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  • New Listing
    Stock photo**
    • Exterior color: Ultra WhiteUltra White
    • Interior color: Birch leatheretteBirch leatherette
    • 5 Seats, 21 City / 28 Hwy MPG
    • Lexus of Wesley Chapel (436 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Sunroof/Moonroof
    • Keyless Entry/Start
    Close

    Located in Wesley Chapel, FL / 436 miles away from Myrtle Beach, SC

    PackagesP K3 Illuminated Door/Cargo SillsP Z1 Carpet Cargo Mat/Cargo Net/Key Gloves/Wheel LocksAccessoriesF CP Convenience Package: Panoramic View Mon...

    Features and Specs:

    24 Combined MPG (21 City/28 Highway)

    Listing Information:

    VIN: 2T2BAMCAXSC120846
    Stock: L120846
    Listed since: 09-17-2025

  • Stock photo**
    • Exterior color: Cloudburst GrayCloudburst Gray
    • Interior color: Black premium leatherBlack premium leather
    • 5 Seats, 22 City / 29 Hwy MPG
    • Lexus of Wesley Chapel (436 mi away)
    • Back-up camera
    • Bluetooth
    • Leather Seats
    • Sunroof/Moonroof
    • Keyless Entry/Start
    Close

    Located in Wesley Chapel, FL / 436 miles away from Myrtle Beach, SC

    PackagesAccessoriesF CP Convenience Package: Panoramic View Monitor, Advanced Park; Traffic Jam Assist (Requires Drive Connect Subscription; 3-Year Tr...

    Features and Specs:

    25 Combined MPG (22 City/29 Highway)

    Listing Information:

    VIN: 2T2BAMBA9SC067963
    Stock: L067963
    Listed since: 09-12-2025

  • New Listing
    Stock photo**
    • Exterior color: Ultra WhiteUltra White
    • Interior color: Black leatheretteBlack leatherette
    • 5 Seats, 21 City / 28 Hwy MPG
    • Lexus of Wesley Chapel (436 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Sunroof/Moonroof
    • Keyless Entry/Start
    Close

    Located in Wesley Chapel, FL / 436 miles away from Myrtle Beach, SC

    PackagesP K3 Illuminated Door/Cargo SillsP Z1 Carpet Cargo Mat/Cargo Net/Key Gloves/Wheel LocksAccessoriesF CP Convenience Package: Panoramic View Mon...

    Features and Specs:

    24 Combined MPG (21 City/28 Highway)

    Listing Information:

    VIN: 2T2BAMCA7SC121288
    Stock: L121288
    Listed since: 09-19-2025

    • Exterior color: IridiumIridium
    • Interior color: Palomino leatherettePalomino leatherette
    • 5 Seats, 22 City / 29 Hwy MPG
    • Lexus of Wesley Chapel (436 mi away)
    • Back-up camera
    • Bluetooth
    • Sunroof/Moonroof
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Wesley Chapel, FL / 436 miles away from Myrtle Beach, SC

    PackagesP 2T All Weather Floor Liner, All Weather Cargo MatAccessoriesF DK Digital Key (Requires Remote Connect Subscription; 3YR Trial Incld). 4G Net...

    Features and Specs:

    25 Combined MPG (22 City/29 Highway)

    Listing Information:

    VIN: JTJCHMAA1S2032903
    Stock: L032903A
    Listed since: 09-13-2025

  • New Listing
    Stock photo**
    • Exterior color: Cloudburst GrayCloudburst Gray
    • Interior color: Palomino leatherettePalomino leatherette
    • 5 Seats, 22 City / 29 Hwy MPG
    • Lexus of Wesley Chapel (436 mi away)
    • Back-up camera
    • Bluetooth
    • Sunroof/Moonroof
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Wesley Chapel, FL / 436 miles away from Myrtle Beach, SC

    PackagesP 2T All Weather Floor Liner, All Weather Cargo MatAccessoriesF DK Digital Key (Requires Remote Connect Subscription; 3YR Trial Incld). 4G Net...

