Skip to FiltersReport abuse
172 listings
- New Listing$38,995fair price$257 above market
- 63,603 miles
- No accidents, 2 owners, personal use
- 5 Seats, 31 City / 28 Hwy MPG
- Lexus of Arlington (292 mi away)
Close
Located in Arlington Heights, IL / 292 miles away from Des Moines, IA
Elevate your driving experience with the exceptional 2021 Lexus RX 450h. This captivating SUV combines luxury, performance, and efficiency, making it ...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
30 Combined MPG (31 City/28 Highway)
Listing Information:
VIN: 2T2HGMDA7MC060891
Stock: AL1192SA
Certified Pre-Owned: No
Listed since: 09-16-2025 - Price Drop
- 49,890 miles
- No accidents, 1 owner, personal use
- 5 Seats, 31 City / 28 Hwy MPG
- Walser Toyota (226 mi away)
Close
Located in Bloomington, MN / 226 miles away from Des Moines, IA
At Walser, you’ll get an exceptional car-buying experience. Our *streamlined process* means you’ll work with one dedicated customer specialist to help...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
30 Combined MPG (31 City/28 Highway)
Listing Information:
VIN: 2T2JGMDA4MC058081
Stock: 3T2955T
Certified Pre-Owned: No
Listed since: 09-05-2025 - New Listing$39,995great price$4,927 below market
- 78,627 miles
- 5 Seats, 31 City / 28 Hwy MPG
- BMW of Columbia (193 mi away)
Close
Located in Columbia, MO / 193 miles away from Des Moines, IA
Recent Arrival! Back Up Camera, Heated Seats, Moonroof, Leather, Carfax One Owner, Head-Up Display, RX 450h, 4D Sport Utility, 3.5L V6 DOHC VVT-i 24V,...
AutoCheck Vehicle History Summary Unavailable.
Features and Specs:
30 Combined MPG (31 City/28 Highway)
Listing Information:
VIN: 2T2JGMDA9NC075914
Stock: B21027A
Certified Pre-Owned: No
Listed since: 09-19-2025 - Price Drop$43,999good price$3,641 below market
- 36,457 miles
- No accidents, 1 owner, personal use
- 5 Seats, 31 City / 28 Hwy MPG
- Tom Kadlec Honda (178 mi away)
Close
Located in Rochester, MN / 178 miles away from Des Moines, IA
Lexus RX 450h 3.5L V6 DOHC VVT-i 24V Carfax 1 owner, Clean Vehicle History Report, 3.5L V6 DOHC VVT-i 24V, AWD, Black Artificial Leather, Apple CarPla...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
30 Combined MPG (31 City/28 Highway)
Listing Information:
VIN: 2T2HGMDA5NC086262
Stock: P12129
Certified Pre-Owned: No
Listed since: 08-28-2025 - $44,560fair price$6 below market
- 47,174 miles
- No accidents, 1 owner, personal use only
- 5 Seats, 31 City / 28 Hwy MPG
- Zeigler Buick GMC of Lincolnwood (306 mi away)
Close
Located in Lincolnwood, IL / 306 miles away from Des Moines, IA
Recent Arrival! 2022 Lexus RX 450h Black AWD*, 3.5L V6 DOHC VVT-i 24V, AWD. 31/28 City/Highway MPGAt Zeigler Buick GMC of Lincolnwood, we take pride ...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
30 Combined MPG (31 City/28 Highway)
Listing Information:
VIN: 2T2HGMDA5NC073611
Stock: PA8212
Certified Pre-Owned: No
Listed since: 09-09-2025 - Price Drop$42,211fair price$120 below market
- 39,772 miles
- No accidents, 1 owner, personal use only
- 5 Seats, 31 City / 28 Hwy MPG
- Audi Creve Couer (263 mi away)
Close
Located in Creve Coeur, MO / 263 miles away from Des Moines, IA
RECALL NOTICE: Some vehicles offered for sale may be subject to unrepaired manufacturer safety recalls. To determine the recall status of a vehicle, v...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
30 Combined MPG (31 City/28 Highway)
Listing Information:
VIN: 2T2HGMDA7NC083606
Stock: PLAP220818
Certified Pre-Owned: No
Listed since: 06-30-2025 - Price Drop$45,999fair price$206 above market
- 19,468 miles
- No accidents, 1 owner, personal use
- 5 Seats, 31 City / 28 Hwy MPG
- Tom Kadlec Honda (178 mi away)
Close
Located in Rochester, MN / 178 miles away from Des Moines, IA
Lexus RX 450h 3.5L V6 DOHC VVT-i 24V Carfax 1 owner, Clean Vehicle History Report, 3.5L V6 DOHC VVT-i 24V, AWD, Black Artificial Leather, Air Conditio...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
