Skip to main content
Skip to Filters
246 listings
  • New Listing
    Stock photo**
    • 28,483 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Lexus of Wesley Chapel (405 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Wesley Chapel, FL / 405 miles away from Columbia, SC

    F Sport Handling PackageMark Levinson Upgraded AudioPanorama SunroofCARFAX One-Owner. Clean CARFAX. Certified. Ultra White 2022 Lexus RX 450h F Sport ...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2YGMDA1NC085531
    Stock: T085531
    Certified Pre-Owned: Yes
    Listed since: 08-30-2025

  • New Listing
    • 28,015 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Driveway (In-stock online)
    • Home delivery*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Sunroof/Moonroof
    • Keyless Entry/Start
    Close

    Located in Ramsey, NJ / 617 miles away from Columbia, SC

    CarFax No Accidents Reported,CarFax 1-Owner,Low Mileage,Rare Find,Green Vehicle,Apple CarPlay,Back-Up Camera,Blind Spot Monitor,Bluetooth,Brake Assist...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA6LC054353
    Stock: L17916T
    Certified Pre-Owned: No

    • 40,849 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Beyer Subaru of Alexandria (396 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Alexandria, VA / 396 miles away from Columbia, SC

    Clean CARFAX. CARFAX One-Owner.2022 Lexus RX 450h 3.5L V6 DOHC VVT-i 24V AWD eCVT Silver VOLVO OF FALLS CHURCH!!!, Bluetooth Hands Free w/ Audio Strea...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA6NC080521
    Stock: E23379G
    Certified Pre-Owned: No
    Listed since: 08-12-2025

    • 52,447 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • CarMax (In-stock online)
    • Transfer available from CO to SC*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    Close

    Located in Littleton, CO / 1,378 miles away from Columbia, SC

    CarMax values transparency and wants you to love your next car, not settle on it. Certain vehicles may have unrepaired safety recalls. Check nhtsa.gov...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA2LC049067
    Stock: 27736182
    Certified Pre-Owned: No

  • New Listing
    • 16,924 miles
    • 5 Seats, 31 City / 28 Hwy MPG
    • CarMax Ocala (342 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Ocola, FL / 342 miles away from Columbia, SC

    CarMax values transparency and wants you to love your next car, not settle on it. Certain vehicles may have unrepaired safety recalls. Check nhtsa.gov...

    AutoCheck Vehicle History Summary Unavailable.

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA7NC084481
    Stock: 27496594
    Certified Pre-Owned: No

    • 80,099 miles
    • No accidents, 2 owners, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Priority Lexus Virginia Beach (339 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Leather Seats
    Close

    Located in Virginia Beach, VA / 339 miles away from Columbia, SC

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2BGMCA2JC022505
    Stock: 25LV38801
    Certified Pre-Owned: No
    Listed since: 08-28-2025

  • Price Drop
    Stock photo**
    • 62,084 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Brewer Airport Toyota (453 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Moon Township, PA / 453 miles away from Columbia, SC

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA5LC056529
    Stock: LC056529
    Certified Pre-Owned: No
    Listed since: 08-26-2025

  • Stock photo**
    • Not provided
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Ourisman Lexus of Rockville (414 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Rockville, MD / 414 miles away from Columbia, SC

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2YGMDA0NC084371
    Stock: 084371
    Certified Pre-Owned: No
    Listed since: 03-19-2025

    • 83,130 miles
    • 1 accident, 1 owner, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Merlex Auto Group (402 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Arlington, VA / 402 miles away from Columbia, SC

    The 2022 Lexus RX 450h F SPORT Appearance, with 83,130 miles, blends hybrid efficiency, bold styling, and refined comfort into a dynamic luxury SUV pa...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: No

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2SGMDA5NC081794
    Stock: 081794
    Certified Pre-Owned: No
    Listed since: 08-07-2025

    • 49,378 miles
    • Frame damage reported, 2 owners, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Alpha Motor Sports (356 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Sunroof/Moonroof
    • Keyless Entry/Start
    Close

    Located in Fredericksburg, VA / 356 miles away from Columbia, SC

    ** OVER 30,000 VEHICLES SOLD, TWO LOCATION TO SERVE YOU, 400+ VEHICLES IN STOCK, visit www.AlphaMS.com to view our inventory, BEST PRICES IN TOWN **NA...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: No

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Issue reported

    Salvage Vehicle: No

    Frame Damage: Yes

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA5NC088755
    Stock: S088755
    Certified Pre-Owned: No

