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3,081 listings
    • 40,130 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 19 City / 26 Hwy MPG
    • El Compadre Trucks (186 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Sunroof/Moonroof
    • Keyless Entry/Start
    Close

    Located in Atlanta, GA / 186 miles away from Columbia, SC

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    22 Combined MPG (19 City/26 Highway)

    Listing Information:

    VIN: 2T2YZMDA0MC285423
    Stock: 285423
    Certified Pre-Owned: No
    Listed since: 04-24-2025

    • 9,961 miles
    • 1 accident, 1 owner, personal use
    • 5 Seats, 21 City / 28 Hwy MPG
    • Ourisman Lexus of Rockville (407 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Sunroof/Moonroof
    • Keyless Entry/Start
    Close

    Located in Rockville, MD / 407 miles away from Columbia, SC

    Certified. L/CERTIFIED, F SPORT PKG, APPLE CAR PLAY/ANDROID AUTO, HEATED STEERING WHEEL, HEATED AND VENTILATED SEATS, WIRELESS CHARGER, HEADS UP DISPL...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: No

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    24 Combined MPG (21 City/28 Highway)

    Listing Information:

    VIN: 2T2BAMCA8PC014905
    Stock: ZC014905
    Certified Pre-Owned: Yes
    Listed since: 06-16-2025

  • New Listing
    • 38,983 miles
    • No accidents, 1 owner, personal use
    • 5 Seats, 19 City / 26 Hwy MPG
    • Brambleton Imports (225 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Roanoke, VA / 225 miles away from Columbia, SC

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    22 Combined MPG (19 City/26 Highway)

    Listing Information:

    VIN: 2T2HZMDA7MC282552
    Stock: 2040
    Certified Pre-Owned: No
    Listed since: 03-27-2025

  • New Listing
    • 41,276 miles
    • No accidents, 2 owners, personal use only
    • 5 Seats, 20 City / 27 Hwy MPG
    • Perkins Motor Plex Mayfield (466 mi away)
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    • Blind Spot Monitorin...
    Close

    Located in Mayfield, KY / 466 miles away from Columbia, SC

    **FULLY SERVICED AND INSPECTED** **30 DAY POWERTRAIN PLUS WARRANTY**.....SUNROOF....BACKUP CAMERA....AUX/USB....BLUETOOTH....BLINDSPOT SYSTEM....HEATE...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    23 Combined MPG (20 City/27 Highway)

    Listing Information:

    VIN: 2T2HZMAA0MC183737
    Stock: 183737
    Certified Pre-Owned: No
    Listed since: 06-11-2025

    • 85,435 miles
    • No accidents, 2 owners, personal use
    • 5 Seats, 20 City / 27 Hwy MPG
    • Boniface-Hiers Chrysler Dodge Jeep RAM (397 mi away)
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    • Blind Spot Monitorin...
    Close

    Located in Cocoa, FL / 397 miles away from Columbia, SC

    2021 Lexus RX 350 3503.5L V6 DOHC 24V RX 350, 4D Sport Utility, 3.5L V6 DOHC 24V, 8-Speed Automatic, FWD, Caviar, Black Artificial Leather, CUSTOMER ...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    23 Combined MPG (20 City/27 Highway)

    Listing Information:

    VIN: 2T2HZMAA7MC197361
    Stock: DPT1112
    Certified Pre-Owned: No
    Listed since: 03-31-2025

    • 39,058 miles
    • No accidents, 1 owner, personal use
    • 5 Seats, 20 City / 27 Hwy MPG
    • Master Buick GMC (72 mi away)
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    • Blind Spot Monitorin...
    Close

    Located in Augusta, GA / 72 miles away from Columbia, SC

    This vehicle is located at Master Chevrolet Cadillac in Aiken, SC!One Owner Clean CARFAX.2021 Lexus RX 350 3.5L V6 DOHC 24V MoonbeamLooking for a luxu...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    23 Combined MPG (20 City/27 Highway)

    Listing Information:

    VIN: 2T2AZMAA6MC196008
    Stock: 6008WP
    Certified Pre-Owned: No
    Listed since: 06-12-2025

