvement from my 2018 Volvo XC60. It’s quieter, smoother, and much more comfortable. The features I gained over the Volvo are all little things that appeal to me. For example, the electrically adjustable steering wheel as part of the memory seating position. The fact that the seat … adjusts to my driving position when starting and retracts when stopping are features the Volvo lacked. The Mark Levenson sound system is the best I’ve ever heard in any car. The sometimes maligned trackpad is extremely easy to use, just adding to the excellent user interface overall. I expected the RX to be quiet and it doesn’t disappoint. The ride is so smooth that I deliberately drove over a small section of a local road that is just a mess of badly done patchwork. The Volvo felt like a stagecoach over this small section, the RX is like a pillow top mattress over the same section. The 20” Michelin tires add to the comfort.
My RX included the luxury package, heads up display, heated and cooled seats, triple beam LED headlights, panoramic moonroof and leather upholstery. Overall it is well put together package with more than enough luxury features for what I wanted without the price of the German cars.
This is the fourth Lexus over many years, I always seem to come back the brand.
Used 2021 Lexus RX 350 in Des Moines, IA Values
Estimated values
2021 Lexus RX 350 F SPORT 4dr SUV AWD (3.5L 6cyl 8A) with no options
| Condition | Trade-In | Private Party | Dealer Retail |
|---|---|---|---|
| Outstanding | $32,387 | $34,604 | $36,824 |
| Clean | $31,881 | $34,055 | $36,230 |
| Average | $31,038 | $33,139 | $35,240 |
| Rough | $29,942 | $31,948 | $33,952 |
The average list price of a used 2021 Lexus RX 350 in Des Moines, Iowa is $39,259. The average mileage on a used Lexus RX 350 2021 for sale in Des Moines, Iowa is 44,603. Based on the average mileage of 44,603 for used 2021 Lexus RX 350 for sale in Des Moines, IA and using an average vehicle condition rating, which means the vehicle may have a few mechanical and/or cosmetic problems and may require a considerable amount of reconditioning, we appraise the average trade-in value of a used Lexus RX 350 2021 in Des Moines, Iowa to be $31,038.
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