  • Price Drop
    $41,425
    great price
    $6,306 below market
    • 32,336 miles
    • No accidents, 1 owner, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Find Your Ride Columbus (427 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Columbus, OH / 427 miles away from Columbia, SC

    AWD Automatic 3.5L V6 DOHC VVT-i 24V Clean CARFAX. 2021 Lexus RX 450hAwards: * JD Power Initial Quality Study (IQS) * ALG Residual Value Awards, Resid...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2JGMDA5MC066285
    Stock: WI2T2JGM
    Certified Pre-Owned: No
    Listed since: 08-24-2025

  • Price Drop
    $20,995
    great price
    $2,405 below market
    • 134,919 miles
    • No accidents, 2 owners, corporate fleet vehicle
    • 5 Seats, 31 City / 28 Hwy MPG
    • Wholesale Direct Motors (435 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Leather Seats
    Close

    Located in Dayton, OH / 435 miles away from Columbia, SC

    WE HAVE GUARANTEED FINANCING AND WARRANTIES AVAILABLE ON ALL CARS. SPEAK TO YOUR SALESPERSON FOR COMPLETE DETAILS. PRICES LISTED ARE CASH PRICES. BY F...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: No

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2BGMCA7HC010327
    Stock: 010327
    Certified Pre-Owned: No
    Listed since: 12-03-2024

  • New Listing
    • 34,762 miles
    • 5 Seats, 31 City / 28 Hwy MPG
    • CarMax (In-stock online)
    • Transfer available from TX to SC*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Amarillo, TX / 1,192 miles away from Columbia, SC

    CarMax values transparency and wants you to love your next car, not settle on it. Certain vehicles may have unrepaired safety recalls. Check nhtsa.gov...

    AutoCheck Vehicle History Summary Unavailable.

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2YGMDA9MC060505
    Stock: 26477403
    Certified Pre-Owned: No

  • New Listing
    $40,998
    great price
    $4,788 below market
    • 49,914 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • CarMax (In-stock online)
    • Transfer available from AZ to SC*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Gilbert, AZ / 1,763 miles away from Columbia, SC

    CarMax values transparency and wants you to love your next car, not settle on it. Certain vehicles may have unrepaired safety recalls. Check nhtsa.gov...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2JGMDA1MC064694
    Stock: 27621349
    Certified Pre-Owned: No

    • 87,618 miles
    • 2 accidents, 4 owners, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • CarMax (In-stock online)
    • Transfer available from TX to SC*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Leather Seats
    Close

    Located in San Antonio, TX / 1,074 miles away from Columbia, SC

    CarMax values transparency and wants you to love your next car, not settle on it. Certain vehicles may have unrepaired safety recalls. Check nhtsa.gov...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: No

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2BGMCA0HC009410
    Stock: 27163319
    Certified Pre-Owned: No

  • $20,450
    great price
    $1,917 below market
    • 126,123 miles
    • 1 accident, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Car Source (423 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Leather Seats
    Close

    Located in Grove City, OH / 423 miles away from Columbia, SC

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: No

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2BGMCA6HC020119
    Stock: 61540
    Certified Pre-Owned: No
    Listed since: 06-12-2025

  • Price Drop
    $15,741
    good price
    $1,067 below market
    • 137,854 miles
    • No accidents, 4 owners, personal use
    • 5 Seats, 32 City / 28 Hwy MPG
    • Crossroads Ford (122 mi away)
    • Back-up camera
    • Bluetooth
    • Power Driver Seat
    • Tire Pressure Warnin...
    • USB Inputs
    Close

    Located in Southern Pines, NC / 122 miles away from Columbia, SC

    Clean Carfax, Local Trade, Leather, Power Tailgate, Dual Zone A/C, Heated and Cooled Seats, Sunroof, Cruise Control, Fully Automatic Headlights, Remot...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (32 City/28 Highway)

    Listing Information:

    VIN: 2T2ZB1BAXFC004693
    Stock: PU0430A
    Certified Pre-Owned: No
    Listed since: 08-09-2025

    • 87,918 miles
    • 1 accident, 1 owner, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Zeke's Automotive Group (341 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Smyrna, TN / 341 miles away from Columbia, SC

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: No

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2YGMDAXNC090081
    Stock: 090081
    Certified Pre-Owned: No

  • $30,612
    good price
    $2,129 below market
    • 81,823 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Greensboro Chrysler Dodge Jeep Ram (158 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Greensboro, NC / 158 miles away from Columbia, SC

