Skip to FiltersReport abuse
571 listings
- Arriving Soon$53,668MSRP $53,668
- Exterior color: CaviarCaviar
- Interior color: Circuit Red leatheretteCircuit Red leatherette
- 19 City / 26 Hwy MPG
- Mungenast Lexus of St Louis (103 mi away)(8)
Close
Located in Manchester, MO / 103 miles away from Cape Girardeau, MO
Caviar 2025 Lexus IS 350 F SPORT AWD 6-Speed Automatic 3.5L V6 DOHC Dual VVT-i 24V 19/26 City/Highway MPG
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: JTHGZ1E21S5042010
Stock: 35618
Listed since: 08-02-2025 - Arriving Soon$58,980MSRP $58,980
- Exterior color: IncognitoIncognito
- Interior color: White leatheretteWhite leatherette
- 19 City / 26 Hwy MPG
- Reliable Lexus (203 mi away)
Close
Located in Springfield, MO / 203 miles away from Cape Girardeau, MO
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: JTHGZ1E23S5041375
Stock: 041375
Listed since: 08-01-2025 - $51,289MSRP
- Exterior color: Ultra WhiteUltra White
- Interior color: Glazed Caramel leatheretteGlazed Caramel leatherette
- 19 City / 26 Hwy MPG
- Lexus of Merrillville (310 mi away)(2)
Close
Located in Merrillville, IN / 310 miles away from Cape Girardeau, MO
0083 2025 Lexus IS 350 F SPORT Design AWD 6-Speed Automatic 3.5L V6 DOHC Dual VVT-i 24VRecent Arrival! 19/26 City/Highway MPG
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: JTHBZ1E24S5041458
Stock: LM0608
Listed since: 08-28-2025 - $51,008MSRP
- Exterior color: IncognitoIncognito
- Interior color: Black leatheretteBlack leatherette
- 19 City / 26 Hwy MPG
- Lexus of Orland (311 mi away)(1)
Close
Located in Orland Park, IL / 311 miles away from Cape Girardeau, MO
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: JTHBZ1E26S5041610
Stock: LX0985
Listed since: 08-28-2025 - Arriving Soon$68,953MSRP
- Exterior color: CaviarCaviar
- Interior color: Circuit Red leatheretteCircuit Red leatherette
- 17 City / 25 Hwy MPG
- Lexus of Knoxville (315 mi away)
Close
Located in Knoxville, TN / 315 miles away from Cape Girardeau, MO
Caviar 2025 Lexus IS 500 F SPORT Performance Premium RWD 8-Speed Automatic 5.0L V8 DOHC 32V **FULLY SERVICED BY A FACTORY TRAINED TECHNICIAN.
Features and Specs:
20 Combined MPG (17 City/25 Highway)
Listing Information:
VIN: JTHAP1D26S5008139
Stock: 2621
Listed since: 07-25-2025 - Arriving Soon$47,379MSRP
- Exterior color: Cloudburst GrayCloudburst Gray
- Interior color: Black leatheretteBlack leatherette
- 20 City / 28 Hwy MPG
- Lexus of Knoxville (315 mi away)
Close
Located in Knoxville, TN / 315 miles away from Cape Girardeau, MO
Gray 2025 Lexus IS 350 F SPORT Design RWD 8-Speed Automatic 3.5L V6 DOHC Dual VVT-i 24V **FULLY SERVICED BY A FACTORY TRAINED TECHNICIAN.Recent Arriva...
