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1,523 listings
- 30,165 miles
- No accidents, 1 owner, personal use only
- 5 Seats, 19 City / 26 Hwy MPG
- Jack Schmitt Chevrolet of O'Fallon (285 mi away)
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Located in O Fallon, IL / 285 miles away from Des Moines, IA
Clean CARFAX. Odometer is 5448 miles below market average! This 2022 Lexus RX comes equipped with the following - AWD, 18' x 8' Aluminum Wheels, 3.33 ...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA1NC351611
Stock: 16386P
Certified Pre-Owned: No
Listed since: 08-07-2025- Price Drop$42,999fair price$654 above market
- 41,919 miles
- No accidents, 1 owner, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- Lexus of Wayzata (234 mi away)
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Located in Wayzata, MN / 234 miles away from Des Moines, IA
Lexus Certified Pre-Owned — Exceptional Quality, Unmatched Peace of MindEvery Lexus Certified Pre-Owned vehicle undergoes a comprehensive 161-point i...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA0NC347436
Stock: PRS505
Certified Pre-Owned: Yes
Listed since: 08-29-2025 - $37,000fair price$484 above market
- 39,727 miles
- No accidents, 1 owner, personal use only
- 5 Seats, 19 City / 26 Hwy MPG
- Lakeside Automotive Group (395 mi away)
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Located in Spring Lake, MI / 395 miles away from Des Moines, IA
2020 Lexus RX 350 Black CARFAX One-Owner. Odometer is 12353 miles below market average! ***CLEAN CARFAX***, ***ONE OWNER***, RX 350, 3.5L V6 DOHC 24V,...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2JZMDA6LC239403
Stock: 8269
Certified Pre-Owned: No
Listed since: 04-11-2025 - $36,857fair price$133 above market
- 60,675 miles
- No accidents, 1 owner, personal use only
- 5 Seats, 19 City / 26 Hwy MPG
- Carlson Toyota (250 mi away)
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Located in Coon Rapids, MN / 250 miles away from Des Moines, IA
Introducing the 2022 Lexus RX 350, a luxurious and sophisticated SUV that embodies elegance, performance, and cutting-edge technology. This exceptiona...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA8NC337057
Stock: P11810
Certified Pre-Owned: No
Listed since: 07-15-2025 - $41,988fair price$64 below market
- 50,506 miles
- No accidents, 1 owner, personal use only
- 5 Seats, 19 City / 26 Hwy MPG
- McGrath Lexus of Chicago (308 mi away)
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Located in Chicago, IL / 308 miles away from Des Moines, IA
Recent Arrival! Nightfall Mica 2022 Lexus RX 350 **L/CERTIFIED BY LEXUS, **2 YRS & UNLIMITED MILE WARRANTY W/ YOUR NEXT 4 RECOMMENDED SERVICES, **APPL...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA8NC356143
Stock: S1615A
Certified Pre-Owned: Yes
Listed since: 08-18-2025 - New Listing$40,998fair price$1,178 above market
- 45,640 miles
- No accidents, 1 owner, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- CarMax Hillside (Eisenhower Expy) (296 mi away)
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Located in Hillside, IL / 296 miles away from Des Moines, IA
CarMax values transparency and wants you to love your next car, not settle on it. Certain vehicles may have unrepaired safety recalls. Check nhtsa.gov...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA4NC318912
Stock: 27628054
Certified Pre-Owned: No - Price Drop$29,555fair price$43 above market
- 120,500 miles
- No accidents, 1 owner, personal use only
- 5 Seats, 19 City / 26 Hwy MPG
- BMW of Louisville (488 mi away)
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Located in Louisville, KY / 488 miles away from Des Moines, IA
2022 Lexus RX 350 F Sport Caviar CARFAX One-Owner. Clean CARFAX.AWD, Black Artificial Leather. 19/26 City/Highway MPGBMW of Louisville is Louisville's...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2SZMDA3NC351566
Stock: P351566
Certified Pre-Owned: No
Listed since: 07-15-2025 - Price Drop$36,555fair price$654 above market
- 42,005 miles
- No accidents, 1 owner, personal use only
- 5 Seats, 19 City / 26 Hwy MPG
- BMW of Louisville (488 mi away)
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Located in Louisville, KY / 488 miles away from Des Moines, IA
2020 Lexus RX 350 Nebula Gray Pearl Recent Arrival! Odometer is 11244 miles below market average! CARFAX One-Owner. Clean CARFAX.AWD, Birch w/NuLuxe S...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA3LC255265
Stock: 9184517A
Certified Pre-Owned: No
Listed since: 09-11-2025 - Price Drop$36,431fair price$1,044 above market
- 53,101 miles
- No accidents, 1 owner, personal use only
- 5 Seats, 19 City / 26 Hwy MPG
- Genesis of Conway (454 mi away)