    Features and Specs:

    25 Combined MPG (22 City/29 Highway)

    Listing Information:

    VIN: JTJCHMAA8S2032882
    Stock: L032882A
    Listed since: 09-17-2025

  • New Listing
    Stock photo**
    $58,435
    MSRP $58,435
    • Exterior color: CaviarCaviar
    • Interior color: Palomino leatherettePalomino leatherette
    • 5 Seats, 22 City / 29 Hwy MPG
    • Lexus of Wesley Chapel (436 mi away)
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    • Blind Spot Monitorin...
    Close

    Located in Wesley Chapel, FL / 436 miles away from Myrtle Beach, SC

    PackagesP 2T All Weather Floor Liner, All Weather Cargo MatAccessoriesF DK Digital Key (Requires Remote Connect Subscription; 3YR Trial Incld). 4G Net...

    Features and Specs:

    25 Combined MPG (22 City/29 Highway)

    Listing Information:

    VIN: JTJCHMAA0S2032908
    Stock: L032908
    Listed since: 09-18-2025

  • Stock photo**
    • Exterior color: Copper CrestCopper Crest
    • Interior color: Palomino leatherettePalomino leatherette
    • 5 Seats, 22 City / 29 Hwy MPG
    • Lexus of Wesley Chapel (436 mi away)
    • Back-up camera
    • Bluetooth
    • Sunroof/Moonroof
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Wesley Chapel, FL / 436 miles away from Myrtle Beach, SC

    PackagesP 2T All Weather Floor Liner, All Weather Cargo MatAccessoriesF DK Digital Key (Requires Remote Connect Subscription; 3YR Trial Incld). 4G Net...

    Features and Specs:

    25 Combined MPG (22 City/29 Highway)

    Listing Information:

    VIN: JTJCHMAA7S2033053
    Stock: L033053A
    Listed since: 09-13-2025

  • New Listing
    Stock photo**
    • Exterior color: Copper CrestCopper Crest
    • Interior color: Palomino leatherettePalomino leatherette
    • 5 Seats, 37 City / 34 Hwy MPG
    • Lexus of Wesley Chapel (436 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Sunroof/Moonroof
    • Keyless Entry/Start
    Close

    Located in Wesley Chapel, FL / 436 miles away from Myrtle Beach, SC

    PackagesAccessoriesF DK Digital Key (Requires Remote Connect Subscription; 3YR Trial Incld). 4G Network Dependent.F NW Lexus Interface with 14-in Touc...

    Features and Specs:

    36 Combined MPG (37 City/34 Highway)

    Listing Information:

    VIN: 2T2BBMCA9SC100925
    Stock: L100925
    Listed since: 09-21-2025

    • Exterior color: IridiumIridium
    • Interior color: Birch leatherBirch leather
    • 5 Seats, 22 City / 29 Hwy MPG
    • Lexus of Wesley Chapel (436 mi away)
    • Back-up camera
    • Bluetooth
    • Leather Seats
    • Sunroof/Moonroof
    • Keyless Entry/Start
    Close

    Located in Wesley Chapel, FL / 436 miles away from Myrtle Beach, SC

    PackagesP 2T All Weather Floor Liner, All Weather Cargo MatP Z1 Carpet Cargo Mat/Cargo Net/Key Gloves/Wheel LocksAccessoriesF DK Digital Key (Requires...

    Features and Specs:

    25 Combined MPG (22 City/29 Highway)

    Listing Information:

    VIN: JTJCHMAAXS2030471
    Stock: L030471
    Listed since: 08-07-2025

  • $51,860
    MSRP $51,860
    • Exterior color: Eminent White PearlEminent White Pearl
    • Interior color: Black leatheretteBlack leatherette
    • 5 Seats, 22 City / 29 Hwy MPG
    • Lexus of Wesley Chapel (436 mi away)
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    • Blind Spot Monitorin...
    Close

    Located in Wesley Chapel, FL / 436 miles away from Myrtle Beach, SC

    AccessoriesF PJ Premium PaintF TP Technology Package: Wireless Phone Charger; Digital Key (Requires Remote Connect Subscription; 3-Year Trial Included...

