Skip to FiltersReport abuse
1,545 listings
- $36,990great price$4,413 below market
- 45,947 miles
- No accidents, 1 owner, personal use only
- 5 Seats, 20 City / 27 Hwy MPG
- Carvana - Oklahoma City (472 mi away)
- Home delivery*
Close
Located in Oklahoma City, OK / 472 miles away from Des Moines, IA
At Carvana, we go miles beyond the extra mile. That's why we provide you with a convenient, fast, and hassle-free car buying experience that puts you ...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
23 Combined MPG (20 City/27 Highway)
Listing Information:
VIN: 2T2HZMAA6NC234207
Stock: 2003996613
Certified Pre-Owned: No
Listed since: 08-27-2025 - $41,495great price$3,913 below market
- 38,964 miles
- No accidents, 1 owner, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- Lexus of Arlington (292 mi away)
Close
Located in Arlington Heights, IL / 292 miles away from Des Moines, IA
Discover the epitome of luxury and performance in the 2022 Lexus RX 350 Premium. This stunning SUV is a true masterpiece, blending cutting-edge techno...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA8NC316211
Stock: AL4203A
Certified Pre-Owned: Yes
Listed since: 08-30-2025 - Price Drop$37,197great price$5,149 below market
- 33,486 miles
- 1 accident, 1 owner, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- Ed Martin Toyota (414 mi away)
Close
Located in Noblesville, IN / 414 miles away from Des Moines, IA
RX 350, 4D Sport Utility, AWD, Parchment Artificial Leather.Heated and Ventilated Front SeatsHeated Leather Steering WheelIntuitive Parking Assist and...
AutoCheck Vehicle History Summary
Accident Free Vehicle: No
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDAXNC355124
Stock: 6P9486
Certified Pre-Owned: No
Listed since: 06-07-2025 - $42,999great price$5,597 below market
- 49,720 miles
- 1 accident, 1 owner, personal use only
- 5 Seats, 19 City / 26 Hwy MPG
- Lexus of Wayzata (234 mi away)
Close
Located in Wayzata, MN / 234 miles away from Des Moines, IA
Lexus Certified Pre-Owned — Exceptional Quality, Unmatched Peace of MindEvery Lexus Certified Pre-Owned vehicle undergoes a comprehensive 161-point i...
AutoCheck Vehicle History Summary
Accident Free Vehicle: No
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2JZMDA7NC348925
Stock: L242060A
Certified Pre-Owned: Yes
Listed since: 09-12-2025 - New Listing$40,000great price$3,935 below market
- 43,369 miles
- No accidents, 1 owner, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- Lexus of Milwaukee (310 mi away)
Close
Located in Milwaukee, WI / 310 miles away from Des Moines, IA
Recent Arrival! Certified. CARFAX One-Owner. Black 2022 Lexus RX 4D Sport Utility 350 3.5L V6 DOHC 24V AWD Clean CARFAX.AWD.L/Certified Details:...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA7NC337731
Stock: L21156A
Certified Pre-Owned: Yes
Listed since: 09-19-2025 - Price Drop$43,499good price$2,396 below market
- 31,062 miles
- No accidents, 1 owner, personal use only
- 5 Seats, 19 City / 26 Hwy MPG
- Lexus of Maplewood (240 mi away)
Close
Located in Maplewood, MN / 240 miles away from Des Moines, IA
L/Certified by Lexus, CarFax One Owner and No Accidents, AWD, Apple CarPlay, Android Auto, Heated and Ventilated Front and Rear Seats, Heated Steering...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA9NC322731
Stock: PRH19502
Certified Pre-Owned: Yes
Listed since: 08-11-2025 - $45,499good price$3,296 below market
- 29,573 miles
- No accidents, 1 owner, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- Lexus of Maplewood (240 mi away)
Close
Located in Maplewood, MN / 240 miles away from Des Moines, IA
Recent Arrival! Certified. CARFAX One-Owner. Atomic Silver 2022 Lexus RX 4D Sport Utility 350 3.5L V6 DOHC 24V AWD Odometer is 10581 miles below marke...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA9NC363084
Stock: L311216A
Certified Pre-Owned: Yes
Listed since: 09-15-2025 - $47,500good price$2,404 below market
- 4,845 miles
- No accidents, 1 owner, personal use only
- 5 Seats, 19 City / 26 Hwy MPG
- Corwin Chrysler Dodge Jeep RAM FIAT of Springfield (301 mi away)
Close
Located in Springfield, MO / 301 miles away from Des Moines, IA
Recent Arrival! Corwin Chrysler Dodge Jeep Ram Fiat is pleased to offer this. Lexus RX that is well equipped and includes these key features and benef...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA3NC321106
