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179 listings
  • Price Drop
    • 57,394 miles
    • No accidents, 2 owners, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • BMW of Topeka (208 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    Close

    Located in Topeka, KS / 208 miles away from Des Moines, IA

    Why Choose Aristocrat Motors of Topeka? At Aristocrat Motors of Topeka, our commitment begins with delivering an exceptional automotive experience wit...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2YGMDA1MC063771
    Stock: B1850B
    Certified Pre-Owned: No
    Listed since: 09-09-2025

  • Price Drop
    • 41,600 miles
    • No accidents, 2 owners, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Driveway (In-stock online)
    • Home delivery*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Medford, OR / 1,491 miles away from Des Moines, IA

    CarFax No Accidents Reported,Rare Find,Green Vehicle,Apple CarPlay,Back-Up Camera,Blind Spot Monitor,Bluetooth,Brake Assist,Heated Seats,Heated Steeri...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2YGMDA1MC057095
    Stock: MC057095H
    Certified Pre-Owned: No

  • Price Drop
    $44,444
    great price
    $5,706 below market
    • 20,796 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Old Orchard Nissan (304 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Skokie, IL / 304 miles away from Des Moines, IA

    2022 Lexus RX eCVT 3.5L V6 DOHC VVT-i 24V, AWD, Black Artificial Leather, 18" Aluminum Wheels, Power driver seat, Power Liftgate, Rain sensing wipers....

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA3NC085756
    Stock: T1344
    Certified Pre-Owned: No
    Listed since: 08-16-2025

  • Price Drop
    $43,590
    great price
    $8,561 below market
    • 37,221 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Carvana (In-stock online)
    • Home delivery*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Las Vegas, NV / 1,214 miles away from Des Moines, IA

    At Carvana, we go miles beyond the extra mile. That's why we provide you with a convenient, fast, and hassle-free car buying experience that puts you ...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2JGMDA1NC089127
    Stock: 2003775711
    Certified Pre-Owned: No
    Listed since: 05-30-2025

  • Price Drop
    $39,545
    great price
    $6,378 below market
    • 62,077 miles
    • No accidents, 2 owners, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Lexus of Fort Wayne (438 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Fort Wayne, IN / 438 miles away from Des Moines, IA

    Experience true luxury at Lexus of Fort Wayne. From personalized service to world-class hospitality, your journey to exceptional driving begins here.T...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA6NC089963
    Stock: FL1539P
    Certified Pre-Owned: Yes
    Listed since: 08-02-2025

  • Price Drop
    • 68,600 miles
    • No accidents, 2 owners, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Spirit Lexus (264 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in St. Louis, MO / 264 miles away from Des Moines, IA

    Certified. Grecian Water 2022 Lexus RX 450h F Sport AWD eCVT 3.5L V6 DOHC VVT-i 24V ** LOCAL TRADE **, **ANDROID AUTO**, **APPLE CARPLAY**, **AWD**, *...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2YGMDA0NC076013
    Stock: P8N076013
    Certified Pre-Owned: Yes
    Listed since: 08-09-2025

  • New Listing
    • 102,888 miles
    • Issue reported, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Victory Toyota of St. Louis (274 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Leather Seats
    Close

    Located in Saint Louis, MO / 274 miles away from Des Moines, IA

    This luxurious and efficient 2019 Lexus RX 450h Hybrid with 102k miles was privately acquired by our team here at Victory Toyota St. Louis. With hybri...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: No

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Issue reported

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2BGMCAXKC034676
    Stock: 86E09519
    Certified Pre-Owned: No
    Listed since: 09-16-2025

  • New Listing
    $41,716
    great price
    $4,310 below market
    • 53,866 miles
    • No accidents, 2 owners, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Driveway (In-stock online)
    • Home delivery*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Leather Seats
    Close

    Located in Lexington, KY / 550 miles away from Des Moines, IA

    Rare Find,Green Vehicle,Apple CarPlay,Back-Up Camera,Blind Spot Monitor,Bluetooth,Brake Assist,Heated Seats,Heated Steering Wheel,Keyless Start,Lane K...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2JGMDA3NC088898
    Stock: NC088898A
    Certified Pre-Owned: No

  • New Listing
    $43,500
    great price
    $5,211 below market
    • 46,800 miles
    • 5 Seats, 31 City / 28 Hwy MPG
    • Serra Lexus Lansing (476 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Okemos, MI / 476 miles away from Des Moines, IA

    CARFAX One-Owner. Clean CARFAX.RX 450h, 4D Sport Utility, 3.5L V6 DOHC VVT-i 24V, eCVT, AWD, Black w/NuLuxe Seat Trim, 12.3 Navigation System w/Mark L...