    Features and Specs:

    25 Combined MPG (22 City/29 Highway)

    Listing Information:

    VIN: 2T2BAMBAXSC067115
    Stock: L067115
    Listed since: 08-09-2025

    • Exterior color: IridiumIridium
    • Interior color: Black leatheretteBlack leatherette
    • 5 Seats, 22 City / 29 Hwy MPG
    • Lexus of Wesley Chapel (436 mi away)
    • Back-up camera
    • Bluetooth
    • Sunroof/Moonroof
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Wesley Chapel, FL / 436 miles away from Myrtle Beach, SC

    PackagesP 2T All Weather Floor Liner, All Weather Cargo MatAccessoriesF DK Digital Key (Requires Remote Connect Subscription; 3YR Trial Incld). 4G Net...

    Features and Specs:

    25 Combined MPG (22 City/29 Highway)

    Listing Information:

    VIN: JTJCHMAA6S2032671
    Stock: L032671
    Listed since: 09-06-2025

  • Stock photo**
    • Exterior color: Cloudburst GrayCloudburst Gray
    • Interior color: Macadamia leatherMacadamia leather
    • 5 Seats, 21 City / 28 Hwy MPG
    • Lexus of Wesley Chapel (436 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Leather Seats
    • Sunroof/Moonroof
    Close

    Located in Wesley Chapel, FL / 436 miles away from Myrtle Beach, SC

    PackagesP K3 Illuminated Door/Cargo SillsP Z1 Carpet Cargo Mat/Cargo Net/Key Gloves/Wheel LocksAccessoriesF CP Convenience Package: Panoramic View Mon...

    Features and Specs:

    24 Combined MPG (21 City/28 Highway)

    Listing Information:

    VIN: 2T2BAMCA6SC120259
    Stock: L120259
    Listed since: 09-11-2025

  • Stock photo**
    • Exterior color: Nightfall MicaNightfall Mica
    • Interior color: Palomino leatherettePalomino leatherette
    • 5 Seats, 22 City / 29 Hwy MPG
    • Lexus of Wesley Chapel (436 mi away)
    • Back-up camera
    • Bluetooth
    • Sunroof/Moonroof
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Wesley Chapel, FL / 436 miles away from Myrtle Beach, SC

    PackagesP 2T All Weather Floor Liner, All Weather Cargo MatAccessoriesF DK Digital Key (Requires Remote Connect Subscription; 3YR Trial Incld). 4G Net...

    Features and Specs:

    25 Combined MPG (22 City/29 Highway)

    Listing Information:

    VIN: JTJCHMAA3S2032708
    Stock: L032708
    Listed since: 09-05-2025

    • Exterior color: IridiumIridium
    • Interior color: Black leatheretteBlack leatherette
    • 5 Seats, 22 City / 29 Hwy MPG
    • Lexus of Wesley Chapel (436 mi away)
    • Back-up camera
    • Bluetooth
    • Sunroof/Moonroof
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Wesley Chapel, FL / 436 miles away from Myrtle Beach, SC

    PackagesP 2T All Weather Floor Liner, All Weather Cargo MatAccessoriesF DK Digital Key (Requires Remote Connect Subscription; 3YR Trial Incld). 4G Net...

    Features and Specs:

    25 Combined MPG (22 City/29 Highway)

    Listing Information:

    VIN: JTJCHMAA4S2033060
    Stock: L033060
    Listed since: 09-13-2025

  • New Listing
    Stock photo**
    • Exterior color: Cloudburst GrayCloudburst Gray
    • Interior color: Birch leatherBirch leather
    • 5 Seats, 22 City / 29 Hwy MPG
    • Lexus of Wesley Chapel (436 mi away)
    • Back-up camera
    • Bluetooth
    • Leather Seats
    • Sunroof/Moonroof
    • Keyless Entry/Start
    Close

    Located in Wesley Chapel, FL / 436 miles away from Myrtle Beach, SC

    PackagesP K3 Illuminated Door/Cargo SillsP Z1 Carpet Cargo Mat/Cargo Net/Key Gloves/Wheel LocksAccessoriesF CP Convenience Package: Panoramic View Mon...