Stock: 3321106
Certified Pre-Owned: No
Listed since: 09-11-2025 - Price Drop$37,990good price$3,501 below market
- 47,559 miles
- No accidents, 2 owners, personal use
- 5 Seats, 20 City / 27 Hwy MPG
- Carvana - Indianapolis (410 mi away)
- Home delivery*
Close
Located in Indianapolis, IN / 410 miles away from Des Moines, IA
At Carvana, we go miles beyond the extra mile. That's why we provide you with a convenient, fast, and hassle-free car buying experience that puts you ...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
23 Combined MPG (20 City/27 Highway)
Listing Information:
VIN: 2T2HZMAA0NC223333
Stock: 2004048623
Certified Pre-Owned: No
Listed since: 09-13-2025 - $44,495good price$2,742 below market
- 13,839 miles
- No accidents, 2 owners, corporate fleet vehicle
- 5 Seats, 19 City / 26 Hwy MPG
- Inver Grove Toyota (229 mi away)
Close
Located in Inver Grove Heights, MN / 229 miles away from Des Moines, IA
Caviar 2022 Lexus RX 350 AWD 8-Speed Automatic 3.5L V6 DOHC 24VRecent Arrival! 19/26 City/Highway MPG
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: No
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2AZMDA7NC320414
Stock: A14661A
Certified Pre-Owned: No
Listed since: 07-02-2025 - Price Drop$39,658good price$2,566 below market
- 41,648 miles
- No accidents, 2 owners, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- Mercedes-Benz of Westmont (292 mi away)
Close
Located in Westmont, IL / 292 miles away from Des Moines, IA
12.3" Navigation SystemIntuitive Parking Assist W/Panoramic View MonitorTilt & Slide MoonroofHeated & Ventilated Front SeatsColor Heads-Up Display...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2SZMDA5NC362245
Stock: NC362245
Certified Pre-Owned: No
Listed since: 08-14-2025 - $38,697good price$2,209 below market
- 35,606 miles
- No accidents, 1 owner, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- EchoPark Automotive St. Louis (255 mi away)
Close
Located in Chestefield, MO / 255 miles away from Des Moines, IA
At EchoPark, it’s all about offering you options for a happy experience. We have thousands of new-to-you makes and models that range from sedans to tr...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA6NC359025
Stock: PNC359025
Certified Pre-Owned: No
Listed since: 07-17-2025 - Price Drop$43,999good price$2,576 below market
- 36,486 miles
- No accidents, 1 owner, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- Lexus of Maplewood (240 mi away)
Close
Located in Maplewood, MN / 240 miles away from Des Moines, IA
L/Certified by Lexus, Carfax One Owner and No Accidents, AWD, Apple CarPlay, Android Auto, Heated and Ventilated Front Seats, Heated Steering Wheel, P...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA6NC363009
Stock: PRH19511
Certified Pre-Owned: Yes
Listed since: 09-03-2025 - $38,908good price$2,653 below market
- 42,833 miles
- No accidents, 1 owner, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- Toyota of Brookfield (297 mi away)
Close
Located in Brookfield, WI / 297 miles away from Des Moines, IA
CARFAX One-Owner. Clean CARFAX. Eminent White Pearl 2022 Lexus RX 350 AWD 8-Speed Automatic 3.5L V6 DOHC 24V AWD, Parchment w/NuLuxe Seat Trim, Cold A...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA1NC359448
Stock: P84234
Certified Pre-Owned: No
Listed since: 08-23-2025 - Price Drop$35,827fair price$952 above market
- 62,628 miles
- No accidents, 1 owner, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- Stew Hansen Buick GMC (6 mi away)
Close
Located in Clive, IA / 6 miles away from Des Moines, IA
2022 Lexus RX 350 AWD - CarBravo Certified Luxury & All-Weather Capability!Experience elegance, power, and peace of mind with this 2022 Lexus RX 350 A...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2AZMDA6NC312059
Stock: 31721
Certified Pre-Owned: No
Listed since: 08-07-2025 - $38,474good price$2,672 below market
- 26,116 miles
- 1 accident, 2 owners, personal use only
- 5 Seats, 20 City / 27 Hwy MPG
- The Internet Car Lot (127 mi away)
Close
Located in Omaha, NE / 127 miles away from Des Moines, IA
Experience luxury and reliability with this 2022 Lexus RX 350 FWD, powered by a smooth 3.5L V6 engine delivering an efficient 20 city / 27 highway MPG...