30 Combined MPG (31 City/28 Highway)
Listing Information:
VIN: 2T2HGMDA2NC086834
Stock: P12126
Certified Pre-Owned: No
Listed since: 08-25-2025 - Price Drop$46,990fair price$277 above market
- 20,261 miles
- No accidents, 2 owners, personal use only
- 5 Seats, 31 City / 28 Hwy MPG
- Unlimited Motors Westfield (404 mi away)
Close
Located in Westfield, IN / 404 miles away from Des Moines, IA
Back Up Camera, Bluetooth, Sun/Moon Roof, Heated Seats, Touch Screen, Cooled Heats, Blind Spot, Heated Steering Wheel, RX 450h F Sport, 4D Sport Utili...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
30 Combined MPG (31 City/28 Highway)
Listing Information:
VIN: 2T2SGMDAXNC083993
Stock: STK083993
Certified Pre-Owned: No
Listed since: 07-18-2025 - Price Drop$43,250fair price$822 below market
- 37,087 miles
- 1 accident, 1 owner, personal use
- 5 Seats, 31 City / 28 Hwy MPG
- Unlimited Motors Elwood (417 mi away)
Close
Located in Elwood, IN / 417 miles away from Des Moines, IA
Navigation, Back Up Camera, Sunroof, Bluetooth, Touch Screen, Heated Seats, Heated Steering Wheel, Power Lift Gate, Blind Spot, Low Miles, Lane Assist...
AutoCheck Vehicle History Summary
Accident Free Vehicle: No
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
30 Combined MPG (31 City/28 Highway)
Listing Information:
VIN: 2T2HGMDA7NC092919
Stock: STK092919
Certified Pre-Owned: No
Listed since: 07-18-2025 - 37,097 miles
- No accidents, 1 owner, personal use
- 5 Seats, 31 City / 28 Hwy MPG
- Fields Lexus Glenview (302 mi away)
Close
Located in Glenview, IL / 302 miles away from Des Moines, IA
JUST IN! This one-owner, clean CARFAX, GORGEOUS, Black / Black RX450H Hybrid AWD! Meticulously maintained and exquisitely equipped, with Luxury, cold ...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
30 Combined MPG (31 City/28 Highway)
Listing Information:
VIN: 2T2JGMDA0NC083156
Stock: L251293A
Certified Pre-Owned: Yes
Listed since: 09-04-2025- 44,351 miles
- No accidents, 1 owner, personal use
- 5 Seats, 31 City / 28 Hwy MPG
- Unlimited Motors Noblesville (410 mi away)
Close
Located in Noblesville, IN / 410 miles away from Des Moines, IA
4x4, AWD, Back Up Camera, Bluetooth, Heated Seats, Sun/Moon Roof, Push Button Start, and much more ..., Touch Screen, RX 450h, 4D Sport Utility, 3.5L ...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
30 Combined MPG (31 City/28 Highway)
Listing Information:
VIN: 2T2HGMDA2NC084338
Stock: STK084338
Certified Pre-Owned: No
Listed since: 07-28-2025- New ListingNot Priced
- 81,747 miles
- No accidents, 1 owner, personal use only
- 5 Seats, 31 City / 28 Hwy MPG
- Twins Chrysler Dodge Jeep RAM of Wayland (416 mi away)
Close
Located in Wayland, MI / 416 miles away from Des Moines, IA
Twins Chrysler Dodge Jeep Ram is proud to offer all new vehicles at ZERO MARKUP to our customers! All new vehicles are priced at or below our cost! Br...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
30 Combined MPG (31 City/28 Highway)
Listing Information:
VIN: 2T2HGMDAXNC076584
Stock: U02040
Certified Pre-Owned: No
Listed since: 09-19-2025 - $39,591great price$5,673 below market
- 44,164 miles
- No accidents, 2 owners, personal use
- 5 Seats, 31 City / 28 Hwy MPG
- Roadshow MINI (492 mi away)
Close
Located in Cordova, TN / 492 miles away from Des Moines, IA
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
30 Combined MPG (31 City/28 Highway)
Listing Information:
VIN: 2T2JGMDA3MC067404
Stock: 32481H
Certified Pre-Owned: No
Listed since: 08-03-2025 - $36,724good price$2,797 below market
- 91,656 miles
- No accidents, 1 owner, personal use only
- 5 Seats, 31 City / 28 Hwy MPG
- Hendrick Lexus Kansas City North (170 mi away)
Close
Located in Kansas City, MO / 170 miles away from Des Moines, IA
3 month / 3k mile Hendrick Affordable Warranty, Very well maintained, we have the records to prove it! Originally purchased new from our store. Just t...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