    Features and Specs:

    25 Combined MPG (22 City/29 Highway)

    Listing Information:

    VIN: 2T2BAMBA9SC068367
    Stock: L068367
    Listed since: 09-19-2025

  • New Listing
    • Exterior color: Cloudburst GrayCloudburst Gray
    • Interior color: Palomino leatherettePalomino leatherette
    • 5 Seats, 22 City / 29 Hwy MPG
    • Lexus of Wesley Chapel (436 mi away)
    • Back-up camera
    • Bluetooth
    • Sunroof/Moonroof
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Wesley Chapel, FL / 436 miles away from Myrtle Beach, SC

    PackagesP 2T All Weather Floor Liner, All Weather Cargo MatAccessoriesF DK Digital Key (Requires Remote Connect Subscription; 3YR Trial Incld). 4G Net...

    Features and Specs:

    25 Combined MPG (22 City/29 Highway)

    Listing Information:

    VIN: JTJCHMAA1S2032464
    Stock: L032464
    Listed since: 09-21-2025

  • Arriving Soon
    • Exterior color: Nightfall MicaNightfall Mica
    • Interior color: Macadamia premium leatherMacadamia premium leather
    • 5 Seats, 21 City / 28 Hwy MPG
    • Lexus of Wilmington (451 mi away)4.2 out of 5 stars(5)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Leather Seats
    • Sunroof/Moonroof
    Close

    Located in Wilmington, DE / 451 miles away from Myrtle Beach, SC

    AWD, Macadamia W/Ash Bamboo Se. 2025 Lexus RX 350 Luxury 350 Luxury Mica 2.4L I4 Turbo 21/28 City/Highway MPG 8-Speed Automatic 21/28 City/Highway MPG...

    Features and Specs:

    24 Combined MPG (21 City/28 Highway)

    Listing Information:

    VIN: 2T2BAMCA1SC122517
    Stock: R5122517
    Listed since: 09-17-2025

    • Exterior color: Nightfall MicaNightfall Mica
    • Interior color: Black premium leatherBlack premium leather
    • 5 Seats, 21 City / 28 Hwy MPG
    • Lexus of Wilmington (451 mi away)4.2 out of 5 stars(5)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Leather Seats
    • Sunroof/Moonroof
    Close

    Located in Wilmington, DE / 451 miles away from Myrtle Beach, SC

    AWD, 21. 2025 Lexus RX 350 Luxury 350 Luxury Mica 2.4L I4 Turbo 21/28 City/Highway MPG 8-Speed Automatic 21/28 City/Highway MPG *Our Internet Price IN...

    Features and Specs:

    24 Combined MPG (21 City/28 Highway)

    Listing Information:

    VIN: 2T2BAMCA5SC117238
    Stock: R5117238
    Listed since: 08-18-2025

    • Exterior color: IridiumIridium
    • Interior color: Black premium leatherBlack premium leather
    • 5 Seats, 21 City / 28 Hwy MPG
    • Lexus of Wilmington (451 mi away)4.2 out of 5 stars(5)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Leather Seats
    • Sunroof/Moonroof
    Close

    Located in Wilmington, DE / 451 miles away from Myrtle Beach, SC

    AWD, Blk W/Blk Open Pore Semi. 2025 Lexus RX 350 Luxury 350 Luxury Iridium 2.4L I4 Turbo 21/28 City/Highway MPG 8-Speed Automatic 21/28 City/Highway M...