    2021 Lexus RX 450h**Great Fuel Economy**, **WE DELIVER ANYWHERE**, 3.5L V6 DOHC VVT-i 24V, AWD, Glazed Caramel Artificial Leather.Priced below KBB Fai...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA9MC063095
    Stock: AMC063095
    Certified Pre-Owned: No
    Listed since: 11-25-2024

  • $17,093
    good price
    $1,225 below market
    • 92,464 miles
    • 1 accident, 4 owners, corporate fleet vehicle
    • 5 Seats, 32 City / 28 Hwy MPG
    • Richard Kay Superstore (104 mi away)
    • Back-up camera
    • Bluetooth
    • Navigation
    • Leather Seats
    • Sunroof/Moonroof
    Close

    Located in Anderson, SC / 104 miles away from Columbia, SC

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: No

    Personal Use Only: No

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (32 City/28 Highway)

    Listing Information:

    VIN: 2T2ZB1BA3FC005099
    Stock: P203554D
    Certified Pre-Owned: No
    Listed since: 07-12-2025

  • New Listing
    • 108,400 miles
    • 1 accident, 4 owners, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • CarMax (In-stock online)
    • Transfer available from TX to SC*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Leather Seats
    Close

    Located in Houston, TX / 886 miles away from Columbia, SC

    CarMax values transparency and wants you to love your next car, not settle on it. Certain vehicles may have unrepaired safety recalls. Check nhtsa.gov...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: No

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2BGMCA5HC016319
    Stock: 27613771
    Certified Pre-Owned: No

Showing 85 - 105 out of 246 listings

Consumer Reviews for the Lexus RX 450h

Read recent reviews for the Lexus RX 450h
Overall Consumer Rating
4.4 out of 5 stars35 Reviews
Write a vehicle reviewSee all 35 reviews
  • 5 star
    (69%)
  • 4 star
    (11%)
  • 3 star
    (11%)
  • 2 star
    (6%)
  • 1 star
    (3%)
5 out of 5 stars

Best Family SUV for the Money

Emre Afsar, 08/09/2018
2018 Lexus RX 450h 4dr SUV AWD (3.5L 6cyl gas/electric hybrid CVT)
I am an enthusiast and shopped for months for a larger family SUV. In terms of comfort, space, and fuel economy there is nothing in the market that comes close to the RX 450h. It feels solid and substantial behind the wheel. Effortless steering and acceleration, great visibility thanks to the A pillar and side mirror design. Whisper quiet at any speed and the hybrid powertrain works … seamlessly. Definitely go with the upgraded 12.3 inch infotainment system as it has better input method with the joystick (as oppose to the wheel controller on the base system) and the definition of the screen is very high. Averaging 32 MPG on our first tank so far with the AC on all the time. Speaking of which it is the best AC system I have experienced in any car. Works in conjunction with the heated/ventilated seats and cools the cabin incredibly fast and works super quiet. No negatives or complaints so far, an excellent luxury mid-size SUV. Highly recommended!
Report abuse

Used 2022 Lexus RX 450h in Columbia, SC Values

Estimated values
2022 Lexus RX 450h F SPORT Handling 4dr SUV AWD (3.5L 6cyl gas/electric hybrid CVT) with no options
ConditionTrade-InPrivate PartyDealer Retail
Outstanding$37,195$39,201$41,292
Clean$36,700$38,658$40,699
Average$35,874$37,753$39,709
Rough$34,800$36,576$38,423

The average list price of a used 2022 Lexus RX 450h in Columbia, South Carolina is $34,612. The average mileage on a used Lexus RX 450h 2022 for sale in Columbia, South Carolina is 67,407. Based on the average mileage of 67,407 for used 2022 Lexus RX 450h for sale in Columbia, SC and using an average vehicle condition rating, which means the vehicle may have a few mechanical and/or cosmetic problems and may require a considerable amount of reconditioning, we appraise the average trade-in value of a used Lexus RX 450h 2022 in Columbia, South Carolina to be $35,874.

Filters
Skip to Results

Applied Filters4Active

Select Buying Experience

Location

Search radius500 miles
Search radius

Make & Model

Year

New / Used

Price & Payments

Price Rating

Body Type

Trim

Mileage

Accidents & History

Engine & Drivetrain

Exterior Color

Interior Color

Total Seating

Edmunds Review

Features

Options & Packages

MPG

Listing Details


* Delivery of any kind does not apply to Alaska and Hawaii. Contact the dealer for delivery details, restrictions and costs.