I've owned this car for three years, I bought it used with about 25,000 miles. Overall I do love to drive this car it is very luxurious and handles very nicely. I only have a few complaints. The navigation is just really a piece of crap and I never use it. The leather on the seats start to break down very quickly, I tried to get Lexus to do something about it but they said it was it not worn enough to warrant being replaced. The cheap plastic they used on the doors around window controls started to peel and looked really cheesy but Lexus did replace those with some nice chrome plated inserts, good for them. My gas mileage is around 27 to 28 MPG and I have it regularly serviced as required. I have about 90,000 miles on it now and I would not hesitate to drive across the country, very reliable.
Best car I have ever owned and really don't want to get rid of it, but just have the itch for something different. Outstanding comfort and reliability - never, never a problem with any aspect of the car. It is virtually impossible to beat the reliability and predictability of a Toyota, and Lexus takes it to the next level.