    • 76,471 miles
    • No accidents, 2 owners, personal use
    • 5 Seats, 20 City / 27 Hwy MPG
    • Tameron Hyundai (335 mi away)
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    • Blind Spot Monitorin...
    Close

    Located in Hoover, AL / 335 miles away from Columbia, SC

    Beige 2021 Lexus RX 350 FWD 8-Speed Automatic 3.5L V6 DOHC 24V Parchment w/NuLuxe Seat Trim, Moonroof/Sunrof, Power Lift Gate, Backup Camera, Clean ac...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    23 Combined MPG (20 City/27 Highway)

    Listing Information:

    VIN: 2T2HZMAA4MC200068
    Stock: P13698
    Certified Pre-Owned: No
    Listed since: 03-18-2025

    • 126,379 miles
    • No accidents, 2 owners, personal use only
    • 5 Seats, 20 City / 27 Hwy MPG
    • Pierce County Auto (207 mi away)
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    • Keyless Entry/Start
    Close

    Located in Blackshear, GA / 207 miles away from Columbia, SC

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    23 Combined MPG (20 City/27 Highway)

    Listing Information:

    VIN: 2T2HZMAA4MC182624
    Stock: 8351
    Certified Pre-Owned: No
    Listed since: 05-17-2025

    • 128,922 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 20 City / 27 Hwy MPG
    • Triple M Motors (499 mi away)
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    • Blind Spot Monitorin...
    Close

    Located in Carthage, MS / 499 miles away from Columbia, SC

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    23 Combined MPG (20 City/27 Highway)

    Listing Information:

    VIN: 2T2HZMAA7MC204230
    Stock: 04230
    Certified Pre-Owned: No
    Listed since: 05-28-2025

  • $37,188
    fair price
    $410 above market
    • 49,617 miles
    • No accidents, 2 owners, personal use
    • 5 Seats, 20 City / 27 Hwy MPG
    • Driveway (In-stock online)
    • Home delivery*
    • Back-up camera
    • Bluetooth
    • Sunroof/Moonroof
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Valencia, CA / 2,132 miles away from Columbia, SC

    Apple CarPlay,Back-Up Camera,Blind Spot Monitor,Bluetooth,Brake Assist,Heated Seats,Heated Steering Wheel,Keyless Start,Lane Keeping Assist,Navigation...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    23 Combined MPG (20 City/27 Highway)

    Listing Information:

    VIN: 2T2HZMAA8MC192136
    Stock: MC192136P
    Certified Pre-Owned: No

    • 22,011 miles
    • No accidents, 2 owners, personal use only
    • 5 Seats, 21 City / 28 Hwy MPG
    • Haley Buick GMC Airport (313 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Richmond, VA / 313 miles away from Columbia, SC

    *** THIS VEHICLE IS LOCATED @ HALEY BUICK GMC AIRPORT 5500 S. Laburnum Ave. Richmond VA, 23231. CALL *** 804-222-4600 *** for more information and ava...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    24 Combined MPG (21 City/28 Highway)

    Listing Information:

    VIN: 2T2BAMCA2PC035863
    Stock: XN318
    Certified Pre-Owned: No
    Listed since: 06-06-2025

  • Price Drop
    • 55,916 miles
    • No accidents, 1 owner, personal use
    • 5 Seats, 20 City / 27 Hwy MPG
    • Robinson Toyota (457 mi away)
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    • Blind Spot Monitorin...
    Close

    Located in Jackson, TN / 457 miles away from Columbia, SC

    New Price! No Maintenance for the first year, or 10,000 miles on all Pre owned vehicles. Only at Robinson Toyota! CARFAX One-Owner. Lexus RX 350 FWD 3...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    23 Combined MPG (20 City/27 Highway)

    Listing Information:

    VIN: 2T2AZMAA5MC199353
    Stock: P11192
    Certified Pre-Owned: No
    Listed since: 04-03-2025

    • 56,061 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 19 City / 26 Hwy MPG
    • Union Park Buick GMC (494 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Sunroof/Moonroof
    • Keyless Entry/Start
    Close