    AutoCheck Vehicle History Summary Unavailable.

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2JGMDA5NC088692
    Stock: L25635B
    Certified Pre-Owned: No
    Listed since: 09-08-2025

  • $45,500
    good price
    $4,090 below market
    • 52,835 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Lux Cars Chicago (294 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Leather Seats
    Close

    Located in Buffalo Grove, IL / 294 miles away from Des Moines, IA

    2022 LEXUS RX 450H AWD HYBRID SUV WITH 3.5L V6 HYBRID DRIVE SYSTEM AND CVT TRANSMISSION WITH PADDLE SHIFTERS. SOPHISTICATED NEBULA GRAY PEARL EXTERIOR...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2JGMDA8NC094776
    Stock: 9910
    Certified Pre-Owned: No
    Listed since: 08-13-2025

  • Price Drop
    $40,990
    good price
    $3,312 below market
    • 38,147 miles
    • No accidents, 1 owner, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Carvana (In-stock online)
    • Home delivery*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Leather Seats
    Close

    Located in Columbus, OH / 567 miles away from Des Moines, IA

    At Carvana, we go miles beyond the extra mile. That's why we provide you with a convenient, fast, and hassle-free car buying experience that puts you ...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2JGMDA9LC050928
    Stock: 2003964728
    Certified Pre-Owned: No
    Listed since: 08-28-2025

  • New Listing
    $47,448
    good price
    $2,268 below market
    • 22,127 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Golden Circle Ford Lincoln (485 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Jackson, TN / 485 miles away from Des Moines, IA

    FREE 20 YEAR / 200,000 MILE POWERTRAIN WARRANTY, ONE OWNER, CLEAN CARFAX, AWD ALL WHEEL DRIVE, BLUETOOTH, SIRIUS XM SATELLITE RADIO, APPLE CARPLAY, GO...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA9NC074180
    Stock: 1574238A
    Certified Pre-Owned: No
    Listed since: 09-17-2025

  • $43,788
    good price
    $2,374 below market
    • 45,449 miles
    • No accidents, 1 owner, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Frank Leta Acura (274 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Saint Louis, MO / 274 miles away from Des Moines, IA

    Certified! 90 Day/3,000 Mile Limited Comprehensive Warranty and a 7 Year/100,000 Mile Limited Powertrain Warranty! One Owner/CARFAX No Accidents! Comp...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA5NC090120
    Stock: PJK2104
    Certified Pre-Owned: No
    Listed since: 09-06-2025

  • $32,900
    good price
    $2,168 below market
    • 83,800 miles
    • No accidents, 2 owners, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Genesis of Bloomington-Normal (255 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Normal, IL / 255 miles away from Des Moines, IA

    Heated Seats, Moonroof, Nav System, iPod/MP3 Input, Satellite Radio, Hybrid, Power Liftgate, All Wheel Drive, POWER TILT & SLIDE MOONROOF, HEATED WOOD...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA4LC046168
    Stock: G007015A
    Certified Pre-Owned: No
    Listed since: 08-17-2025

  • Stock photo**
    $38,995
    good price
    $2,940 below market
    • 53,443 miles
    • No accidents, 2 owners, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Zimbrick Volkswagen of Madison (244 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Leather Seats
    Close

    Located in Madison, WI / 244 miles away from Des Moines, IA

    CARFAX One-Owner. Clean CARFAX.This Lexus RX is well equipped and includes these key features:, SERVICED HERE, 3.5L V6 DOHC VVT-i 24V, AWD.Odometer is...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2JGMDAXLC056110
    Stock: 52954
    Certified Pre-Owned: No
    Listed since: 08-26-2025

  • $47,998
    fair price
    $69 below market
    • 29,195 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • CarMax (In-stock online)
    • Transfer available from VA to IA*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Roanoke, VA / 784 miles away from Des Moines, IA

    CarMax values transparency and wants you to love your next car, not settle on it. Certain vehicles may have unrepaired safety recalls. Check nhtsa.gov...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA5NC090215
    Stock: 27842395
    Certified Pre-Owned: No

  • $44,519
    fair price
    $541 above market
    • 35,187 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Driveway (In-stock online)
    • Home delivery*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Sunroof/Moonroof
    • Keyless Entry/Start
    Close

    Located in Middletown, NY / 992 miles away from Des Moines, IA

    CarFax No Accidents Reported,CarFax 1-Owner,Green Vehicle,Apple CarPlay,Back-Up Camera,Blind Spot Monitor,Bluetooth,Brake Assist,Heated Seats,Heated S...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA6NC087324
    Stock: NC087324T
    Certified Pre-Owned: No

