I have never had any significant problems with either of my 300's. Put lots of miles on them (168,000 first one) (138,000 second - so far). It really helps to have a good dealer. I have a really good one in the small town where I live. I see many comments about bad repair issues. The consistency of Chrysler dealers is an issue.
This is my 5th Chrysler 300 and it is the best yet. Drive 75 to 80 mph and get 28/29 mpg. Only time in the shop is for oil changes and tire rotation of tires. No warranty claims. Best value of equipment. Would buy another without looking at any other vehicle.
The classic American luxo-cruiser sedan survives, the 300 Hemi pays tribute to it forerunners of the 60's with great respect for tradition. I have owned several 300's and Chargers, they are just great cars. Driving comfort, great style and power o'plenty are this car's greatest attributes. The C&D and Edmunds reviewers always complain about body roll and other handling characteristics that the vast majority of drivers, including enthusiasts couldn't distinguish from dog doodle--people that buy this car do so for it's all too uncommon style and comfort--not to put it on the track at Road America. The 300 is a great ride for your daily driver, even with the Hemi it gives respectable fuel economy. A skilled driver can squeeze 20-21 mpg for a typical mix of city and highway driving. I hope the next generation is even better.