Features and Specs:
23 Combined MPG (20 City/28 Highway)
Listing Information:
VIN: JTHBZ1B20S5089740
Stock: 2598
Listed since: 08-19-2025 - $51,313MSRP $51,313
- Exterior color: Ultrasonic Blue Mica 2.0Ultrasonic Blue Mica 2.0
- Interior color: Glazed Caramel leatheretteGlazed Caramel leatherette
- 19 City / 26 Hwy MPG
- McGrath Lexus of Chicago (334 mi away)
Close
Located in Chicago, IL / 334 miles away from Cape Girardeau, MO
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: JTHBZ1E25S5041890
Stock: S1696
Listed since: 08-15-2025 - New Listing$59,708MSRP $59,708
- Exterior color: IncognitoIncognito
- Interior color: White leatheretteWhite leatherette
- 19 City / 26 Hwy MPG
- McGrath Lexus of Chicago (334 mi away)
Close
Located in Chicago, IL / 334 miles away from Cape Girardeau, MO
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: JTHGZ1E2XS5041986
Stock: S1762
Listed since: 09-02-2025 - $68,998MSRP $68,998
- Exterior color: IncognitoIncognito
- Interior color: Black leatheretteBlack leatherette
- 17 City / 25 Hwy MPG
- McGrath Lexus of Chicago (334 mi away)
Close
Located in Chicago, IL / 334 miles away from Cape Girardeau, MO
Features and Specs:
20 Combined MPG (17 City/25 Highway)
Listing Information:
VIN: JTHAP1D2XS5008094
Stock: S1730
Listed since: 08-25-2025 - $51,008MSRP $51,008
- Exterior color: CaviarCaviar
- Interior color: Rioja Red leatheretteRioja Red leatherette
- 19 City / 26 Hwy MPG
- McGrath Lexus of Chicago (334 mi away)
Close
Located in Chicago, IL / 334 miles away from Cape Girardeau, MO
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: JTHBZ1E23S5041709
Stock: S1665
Listed since: 08-11-2025 - $57,808MSRP $57,808
- Exterior color: Ultra WhiteUltra White
- Interior color: Circuit Red leatheretteCircuit Red leatherette
- 19 City / 26 Hwy MPG
- McGrath Lexus of Chicago (334 mi away)
Close
Located in Chicago, IL / 334 miles away from Cape Girardeau, MO
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: JTHGZ1E29S5041722
Stock: S1679
Listed since: 08-14-2025 - Arriving Soon$50,718MSRP $50,718
- Exterior color: CaviarCaviar
- Interior color: Black leatheretteBlack leatherette
- 19 City / 26 Hwy MPG
- Fields Lexus Glenview (344 mi away)(5)
Close
Located in Glenview, IL / 344 miles away from Cape Girardeau, MO
Caviar 2025 Lexus IS 350 F SPORT Design AWD 6-Speed Automatic 3.5L V6 DOHC Dual VVT-i 24VLexus Glenview is proud to offer this wonderful 2025 Lexus ...
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: JTHBZ1E23S5041760
Stock: L251272
Listed since: 07-23-2025 - $50,755MSRP $50,755
- Exterior color: Ultra WhiteUltra White
- Interior color: Rioja Red leatheretteRioja Red leatherette
- 19 City / 26 Hwy MPG
- Lexus of Arlington (345 mi away)(2)
Close
Located in Arlington Heights, IL / 345 miles away from Cape Girardeau, MO
2025 Lexus IS 350 F SPORT DesignAt Lexus of Arlington, it’s our mission to provide the drivers of Arlington Heights, IL with prestigious, luxury veh...
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: JTHBZ1E22S5041782
Stock: AL4277
Listed since: 08-13-2025 - Arriving Soon$57,505MSRP $57,505
- Exterior color: Ultra WhiteUltra White
- Interior color: Black leatheretteBlack leatherette
- 19 City / 26 Hwy MPG
- Lexus of Arlington (345 mi away)(2)
Close
Located in Arlington Heights, IL / 345 miles away from Cape Girardeau, MO
2025 Lexus IS 350 F SPORTAt Lexus of Arlington, it’s our mission to provide the drivers of Arlington Heights, IL with prestigious, luxury vehicles. ...
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: JTHGZ1E22S5041951
Stock: AL4340
Listed since: 08-29-2025 - Arriving Soon$57,563MSRP $57,563
- Exterior color: Cloudburst GrayCloudburst Gray
- Interior color: Black leatheretteBlack leatherette
- 19 City / 26 Hwy MPG
- Lexus of Arlington (345 mi away)(2)
Close
Located in Arlington Heights, IL / 345 miles away from Cape Girardeau, MO
2025 Lexus IS 350 F SPORTAt Lexus of Arlington, it’s our mission to provide the drivers of Arlington Heights, IL with prestigious, luxury vehicles. ...
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: JTHGZ1E29S5042000
Stock: 3871
Listed since: 08-02-2025 - $69,658MSRP $69,658
- Exterior color: Ultra WhiteUltra White
- Interior color: Circuit Red leatheretteCircuit Red leatherette
- 17 City / 25 Hwy MPG
- Lexus of Highland Park (351 mi away)
Close
Located in Highland Park, IL / 351 miles away from Cape Girardeau, MO
Ultra White 2025 Lexus IS 500 F SPORT Performance RWD 8-Speed Automatic 5.0L V8 DOHC 32VLexus of Highland Park is a truly family-owned and operated...
Features and Specs:
20 Combined MPG (17 City/25 Highway)
Listing Information:
VIN: JTHAP1D29S5008152
Stock: 250966
Listed since: 08-18-2025 - New Listing$51,218MSRP $51,218
- Exterior color: Cloudburst GrayCloudburst Gray
- Interior color: Rioja Red leatheretteRioja Red leatherette
- 19 City / 26 Hwy MPG
- Lexus of Highland Park (351 mi away)
Close
Located in Highland Park, IL / 351 miles away from Cape Girardeau, MO
Gray 2025 Lexus IS 350 F SPORT Design AWD 6-Speed Automatic 3.5L V6 DOHC Dual VVT-i 24VRecent Arrival! 19/26 City/Highway MPGLexus of Highland Pa...