    Located in Wilmington, DE / 494 miles away from Columbia, SC

    Priced below KBB Fair Purchase Price! Recent Arrival! CARFAX One-Owner. This 2021 Obsidian Lexus RX 350 AWD is well equipped and includes these f...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    22 Combined MPG (19 City/26 Highway)

    Listing Information:

    VIN: 2T2HZMDA1MC298052
    Stock: W34930B
    Certified Pre-Owned: No
    Listed since: 06-08-2025

  • New Listing
    • 10,580 miles
    • 1 accident, 1 owner, personal use only
    • 5 Seats, 21 City / 28 Hwy MPG
    • CarMax Columbus Easton (425 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Leather Seats
    • Sunroof/Moonroof
    Close

    Located in Columbus, OH / 425 miles away from Columbia, SC

    CarMax values transparency and wants you to love your next car, not settle on it. Certain vehicles may have unrepaired safety recalls. Check nhtsa.gov...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: No

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    24 Combined MPG (21 City/28 Highway)

    Listing Information:

    VIN: 2T2BAMCA5PC032228
    Stock: 26950056
    Certified Pre-Owned: No

    • 68,637 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 19 City / 26 Hwy MPG
    • IAD Auto (406 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Sunroof/Moonroof
    • Keyless Entry/Start
    Close

    Located in Landover, MD / 406 miles away from Columbia, SC

    2021 Lexus RX 350 AWD 3.5L V6 DOHC 24V Nebula Gray PearlOne Owner, Non-Smoker, Clean AutoCheck, RX 350, 4D Sport Utility, 3.5L V6 DOHC 24V, 8-Speed Au...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    22 Combined MPG (19 City/26 Highway)

    Listing Information:

    VIN: 2T2HZMDA8MC268983
    Stock: IAD9193
    Certified Pre-Owned: No
    Listed since: 04-07-2025

    • 52,813 miles
    • No accidents, 2 owners, personal use
    • 5 Seats, 20 City / 27 Hwy MPG
    • Allen Turner Genesis (441 mi away)
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    • Blind Spot Monitorin...
    Close

    Located in Pensacola, FL / 441 miles away from Columbia, SC

    Eminent White Pearl 2021 Lexus RX 350 FWD 8-Speed Automatic 3.5L V6 DOHC 24V ADAPTIVE CRUISE CONTROL, COLLISION AVOIDANCE SYSTEM, COLLISION WARNING A...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    23 Combined MPG (20 City/27 Highway)

    Listing Information:

    VIN: 2T2AZMAA6MC194467
    Stock: B194467
    Certified Pre-Owned: No
    Listed since: 05-21-2025

  • Price Drop
    $36,995
    great price
    $6,910 below market
    • 77,903 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 20 City / 27 Hwy MPG
    • Reeder Chevrolet (211 mi away)
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    • Blind Spot Monitorin...
    Close

    Located in Knoxville, TN / 211 miles away from Columbia, SC

    Glazed Caramel Artificial Leather.Reeder Chevrolet is pleased to offer you this great-looking 2022 Lexus RX with the following options and features Gl...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    23 Combined MPG (20 City/27 Highway)

    Listing Information:

    VIN: 2T2JZMAA1NC251059
    Stock: NC251059
    Certified Pre-Owned: No
    Listed since: 05-22-2025

    • 32,390 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 19 City / 26 Hwy MPG
    • Genesis of North Cincinnati (402 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Cincinnati, OH / 402 miles away from Columbia, SC

    Nightfall Mica 2021 Lexus RX 350 AWD 8-Speed Automatic 3.5L V6 DOHC 24V AWD, Black Artificial Leather, 12.3" Navigation System, Apple CarPlay/Android ...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    22 Combined MPG (19 City/26 Highway)

    Listing Information:

    VIN: 2T2HZMDA3MC261567
    Stock: G1014P
    Certified Pre-Owned: No
    Listed since: 03-04-2025

  • New Listing
    Stock photo**
    • 34,417 miles
    • No accidents, 2 owners, personal use
    • 5 Seats, 21 City / 28 Hwy MPG
    • Lexus of Towson (441 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Leather Seats
    • Sunroof/Moonroof
    Close