30 Combined MPG (31 City/28 Highway)
Listing Information:
VIN: 2T2JGMDAXMC070588
Stock: S58662A
Certified Pre-Owned: No
Listed since: 09-14-2025 - New Listing$39,990great price$2,256 below market
- 53,059 miles
- 5 Seats, 31 City / 28 Hwy MPG
- Carvana (In-stock online)
- Home delivery*
Close
Located in Sacramento, CA / 1,480 miles away from Des Moines, IA
At Carvana, we go miles beyond the extra mile. That's why we provide you with a convenient, fast, and hassle-free car buying experience that puts you ...
AutoCheck Vehicle History Summary Unavailable.
Features and Specs:
30 Combined MPG (31 City/28 Highway)
Listing Information:
VIN: 2T2SGMDA1MC057409
Stock: 2004094723
Certified Pre-Owned: No
Listed since: 09-20-2025 - $40,998great price$4,247 below market
- 49,920 miles
- No accidents, 1 owner, personal use only
- 5 Seats, 31 City / 28 Hwy MPG
- CarMax (In-stock online)
- Transfer available from AZ to IA*
Close
Located in Gilbert, AZ / 1,145 miles away from Des Moines, IA
CarMax values transparency and wants you to love your next car, not settle on it. Certain vehicles may have unrepaired safety recalls. Check nhtsa.gov...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
30 Combined MPG (31 City/28 Highway)
Listing Information:
VIN: 2T2JGMDA1MC064694
Stock: 27621349
Certified Pre-Owned: No - New Listing$43,998good price$3,177 below market
- 34,764 miles
- 5 Seats, 31 City / 28 Hwy MPG
- CarMax (In-stock online)
- Transfer available from NV to IA*
Close
Located in Henderson, NV / 1,210 miles away from Des Moines, IA
CarMax values transparency and wants you to love your next car, not settle on it. Certain vehicles may have unrepaired safety recalls. Check nhtsa.gov...
AutoCheck Vehicle History Summary Unavailable.
Features and Specs:
30 Combined MPG (31 City/28 Highway)
Listing Information:
VIN: 2T2YGMDA9MC060505
Stock: 26477403
Certified Pre-Owned: No - $37,498fair price$793 above market
- 49,805 miles
- No accidents, 2 owners, personal use
- 5 Seats, 31 City / 28 Hwy MPG
- Lexus of Brookfield (297 mi away)
- Five Star Dealer
Close
Located in Brookfield, WI / 297 miles away from Des Moines, IA
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
30 Combined MPG (31 City/28 Highway)
Listing Information:
VIN: 2T2BGMCA1KC037255
Stock: PWS2808
Certified Pre-Owned: Yes
Listed since: 09-03-2025 - New Listing$39,990fair price$612 above market
- 37,064 miles
- No accidents, 1 owner, personal use
- 5 Seats, 31 City / 28 Hwy MPG
- Carvana - Oklahoma City (472 mi away)
- Home delivery*
Close
Located in Oklahoma City, OK / 472 miles away from Des Moines, IA
At Carvana, we go miles beyond the extra mile. That's why we provide you with a convenient, fast, and hassle-free car buying experience that puts you ...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
30 Combined MPG (31 City/28 Highway)
Listing Information:
VIN: 2T2BGMCAXKC040106
Stock: 2004066783
Certified Pre-Owned: No
Listed since: 09-17-2025 - New Listing$37,445fair price$868 above market
- 86,255 miles
- No accidents, 2 owners, personal use
- 5 Seats, 31 City / 28 Hwy MPG
- Harvey Lexus of Grand Rapids (420 mi away)
Close
Located in Grand Rapids, MI / 420 miles away from Des Moines, IA
VERY HARD TO FINE, ONE OWNER, LOCAL TRADE IN! PURCHASED NEW AND SERVICED HERE AT HARVEY LEXUS!! 2021 LEXUS RX 450H HYBRID ALL WHEEL DRIVE LUXURY SUV! ...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
30 Combined MPG (31 City/28 Highway)
Listing Information:
VIN: 2T2JGMDA1MC062153
Stock: 198-L25
Certified Pre-Owned: No
Listed since: 09-11-2025 - Price Drop
- 24,922 miles
- No accidents, 1 owner, personal use
- 5 Seats, 31 City / 28 Hwy MPG
- CarMax (In-stock online)
- Transfer available from SC to IA*
Close
Located in Columbia, SC / 856 miles away from Des Moines, IA
CarMax values transparency and wants you to love your next car, not settle on it. Certain vehicles may have unrepaired safety recalls. Check nhtsa.gov...