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Located in Conway, AR / 454 miles away from Des Moines, IA
New Price! Recent Arrival!RX 350, 4D Sport Utility, 3.5L V6 DOHC 24V, 8-Speed Automatic, AWD, Nightfall Mica, Parchment w/NuLuxe Seat Trim, 12.3" Navi...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA0LC232199
Stock: 6GC2107H
Certified Pre-Owned: No
Listed since: 09-09-2025 - Price Drop$40,301fair price$244 above market
- 60,898 miles
- No accidents, 1 owner, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- Burnsville Toyota (218 mi away)
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Located in Burnsville, MN / 218 miles away from Des Moines, IA
NAVIGATION SYSTEM*, *AWD*, *CRUISE CONTROL*, *HARD TO FIND*, *HEATED FRONT SEATS*, LEATHER SEATS*, MOONROOF*, ALLOY WHEELS*, BLUETOOTH*, 3.5L V6 DOHC ...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA8NC342985
Stock: 1036761
Certified Pre-Owned: No
Listed since: 08-20-2025 - Price Drop
- 53,935 miles
- No accidents, 1 owner, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- Burnsville Toyota (218 mi away)
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Located in Burnsville, MN / 218 miles away from Des Moines, IA
*CRUISE CONTROL*, *HEATED FRONT SEATS*, LEATHER SEATS*, BACKUP CAMERA*, MOONROOF*, ALLOY WHEELS*, BLUETOOTH*, RX 350, AWD. CARFAX One-Owner.2022 Lex...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA5NC344399
Stock: 1036675
Certified Pre-Owned: No
Listed since: 08-05-2025 - $39,992fair price$1,029 above market
- 69,576 miles
- No accidents, 1 owner, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- Lexus of Brookfield (297 mi away)
- Five Star Dealer
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Located in Brookfield, WI / 297 miles away from Des Moines, IA
**L/Certified** Clean CARFAX. CARFAX One-Owner. Certified. Caviar 2022 Lexus RX 350 8-Speed Automatic AWDPanorama Moonroof!Heated and Ventilated S...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA6NC337381
Stock: PWS2809
Certified Pre-Owned: Yes
Listed since: 09-03-2025 - New Listing$35,590fair price$550 above market
- 33,933 miles
- 1 accident, 1 owner, personal use only
- 5 Seats, 19 City / 26 Hwy MPG
- Carvana - Indianapolis (410 mi away)
- Home delivery*
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Located in Indianapolis, IN / 410 miles away from Des Moines, IA
At Carvana, we go miles beyond the extra mile. That's why we provide you with a convenient, fast, and hassle-free car buying experience that puts you ...
AutoCheck Vehicle History Summary
Accident Free Vehicle: No
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA4LC232772
Stock: 2003944553
Certified Pre-Owned: No
Listed since: 07-30-2025 - Price Drop
- 27,267 miles
- No accidents, 1 owner, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- Burnsville Toyota (218 mi away)
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Located in Burnsville, MN / 218 miles away from Des Moines, IA
*CLEAN 1-OWNER CARFAX*, *CRUISE CONTROL*, *HEATED FRONT SEATS*, LEATHER SEATS*, BACKUP CAMERA*, MOONROOF*, ALLOY WHEELS*, BLUETOOTH*, RX 350, AWD. Cle...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA3NC363159
Stock: 1036705
Certified Pre-Owned: No
Listed since: 08-15-2025 - Price Drop
- 63,755 miles
- No accidents, 2 owners, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- Lexus of Brookfield (297 mi away)
- Five Star Dealer
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Located in Brookfield, WI / 297 miles away from Des Moines, IA
**L/Certified** Clean CARFAX. Caviar 2022 Lexus RX 350 F Sport Handling 8-Speed Automatic AWDCold Weather Package!Mark Levinson Premium Sound!12...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2YZMDA4NC309126
Stock: PWS2760A
Certified Pre-Owned: Yes
Listed since: 08-15-2025 - Price Drop
- 27,673 miles
- No accidents, 1 owner, personal use only
- 5 Seats, 19 City / 26 Hwy MPG
- Lexus of Orland (300 mi away)
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Located in Orland Park, IL / 300 miles away from Des Moines, IA
Eminent White Pearl 2022 Lexus RX 350 AWD 8-Speed Automatic 3.5L V6 DOHC 24V NAVIGATION!, BOUGHT HERE SERVICED HERE!, LOCAL TRADE!, ONE OWNER!, GREAT ...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA3NC318366
Stock: PB7884
Certified Pre-Owned: Yes
Listed since: 09-17-2025 - New Listing$41,887fair price$1,325 above market
- 44,988 miles
- 1 accident, 1 owner, personal use only
- 5 Seats, 19 City / 26 Hwy MPG
- Bergstrom Auto (344 mi away)
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Located in Green Bay, WI / 344 miles away from Des Moines, IA
* Heated Seats * Keyless Entry * Apple Carplay/Android Auto * Power Liftgate * Rear Backup Camera * Lexus Certified Certified. L/Certified Details: * ...