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: JTHBZ1E26S5041963
Stock: 250988
Listed since: 08-29-2025 - New Listing$47,218MSRP $47,218
- Exterior color: Ultra WhiteUltra White
- Interior color: Black leatheretteBlack leatherette
- 20 City / 28 Hwy MPG
- Nalley Lexus Smyrna (369 mi away)
Close
Located in Smyrna, GA / 369 miles away from Cape Girardeau, MO
Ultra White 2025 Lexus IS 350 F SPORT Design RWD 8-Speed Automatic 3.5L V6 DOHC Dual VVT-i 24VRecent Arrival! 20/28 City/Highway MPG
Features and Specs:
23 Combined MPG (20 City/28 Highway)
Listing Information:
VIN: JTHBZ1B28S5089890
Stock: NLS257948
Listed since: 08-28-2025 - New Listing$47,490MSRP $47,490
- Exterior color: Ultrasonic Blue Mica 2.0Ultrasonic Blue Mica 2.0
- Interior color: Black leatheretteBlack leatherette
- 20 City / 28 Hwy MPG
- Butler Lexus of South Atlanta (382 mi away)
Close
Located in Union City, GA / 382 miles away from Cape Girardeau, MO
Features and Specs:
23 Combined MPG (20 City/28 Highway)
Listing Information:
VIN: JTHBZ1B29S5089879
Stock: 5089879
Listed since: 08-27-2025 - $51,943MSRP $51,943
- Exterior color: IncognitoIncognito
- Interior color: White leatheretteWhite leatherette
- 19 City / 26 Hwy MPG
- Germain Lexus of Dublin (398 mi away)(8)
Close
Located in Dublin, OH / 398 miles away from Cape Girardeau, MO
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: JTHGZ1E22S5041271
Stock: 55019
Listed since: 08-12-2025 - New Listing$51,248MSRP $51,248
- Exterior color: Ultra WhiteUltra White
- Interior color: Rioja Red leatheretteRioja Red leatherette
- 19 City / 26 Hwy MPG
- Germain Lexus of Dublin (398 mi away)(8)
Close
Located in Dublin, OH / 398 miles away from Cape Girardeau, MO
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: JTHBZ1E29S5041598
Stock: 55104
Listed since: 08-29-2025
Showing 1 - 21 out of 571 listings
Consumer Reviews for the Lexus IS
Read recent reviews for the Lexus IS
The last of the V8's
HJP, 01/10/2024
2024 Lexus IS 500 F SPORT Performance Premium 4dr Sedan (5.0L 8cyl 8A)
Just purchased a 2024 IS500 vector blue as soon as I saw it at the dealer. Happy to pay MSRP as this will be a classic. The car is fast and fun to drive and unlike a hard core M3 or AMG it is actually very comfortable as a daily driver, and that V8 sound is SPECTACULAR! This is probably the best looking sports sedan in the market. Some reviews complain about a dated interior, however I … find it comfortable and very high quality, in fact that is one of the reasons Lexus and Toyotas are so reliable, they are not constantly making drastic changes every year but constantly improving on what is already a top notch fit and finish. If you live in an area with winter snow and ice this might not be a good year round car and the only other possible issue is the rear seat is tight so if you transport big and tall people keep the ride short.
| Trim | MPG | Engine | Starting Price |
|---|---|---|---|
| 2025 Lexus IS 350 F SPORT 4dr Sedan AWD (3.5L 6cyl 6A) | 19 - 26 | 6-cylinders (gas) | $51,943 |
| 2025 Lexus IS 350 F SPORT Design 4dr Sedan AWD (3.5L 6cyl 6A) | 19 - 26 | 6-cylinders (gas) | $50,718 |
| 2025 Lexus IS 500 F SPORT Performance 4dr Sedan (5.0L 8cyl 8A) | 17 - 25 | 8-cylinders (gas) | $68,953 |
| 2025 Lexus IS 350 F SPORT Design 4dr Sedan (3.5L 6cyl 8A) | 20 - 28 | 6-cylinders (gas) | $47,218 |
More about the Lexus IS
Edmunds has 571 New Lexus ISes for sale near you, including a 2025 IS 350 F SPORT Design Sedan and a 2025 IS 500 F SPORT Performance Sedan ranging in price from $47,218 to $69,658.
How much is a new 2025 Lexus IS in Cape Girardeau, MO?
- A new 2025 Lexus IS starts at $47,218 (including destination charge) in Cape Girardeau, MO. Prices will go up based on the trim level you choose and any options you add. Keep in mind that prices can also vary from one state to another and even from one dealership to the next.
How much does a 2025 Lexus IS Sedan cost in Cape Girardeau, MO?
- A new 2025 Lexus IS Sedan starts at $47,218 in Cape Girardeau, MO. Prices will vary depending on what trim level you choose. Each state may have different pricing, so make sure you enter your correct ZIP code on Edmunds.
Filters
Skip to Results