AutoCheck Vehicle History Summary
Accident Free Vehicle: Yes
Personal Use Only: Yes
History Provider: AutoCheck
Title Details: Clean Title
Salvage Vehicle: No
Frame Damage: No
Theft History: No
Lemon Status: No
Free History Report: No
Features and Specs:
30 Combined MPG (31 City/28 Highway)
Listing Information:
VIN: 2T2HGMDA1MC072048
Stock: 27872896
Certified Pre-Owned: No
Showing 1 - 21 out of 172 listings
Consumer Reviews for the Lexus RX 450h
Read recent reviews for the Lexus RX 450h
My Atomic Silver Ride!
markh, 11/25/2019
2020 Lexus RX 450h F SPORT Performance 4dr SUV AWD (3.5L 6cyl gas/electric hybrid CVT)
I graduated from a 2017 RX 350 to the 2020 RX 450h Performance F Sport and love it! I love the feel and sound when I put it in Sport mode, but most of the time I keep it in Eco Mode for improved mileage. In Sport mode the gas pedal is soft, whereas in Eco mode it seems as the pedal is harder to push, saving fuel? The car is very similar to my 2017 inside, except the speedometer … area. There is no space under the back seats to stick my car wash rags or umbrella since the battery is in that area. (not a problem). The RX 450h has a smaller fuel tank then the RX 350 but I am getting around a 100 miles more between fill ups with the RX 450h. The only drawback is the RX 450h does require 93 octane which compared to an RX 350 that burns 87 octane there is only a slight cost savings on fuel. Currently I am getting exactly what the estimated mileage on the sticker says....
Used 2021 Lexus RX 450h in Des Moines, IA Values
Estimated values
2021 Lexus RX 450h 4dr SUV AWD (3.5L 6cyl gas/electric hybrid CVT) with no options
| Condition | Trade-In | Private Party | Dealer Retail |
|---|---|---|---|
| Outstanding | $31,262 | $33,999 | $36,739 |
| Clean | $30,774 | $33,459 | $36,146 |
| Average | $29,960 | $32,559 | $35,158 |
| Rough | $28,902 | $31,389 | $33,874 |
The average list price of a used 2021 Lexus RX 450h in Des Moines, Iowa is $42,476. The average mileage on a used Lexus RX 450h 2021 for sale in Des Moines, Iowa is 48,912. Based on the average mileage of 48,912 for used 2021 Lexus RX 450h for sale in Des Moines, IA and using an average vehicle condition rating, which means the vehicle may have a few mechanical and/or cosmetic problems and may require a considerable amount of reconditioning, we appraise the average trade-in value of a used Lexus RX 450h 2021 in Des Moines, Iowa to be $29,960.
Filters
Skip to ResultsApplied Filters4Active
Make & Model
Year
New / Used
Price & Payments
Price Rating
Body Type
Trim
Mileage
Accidents & History
Engine & Drivetrain
Exterior Color
Interior Color
Total Seating
Edmunds Review
Features
Options & Packages
MPG
* Delivery of any kind does not apply to Alaska and Hawaii. Contact the dealer for delivery details, restrictions and costs.