AutoCheck Vehicle History Summary
Accident Free Vehicle: No
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
23 Combined MPG (20 City/27 Highway)
Listing Information:
VIN: 2T2HZMAA8NC250358
Stock: 250358C71384
Certified Pre-Owned: No - $38,995fair price$783 below market
- 76,989 miles
- No accidents, 1 owner, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- Fields Lexus Glenview (302 mi away)
Close
Located in Glenview, IL / 302 miles away from Des Moines, IA
Recently received and ready for immediate delivery is this one-owner, clean CARFAX, GORGEOUS, PERFECTLY MAINTAINED, Atomic Silver / Black RX350 AWD! M...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA1NC312596
Stock: L251016A
Certified Pre-Owned: Yes
Listed since: 07-31-2025 - New Listing$43,590fair price$1,205 below market
- 20,871 miles
- No accidents, 1 owner, personal use
- 5 Seats, 20 City / 27 Hwy MPG
- Carvana - Oklahoma City (472 mi away)
- Home delivery*
Close
Located in Oklahoma City, OK / 472 miles away from Des Moines, IA
At Carvana, we go miles beyond the extra mile. That's why we provide you with a convenient, fast, and hassle-free car buying experience that puts you ...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
23 Combined MPG (20 City/27 Highway)
Listing Information:
VIN: 2T2HZMAA7NC250920
Stock: 2003575564
Certified Pre-Owned: No
Listed since: 09-17-2025 - Price Drop$44,243fair price$16 below market
- 22,159 miles
- No accidents, 1 owner, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- McGrath Acura of Westmont (293 mi away)
Close
Located in Westmont, IL / 293 miles away from Des Moines, IA
Silver 2022 Lexus RX 350 F Sport AWD 8-Speed Automatic 3.5L V6 DOHC 24V. $4035 IN ADDED OPTIONS! **ONE OWNER**, **ACCIDENT FREE CARFAX**, **AWD**, *N...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2SZMDA5NC339886
Stock: PJ12450
Certified Pre-Owned: No
Listed since: 07-18-2025 - $41,998good price$2,368 below market
- 53,053 miles
- No accidents, 1 owner, personal use only
- 5 Seats, 19 City / 26 Hwy MPG
- Lexus of Wichita (329 mi away)
Close
Located in Wichita, KS / 329 miles away from Des Moines, IA
2022 Lexus RX 350 AWD, located at Lexus of Wichita. Original MSRP $56,775. Matador Red Mica with Parchment Leather interior. L/Certified provides up t...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA5NC316358
Stock: 54L1345T
Certified Pre-Owned: Yes
Listed since: 08-23-2025 - $42,716fair price$253 above market
- 39,782 miles
- No accidents, 1 owner, personal use
- 5 Seats, 19 City / 26 Hwy MPG
- Eddy's Toyota of Wichita (332 mi away)
Close
Located in Wichita, KS / 332 miles away from Des Moines, IA
**ONE OWNER**, **CLEAN AutoCheck**, Back-Up Camera, All-Wheel Drive, Navigation, Heated Seats, Ventilated Seats, Leather Seats, Premium Sound System, ...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: 2T2HZMDA2NC338110
Stock: IT44911
Certified Pre-Owned: No
Listed since: 08-12-2025
Showing 1 - 21 out of 1,545 listings
Consumer Reviews for the Lexus RX 350
Read recent reviews for the Lexus RX 350
Exhaust drones/vibrates between 1400/1900 RPM
AlanB, 09/30/2022
2022 Lexus RX 350 F SPORT 4dr SUV AWD (3.5L 6cyl 8A)
I have a new 2022 but the exhaust noise and corresponding vibration in the pedals and steering wheel is very annoying. Test drove another new 2022 today that did not have these issues. After two visits, a total of 11 days in the shop, and replacement of several parts the issue remains and Lexus has now washed their hands and told me that’s just too bad. It’s operating as intended in … their words, but obviously not, or they would not have worked on it two times and replaced parts. Very disappointed in Lexus quality and there their response to customer issues. If they don’t deal with this in a better fashion, they can put me down as a never again customer, and I warn everyone looking at ANY RX 350 to carefully check for this issue. All you have to do is leave the car in park, and very slowly rev the engine between idle and about 2000 RPM . If you hear any abnormal, droning , rumbling or vibrations run from the car, because Lexus will not fix it!
Used 2022 Lexus RX 350 in Des Moines, IA Values
Estimated values
2022 Lexus RX 350 4dr SUV (3.5L 6cyl 8A) with no options
| Condition | Trade-In | Private Party | Dealer Retail |
|---|---|---|---|
| Outstanding | $32,896 | $34,699 | $36,580 |
| Clean | $32,457 | $34,219 | $36,054 |
| Average | $31,727 | $33,418 | $35,178 |
| Rough | $30,777 | $32,376 | $34,038 |
The average list price of a used 2022 Lexus RX 350 in Des Moines, Iowa is $41,179. The average mileage on a used Lexus RX 350 2022 for sale in Des Moines, Iowa is 37,930. Based on the average mileage of 37,930 for used 2022 Lexus RX 350 for sale in Des Moines, IA and using an average vehicle condition rating, which means the vehicle may have a few mechanical and/or cosmetic problems and may require a considerable amount of reconditioning, we appraise the average trade-in value of a used Lexus RX 350 2022 in Des Moines, Iowa to be $31,727.
Filters
Skip to ResultsApplied Filters4Active
Make & Model
Year
New / Used
Price & Payments
Price Rating
Body Type
Trim
Mileage
Accidents & History
Engine & Drivetrain
Exterior Color
Interior Color
Total Seating
Edmunds Review
Features
Options & Packages
MPG
* Delivery of any kind does not apply to Alaska and Hawaii. Contact the dealer for delivery details, restrictions and costs.