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1,523 listings
- $35,690good price$1,699 below market
- 80,453 miles
- No accidents, 2 owners, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- McGrath Lexus of Chicago (308 mi away)
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Located in Chicago, IL / 308 miles away from Des Moines, IA
Recent Arrival! Caviar 2022 Lexus RX 350 **APPLE CARPLAY & ANDROID AUTO, **NAVIGATION, **HEATED & COOLED SEATS, **HEATED STEERING WHEEL, **SUNROOF/MOO...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA2NC368000
Stock: S1120B
Certified Pre-Owned: No
Listed since: 06-28-2025 - Price Drop$38,899good price$1,560 below market
- 46,277 miles
- No accidents, 1 owner, personal use only
- 5 Seats, 19 City / 26 Hwy MPG
- Unlimited Motors Noblesville (410 mi away)
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Located in Noblesville, IN / 410 miles away from Des Moines, IA
4x4, AWD, Back Up Camera, Bluetooth, Heated Seats, Navigation/GPS, Sun/Moon Roof, Push Button Start, and much more ..., Touch Screen, RX 350, 4D Sport...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA8NC326978
Stock: STK326978
Certified Pre-Owned: No
Listed since: 08-28-2025 - $37,541fair price$686 below market
- 61,897 miles
- No accidents, 1 owner, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- Biggers Mazda (279 mi away)
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Located in Elgin, IL / 279 miles away from Des Moines, IA
🚗 THE BIGGERS PROMISE! ✔ 100% TRANSPARENT PROCESS! ✔ NO JUNK FEES OR EXTRAS!! ✔ NO LAST-MINUTE PRICE ADD-ONS! ✔ NO SURPRISES — EVER! ✔ NO GAMES, JUST...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA9NC335074
Stock: PMB1020
Certified Pre-Owned: No
Listed since: 07-03-2025 - Price Drop$42,999fair price$246 below market
- 35,754 miles
- No accidents, 1 owner, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- Lexus of Wayzata (234 mi away)
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Located in Wayzata, MN / 234 miles away from Des Moines, IA
Lexus Certified Pre-Owned — Exceptional Quality, Unmatched Peace of MindEvery Lexus Certified Pre-Owned vehicle undergoes a comprehensive 161-point i...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDAXNC342941
Stock: PRS503
Certified Pre-Owned: Yes
Listed since: 08-27-2025 - 13,506 miles
- No accidents, 2 owners, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- Mungenast Lexus of St Louis (266 mi away)
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Located in Manchester, MO / 266 miles away from Des Moines, IA
L/CERTIFIED, Bluetooth Handsfree Link, Backup Camera, Power Sunroof, Intuitive Parking Assist, Blind Spot Monitoring, Lexus Safety System+, Lexus Enfo...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA9NC327850
Stock: P1463
Certified Pre-Owned: Yes
Listed since: 08-08-2025- New Listing$48,908fair price$85 below market
- 19,279 miles
- No accidents, 1 owner, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- Lexus of Orland (300 mi away)
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Located in Orland Park, IL / 300 miles away from Des Moines, IA
Atomic Silver 2022 Lexus RX 350 AWD 8-Speed Automatic 3.5L V6 DOHC 24V NAVIGATION!, LOCAL TRADE!, ONE OWNER!, GREAT VEHICLE HISTORY!, BACK UP CAMERA, ...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA1NC366500
Stock: LX10591
Certified Pre-Owned: Yes
Listed since: 09-19-2025 - $32,988fair price$424 below market
- 64,853 miles
- No accidents, 2 owners, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- Perillo BMW (310 mi away)
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Located in Chicago, IL / 310 miles away from Des Moines, IA
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA4LC227099
Stock: B48058B
Certified Pre-Owned: No
Listed since: 09-10-2025 - $40,994fair price$444 below market
- 50,807 miles
- No accidents, 1 owner, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- Napleton Hyundai of Carmel (410 mi away)
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Located in Indianapolis, IN / 410 miles away from Des Moines, IA
Recent Arrival! CARFAX One-Owner. Gray 2022 Lexus RX 4D Sport Utility 350 F Sport 3.5L V6 DOHC 24V AWD 8-Speed Automatic Clean CARFAX.AWD, Red Artific...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2SZMDA3NC309480
Stock: HRS5945
Certified Pre-Owned: No
Listed since: 09-17-2025 - New Listing$30,990fair price$90 below market
- 74,528 miles
- No accidents, 2 owners, personal use only
- 5 Seats, 20 City / 27 Hwy MPG
- Carvana - Memphis (491 mi away)
- Home delivery*
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Located in Memphis, TN / 491 miles away from Des Moines, IA
At Carvana, we go miles beyond the extra mile. That's why we provide you with a convenient, fast, and hassle-free car buying experience that puts you ...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