    Features and Specs:

    24 Combined MPG (21 City/28 Highway)

    Listing Information:

    VIN: 2T2BAMCA1SC121285
    Stock: R5121285
    Listed since: 09-16-2025

  • Arriving Soon
    • Exterior color: Nightfall MicaNightfall Mica
    • Interior color: Black premium leatherBlack premium leather
    • 5 Seats, 21 City / 28 Hwy MPG
    • Lexus of Wilmington (451 mi away)4.2 out of 5 stars(5)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Leather Seats
    • Sunroof/Moonroof
    Close

    Located in Wilmington, DE / 451 miles away from Myrtle Beach, SC

    AWD, Peppercorn W/Blk Semi-Ani. 2025 Lexus RX 350 Luxury 350 Luxury Mica 2.4L I4 Turbo 21/28 City/Highway MPG 8-Speed Automatic 21/28 City/Highway MPG...

    Features and Specs:

    24 Combined MPG (21 City/28 Highway)

    Listing Information:

    VIN: 2T2BAMCA9SC122751
    Stock: R5122751
    Listed since: 09-19-2025

    • Exterior color: Matador Red MicaMatador Red Mica
    • Interior color: Birch leatheretteBirch leatherette
    • 5 Seats, 21 City / 28 Hwy MPG
    • Lexus of Wilmington (451 mi away)4.2 out of 5 stars(5)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Sunroof/Moonroof
    • Keyless Entry/Start
    Close

    Located in Wilmington, DE / 451 miles away from Myrtle Beach, SC

    AWD, Birch W/Blk Open Pore Nul Artificial Leather. 2025 Lexus RX 350 Premium 350 Premium Matador Red 2.4L I4 Turbo 21/28 City/Highway MPG 8-Speed Auto...

    Features and Specs:

    24 Combined MPG (21 City/28 Highway)

    Listing Information:

    VIN: 2T2BAMCA4SC119451
    Stock: R5119451
    Listed since: 09-03-2025

Showing 316 - 336 out of 3,784 listings
TrimMPGEngineStarting Price
2025 Lexus RX 350 F SPORT Design 4dr SUV AWD (2.4L 4cyl Turbo 8A)21 - 284-cylinders (gas)$61,919
2025 Lexus RX 350 Luxury 4dr SUV (2.4L 4cyl Turbo 8A)22 - 294-cylinders (gas)$65,760
2025 Lexus RX 350 Premium 4dr SUV (2.4L 4cyl Turbo 8A)22 - 294-cylinders (gas)$56,050
2025 Lexus RX 350 4dr SUV (2.4L 4cyl Turbo 8A)22 - 294-cylinders (gas)$51,860
2025 Lexus RX 350h Premium 4dr SUV AWD (2.5L 4cyl gas/electric hybrid CVT)37 - 344-cylinders (hybrid)$57,685
2025 Lexus RX 350 Premium Plus 4dr SUV (2.4L 4cyl Turbo 8A)22 - 294-cylinders (gas)$59,184
2025 Lexus RX 350 Premium Plus 4dr SUV AWD (2.4L 4cyl Turbo 8A)21 - 284-cylinders (gas)$63,324
2025 Lexus RX 350 Luxury 4dr SUV AWD (2.4L 4cyl Turbo 8A)21 - 284-cylinders (gas)$67,544
2025 Lexus RX 350 Premium 4dr SUV AWD (2.4L 4cyl Turbo 8A)21 - 284-cylinders (gas)$57,725

More about the Lexus RX

Edmunds has 3,784 New Lexus RXes for sale near you, including a 2025 RX 350 SUV and a 2025 RX 350 Luxury SUV ranging in price from $51,860 to $68,559.

How much is a new 2025 Lexus RX in Myrtle Beach, SC?

A new 2025 Lexus RX starts at $51,860 (including destination charge) in Myrtle Beach, SC. Prices will go up based on the trim level you choose and any options you add. Keep in mind that prices can also vary from one state to another and even from one dealership to the next.

How much does a 2025 Lexus RX SUV cost in Myrtle Beach, SC?

A new 2025 Lexus RX SUV starts at $51,860 in Myrtle Beach, SC. Prices will vary depending on what trim level you choose. Each state may have different pricing, so make sure you enter your correct ZIP code on Edmunds.
Other versions include:
2025 Lexus RX Hybrid which starts at $57,685.
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