    • 29,287 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Carvana (In-stock online)
    • Home delivery*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Dallas, TX / 631 miles away from Des Moines, IA

    At Carvana, we go miles beyond the extra mile. That's why we provide you with a convenient, fast, and hassle-free car buying experience that puts you ...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2JGMDA5NC081130
    Stock: 2003978237
    Certified Pre-Owned: No
    Listed since: 08-27-2025

  • Price Drop
    $44,988
    fair price
    $1,144 below market
    • 44,536 miles
    • No accidents, 2 owners, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Landers Toyota (480 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Little Rock, AR / 480 miles away from Des Moines, IA

    Heated Seats, Moonroof, Nav System, iPod/MP3 Input, Satellite Radio, Hybrid, Power Liftgate, All Wheel Drive, PANORAMIC-VIEW MONITOR W/RR CROSS-TRA. P...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDAXNC081414
    Stock: C081414L
    Certified Pre-Owned: No
    Listed since: 04-13-2025

  • New Listing
    $50,998
    fair price
    $905 above market
    • 17,441 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • CarMax (In-stock online)
    • Transfer available from CO to IA*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Colorado Springs, CO / 613 miles away from Des Moines, IA

    CarMax values transparency and wants you to love your next car, not settle on it. Certain vehicles may have unrepaired safety recalls. Check nhtsa.gov...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA4NC088830
    Stock: 27630420
    Certified Pre-Owned: No

  • New Listing
    $37,998
    fair price
    $395 above market
    • 63,309 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • CarMax (In-stock online)
    • Transfer available from MD to IA*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Ellicott City, MD / 897 miles away from Des Moines, IA

    CarMax values transparency and wants you to love your next car, not settle on it. Certain vehicles may have unrepaired safety recalls. Check nhtsa.gov...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2JGMDA6LC056895
    Stock: 27729828
    Certified Pre-Owned: No

Showing 22 - 42 out of 179 listings

Consumer Reviews for the Lexus RX 450h

Read recent reviews for the Lexus RX 450h
Overall Consumer Rating
4.4 out of 5 stars33 Reviews
Write a vehicle reviewSee all 33 reviews
  • 5 star
    (67%)
  • 4 star
    (18%)
  • 3 star
    (9%)
  • 2 star
    (0%)
  • 1 star
    (6%)
5 out of 5 stars

My Atomic Silver Ride!

markh, 11/25/2019
2020 Lexus RX 450h F SPORT Performance 4dr SUV AWD (3.5L 6cyl gas/electric hybrid CVT)
I graduated from a 2017 RX 350 to the 2020 RX 450h Performance F Sport and love it! I love the feel and sound when I put it in Sport mode, but most of the time I keep it in Eco Mode for improved mileage. In Sport mode the gas pedal is soft, whereas in Eco mode it seems as the pedal is harder to push, saving fuel? The car is very similar to my 2017 inside, except the speedometer … area. There is no space under the back seats to stick my car wash rags or umbrella since the battery is in that area. (not a problem). The RX 450h has a smaller fuel tank then the RX 350 but I am getting around a 100 miles more between fill ups with the RX 450h. The only drawback is the RX 450h does require 93 octane which compared to an RX 350 that burns 87 octane there is only a slight cost savings on fuel. Currently I am getting exactly what the estimated mileage on the sticker says....
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Used 2021 Lexus RX 450h in Des Moines, IA Values

Estimated values
2021 Lexus RX 450h F SPORT Handling 4dr SUV AWD (3.5L 6cyl gas/electric hybrid CVT) with no options
ConditionTrade-InPrivate PartyDealer Retail
Outstanding$34,655$37,015$39,378
Clean$34,113$36,427$38,742
Average$33,211$35,447$37,683
Rough$32,038$34,174$36,307

The average list price of a used 2021 Lexus RX 450h in Des Moines, Iowa is $42,435. The average mileage on a used Lexus RX 450h 2021 for sale in Des Moines, Iowa is 47,905. Based on the average mileage of 47,905 for used 2021 Lexus RX 450h for sale in Des Moines, IA and using an average vehicle condition rating, which means the vehicle may have a few mechanical and/or cosmetic problems and may require a considerable amount of reconditioning, we appraise the average trade-in value of a used Lexus RX 450h 2021 in Des Moines, Iowa to be $33,211.

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* Delivery of any kind does not apply to Alaska and Hawaii. Contact the dealer for delivery details, restrictions and costs.