23 Combined MPG (20 City/27 Highway)
Listing Information:
VIN: 2T2HZMAA5LC153275
Stock: 2004070436
Certified Pre-Owned: No
Listed since: 09-13-2025 - New Listing$37,200good price$1,953 below market
- 70,112 miles
- No accidents, 1 owner, personal use only
- 5 Seats, 19 City / 26 Hwy MPG
- Lexus of Milwaukee (310 mi away)
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Located in Milwaukee, WI / 310 miles away from Des Moines, IA
L/Certified Details: * Vehicle History * Limited Warranty: 24 Month/Unlimited Mile * Roadside Assistance * 161 Point Inspection * CERTIFIED...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2SZMDA5NC315751
Stock: L21189A
Certified Pre-Owned: Yes
Listed since: 09-19-2025 - New Listing$42,291good price$1,909 below market
- 39,133 miles
- No accidents, 1 owner, personal use only
- 5 Seats, 19 City / 26 Hwy MPG
- Ed Martin Toyota (414 mi away)
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Located in Noblesville, IN / 414 miles away from Des Moines, IA
RX 350 F Sport, 4D Sport Utility, 3.5L V6 DOHC 24V, 8-Speed Automatic, AWD, Ultra White, Circuit Red Artificial Leather.19/26 City/Highway MPGWireless...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2SZMDA7NC315833
Stock: 621404A
Certified Pre-Owned: No
Listed since: 09-19-2025 - $42,990fair price$733 below market
- 22,033 miles
- 1 accident, 1 owner, corporate fleet vehicle
- 5 Seats, 20 City / 27 Hwy MPG
- Unlimited Motors Westfield (404 mi away)
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Located in Westfield, IN / 404 miles away from Des Moines, IA
Back Up Camera, Bluetooth, Sun/Moon Roof, Heated Seats, Touch Screen, Cooled Heats, Blind Spot, Heated Steering Wheel, RX 350, 4D Sport Utility, 3.5L ...
AutoCheck Vehicle History Summary
Accident Free Vehicle: No
Personal Use Only: No
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
23 Combined MPG (20 City/27 Highway)
Listing Information:
VIN: 2T2HZMAA4NC233248
Stock: STK233248
Certified Pre-Owned: No
Listed since: 08-29-2025 - $49,995fair price$1,153 above market
- 31,696 miles
- No accidents, 2 owners, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- Woodfield Lexus (288 mi away)
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Located in Schaumburg, IL / 288 miles away from Des Moines, IA
**ADDITIONAL 2 YEARS/UNLIMITED MILE COMPREHENSIVE WARRANTY AND COMPLIMENTARY MAINTENANCE**, **Lexus Safety System Plus**, ** Lane Departure Warning, *...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2YZMDA1NC367680
Stock: Q3689
Certified Pre-Owned: Yes
Listed since: 09-09-2025 - $43,887fair price$178 above market
- 36,836 miles
- No accidents, 1 owner, corporate fleet vehicle
- 5 Seats, 19 City / 26 Hwy MPG
- Serra Chevrolet (487 mi away)
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Located in Bartlett, TN / 487 miles away from Des Moines, IA
AWD. CARFAX One-Owner.AWD, 20 x 8 Aluminum Wheels, 3.33 Axle Ratio, 4-Wheel Disc Brakes, 9 Speakers, ABS brakes, Air Conditioning, Alloy wheels, AM/FM...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: No
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2SZMDA6NC337709
Stock: PNC337709
Certified Pre-Owned: No
Listed since: 07-30-2025 - $43,990fair price$128 above market
- 26,131 miles
- No accidents, 1 owner, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- Unlimited Motors Westfield (404 mi away)
Close
Located in Westfield, IN / 404 miles away from Des Moines, IA
Back Up Camera, Bluetooth, Sun/Moon Roof, Heated Seats, Touch Screen, Cooled Heats, Blind Spot, Heated Steering Wheel, RX 350 F Sport, 4D Sport Utilit...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2SZMDA6NC331683
Stock: STK331683
Certified Pre-Owned: No
Listed since: 08-22-2025 - Price Drop$41,999fair price$1,074 above market
- 30,788 miles
- No accidents, 1 owner, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- Tom Kadlec Honda (178 mi away)
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Located in Rochester, MN / 178 miles away from Des Moines, IA
Lexus RX 350 3.5L V6 DOHC 24V Carfax 1 owner, AWD, Parchment Artificial Leather, Air Conditioning, AM/FM/CD Radio, Apple CarPlay/Android Auto, Automat...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA3NC344353
Stock: P12157
Certified Pre-Owned: No
Listed since: 09-11-2025 - Price Drop$45,499fair price$516 above market
- 28,365 miles
- No accidents, 1 owner, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- Lexus of Wayzata (234 mi away)
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Located in Wayzata, MN / 234 miles away from Des Moines, IA
Recent Arrival! CARFAX One-Owner. Certified. Caviar 2022 Lexus RX 4D Sport Utility 350 3.5L V6 DOHC 24V AWD 19/26 City/Highway MPG Odometer is 4365 mi...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA9NC320638
Stock: PRS507
Certified Pre-Owned: Yes
Listed since: 09-09-2025 - Price Drop$33,950fair price$348 above market
- 56,167 miles