AutoCheck Vehicle History Summary
Accident Free Vehicle: No
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA9NC334880
Stock: 250547A
Certified Pre-Owned: No
Listed since: 08-30-2025 - Price Drop$40,990fair price$723 above market
- 42,928 miles
- 1 accident, 1 owner, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- Unlimited Motors Noblesville (410 mi away)
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Located in Noblesville, IN / 410 miles away from Des Moines, IA
4x4, AWD, Back Up Camera, Bluetooth, Heated Seats, Sun/Moon Roof, Push Button Start, and much more ..., Touch Screen, RX 350 F Sport, 4D Sport Utility...
AutoCheck Vehicle History Summary
Accident Free Vehicle: No
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2SZMDAXNC355503
Stock: STK355503
Certified Pre-Owned: No
Listed since: 08-22-2025 - $35,500fair price$1,106 above market
- 51,717 miles
- 1 accident, 2 owners, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- Unlimited Motors Noblesville (410 mi away)
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Located in Noblesville, IN / 410 miles away from Des Moines, IA
4x4, AWD, Back Up Camera, Bluetooth, Heated Seats, Navigation/GPS, Sun/Moon Roof, Push Button Start, and much more ..., Touch Screen, RX 350, 4D Sport...
AutoCheck Vehicle History Summary
Accident Free Vehicle: No
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA9LC214414
Stock: STK214414
Certified Pre-Owned: No
Listed since: 09-08-2025 - New Listing
- 23,948 miles
- No accidents, 1 owner, personal use only
- 5 Seats, 19 City / 26 Hwy MPG
- CarMax Waukesha (296 mi away)
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Located in Waukesha, WI / 296 miles away from Des Moines, IA
CarMax values transparency and wants you to love your next car, not settle on it. Certain vehicles may have unrepaired safety recalls. Check nhtsa.gov...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: Yes
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2SZMDA0NC332456
Stock: 27346918
Certified Pre-Owned: No - 26,002 miles
- No accidents, 1 owner, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- Ray Skillman Mazda West (405 mi away)
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Located in Indianapolis, IN / 405 miles away from Des Moines, IA
Silver 2022 Lexus RX 350 F Sport Handling
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2YZMDAXNC354006
Stock: JJ2444
Certified Pre-Owned: No
Listed since: 06-05-2025
Showing 64 - 84 out of 1,523 listings
Consumer Reviews for the Lexus RX 350
Read recent reviews for the Lexus RX 350
Always go back to a Lexus
Jim R., 10/28/2020
2021 Lexus RX 350 4dr SUV (3.5L 6cyl 8A)
While I’ve only had the car a week now, first impressions have settled in. First, the RX is a noticeable improvement from my 2018 Volvo XC60. It’s quieter, smoother, and much more comfortable. The features I gained over the Volvo are all little things that appeal to me. For example, the electrically adjustable steering wheel as part of the memory seating position. The fact that the seat … adjusts to my driving position when starting and retracts when stopping are features the Volvo lacked. The Mark Levenson sound system is the best I’ve ever heard in any car. The sometimes maligned trackpad is extremely easy to use, just adding to the excellent user interface overall. I expected the RX to be quiet and it doesn’t disappoint. The ride is so smooth that I deliberately drove over a small section of a local road that is just a mess of badly done patchwork. The Volvo felt like a stagecoach over this small section, the RX is like a pillow top mattress over the same section. The 20” Michelin tires add to the comfort.
My RX included the luxury package, heads up display, heated and cooled seats, triple beam LED headlights, panoramic moonroof and leather upholstery. Overall it is well put together package with more than enough luxury features for what I wanted without the price of the German cars.
This is the fourth Lexus over many years, I always seem to come back the brand.
Used 2022 Lexus RX 350 in Des Moines, IA Values
Estimated values
2022 Lexus RX 350 4dr SUV AWD (3.5L 6cyl 8A) with no options
| Condition | Trade-In | Private Party | Dealer Retail |
|---|---|---|---|
| Outstanding | $32,435 | $34,504 | $36,660 |
| Clean | $32,003 | $34,026 | $36,133 |
| Average | $31,282 | $33,229 | $35,254 |
| Rough | $30,346 | $32,194 | $34,112 |
The average list price of a used 2022 Lexus RX 350 in Des Moines, Iowa is $40,833. The average mileage on a used Lexus RX 350 2022 for sale in Des Moines, Iowa is 48,136. Based on the average mileage of 48,136 for used 2022 Lexus RX 350 for sale in Des Moines, IA and using an average vehicle condition rating, which means the vehicle may have a few mechanical and/or cosmetic problems and may require a considerable amount of reconditioning, we appraise the average trade-in value of a used Lexus RX 350 2022 in Des Moines, Iowa to be $31,282.
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