    Located in Towson, MD / 441 miles away from Columbia, SC

    2023 Lexus RX 350 Green AWD 8-Speed Automatic 2.4L I4 PDI Turbocharged DOHC 16V LEV3-SULEV30 275hpAWD, Brown Artificial Leather, 12 Speakers, 19" Whee...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    24 Combined MPG (21 City/28 Highway)

    Listing Information:

    VIN: 2T2BAMCA5PC003179
    Stock: BT1696
    Certified Pre-Owned: No
    Listed since: 06-25-2025

  • Stock photo**
    • 52,228 miles
    • No accidents, 2 owners, personal use
    • 5 Seats, 19 City / 26 Hwy MPG
    • Dick Smith Hyundai Greenville (89 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Greenville, SC / 89 miles away from Columbia, SC

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    22 Combined MPG (19 City/26 Highway)

    Listing Information:

    VIN: 2T2BZMCA1KC177722
    Stock: HY14356A
    Certified Pre-Owned: No
    Listed since: 06-16-2025

    • 53,731 miles
    • No accidents, 1 owner, personal use
    • 5 Seats, 19 City / 26 Hwy MPG
    • Lindsay Lexus of Alexandria (393 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Alexandria, VA / 393 miles away from Columbia, SC

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    22 Combined MPG (19 City/26 Highway)

    Listing Information:

    VIN: 2T2SZMDA5MC261477
    Stock: LP17998
    Certified Pre-Owned: No
    Listed since: 06-12-2025

Showing 568 - 588 out of 3,081 listings

Consumer Reviews for the Lexus RX 350

Read recent reviews for the Lexus RX 350
Overall Consumer Rating
4 out of 5 stars50 Reviews
Write a vehicle reviewSee all 50 reviews
  • 5 star
    (64%)
  • 4 star
    (4%)
  • 3 star
    (12%)
  • 2 star
    (10%)
  • 1 star
    (10%)
5 out of 5 stars

Always go back to a Lexus

Jim R., 10/28/2020
2021 Lexus RX 350 4dr SUV (3.5L 6cyl 8A)
While I’ve only had the car a week now, first impressions have settled in. First, the RX is a noticeable improvement from my 2018 Volvo XC60. It’s quieter, smoother, and much more comfortable. The features I gained over the Volvo are all little things that appeal to me. For example, the electrically adjustable steering wheel as part of the memory seating position. The fact that the seat … adjusts to my driving position when starting and retracts when stopping are features the Volvo lacked. The Mark Levenson sound system is the best I’ve ever heard in any car. The sometimes maligned trackpad is extremely easy to use, just adding to the excellent user interface overall. I expected the RX to be quiet and it doesn’t disappoint. The ride is so smooth that I deliberately drove over a small section of a local road that is just a mess of badly done patchwork. The Volvo felt like a stagecoach over this small section, the RX is like a pillow top mattress over the same section. The 20” Michelin tires add to the comfort. My RX included the luxury package, heads up display, heated and cooled seats, triple beam LED headlights, panoramic moonroof and leather upholstery. Overall it is well put together package with more than enough luxury features for what I wanted without the price of the German cars. This is the fourth Lexus over many years, I always seem to come back the brand.
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Used 2021 Lexus RX 350 in Columbia, SC Values

Estimated values
2021 Lexus RX 350 F SPORT 4dr SUV AWD w/Handling Package (3.5L 6cyl 8A) with no options
ConditionTrade-InPrivate PartyDealer Retail
Outstanding$32,104$34,377$36,654
Clean$31,602$33,831$36,062
Average$30,766$32,921$35,076
Rough$29,680$31,739$33,795

The average list price of a used 2021 Lexus RX 350 in Columbia, South Carolina is $39,588. The average mileage on a used Lexus RX 350 2021 for sale in Columbia, South Carolina is 54,901. Based on the average mileage of 54,901 for used 2021 Lexus RX 350 for sale in Columbia, SC and using an average vehicle condition rating, which means the vehicle may have a few mechanical and/or cosmetic problems and may require a considerable amount of reconditioning, we appraise the average trade-in value of a used Lexus RX 350 2021 in Columbia, South Carolina to be $30,766.

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