- No accidents, 1 owner, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- Carmel Auto Gallery (408 mi away)
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Located in Carmel, IN / 408 miles away from Des Moines, IA
Clean CARFAX. Nebula Gray Pearl 2020 Lexus RX 350 AWD 8-Speed Automatic 3.5L V6 DOHC 24V Android Auto, CarPlay, SunRoof/Moonroof, Power Drivers Seat,...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA3LC235789
Stock: V35789
Certified Pre-Owned: No
Listed since: 07-31-2025 - $41,984fair price$920 above market
- 29,376 miles
- No accidents, 1 owner, personal use
- 5 Seats, 20 City / 27 Hwy MPG
- Tom Wood Volkswagen Noblesville (414 mi away)
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Located in Noblesville, IN / 414 miles away from Des Moines, IA
*** SOPHISTICATED LUXURY & STRONG PERFORMANCE IN A MIDSIZE SUV! ***2022 Lexus RX 350 9 Speakers, Apple CarPlay/Android Auto, Compass, Emergency comm...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
23 Combined MPG (20 City/27 Highway)
Listing Information:
VIN: 2T2HZMAA9NC228594
Stock: VNI228594
Certified Pre-Owned: No
Listed since: 08-20-2025 - New Listing$43,500good price$2,173 below market
- 43,666 miles
- 5 Seats, 19 City / 26 Hwy MPG
- Reliable Superstore (305 mi away)
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Located in Springfield, MO / 305 miles away from Des Moines, IA
Recent Arrival! Odometer is 2352 miles below market average! CARFAX One-Owner. Clean CARFAX. 2022 Lexus RX 350 F Sport Nightfall Mica 4D Sport Utility...
AutoCheck Vehicle History Summary Unavailable.
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2SZMDA2NC360940
Stock: NC360940P
Certified Pre-Owned: No
Listed since: 09-22-2025 - $49,988fair price$1,041 below market
- 12,432 miles
- 1 accident, 1 owner, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- McGrath Lexus of Chicago (308 mi away)
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Located in Chicago, IL / 308 miles away from Des Moines, IA
Recent Arrival! Caviar 2022 Lexus RX 350 F Sport **L/CERTIFIED BY LEXUS, **2 YRS & UNLIMITED MILE WARRANTY W/ YOUR NEXT 4 RECOMMENDED SERVICES, **APPL...
AutoCheck Vehicle History Summary
Accident Free Vehicle: No
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2SZMDA4NC368330
Stock: S1777A
Certified Pre-Owned: Yes
Listed since: 09-08-2025
Showing 43 - 63 out of 1,523 listings
Consumer Reviews for the Lexus RX 350
Read recent reviews for the Lexus RX 350
Always go back to a Lexus
Jim R., 10/28/2020
2021 Lexus RX 350 4dr SUV (3.5L 6cyl 8A)
While I’ve only had the car a week now, first impressions have settled in. First, the RX is a noticeable improvement from my 2018 Volvo XC60. It’s quieter, smoother, and much more comfortable. The features I gained over the Volvo are all little things that appeal to me. For example, the electrically adjustable steering wheel as part of the memory seating position. The fact that the seat … adjusts to my driving position when starting and retracts when stopping are features the Volvo lacked. The Mark Levenson sound system is the best I’ve ever heard in any car. The sometimes maligned trackpad is extremely easy to use, just adding to the excellent user interface overall. I expected the RX to be quiet and it doesn’t disappoint. The ride is so smooth that I deliberately drove over a small section of a local road that is just a mess of badly done patchwork. The Volvo felt like a stagecoach over this small section, the RX is like a pillow top mattress over the same section. The 20” Michelin tires add to the comfort.
My RX included the luxury package, heads up display, heated and cooled seats, triple beam LED headlights, panoramic moonroof and leather upholstery. Overall it is well put together package with more than enough luxury features for what I wanted without the price of the German cars.
This is the fourth Lexus over many years, I always seem to come back the brand.
Used 2022 Lexus RX 350 in Des Moines, IA Values
Estimated values
2022 Lexus RX 350 4dr SUV AWD (3.5L 6cyl 8A) with no options
| Condition | Trade-In | Private Party | Dealer Retail |
|---|---|---|---|
| Outstanding | $33,127 | $35,240 | $37,443 |
| Clean | $32,686 | $34,752 | $36,904 |
| Average | $31,950 | $33,938 | $36,007 |
| Rough | $30,994 | $32,881 | $34,841 |
The average list price of a used 2022 Lexus RX 350 in Des Moines, Iowa is $41,648. The average mileage on a used Lexus RX 350 2022 for sale in Des Moines, Iowa is 41,623. Based on the average mileage of 41,623 for used 2022 Lexus RX 350 for sale in Des Moines, IA and using an average vehicle condition rating, which means the vehicle may have a few mechanical and/or cosmetic problems and may require a considerable amount of reconditioning, we appraise the average trade-in value of a used Lexus RX 350 2022 in Des Moines, Iowa to be $31,950.
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