Used 2006 Mercedes-Benz S-Class S65 AMG

2006 Mercedes-Benz S-Class
List price range


  • Elegantly appointed and spacious cabin, feels nimble for its size, state-of-the-art safety features, strong resale value.


  • Complicated COMAND system, not as athletic as some of its competitors, a few low-grade interior materials.

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Edmunds' Expert Review

The S-Class is a top choice when it comes to a no-compromise, full-size luxury sedan.

vehicle overview

The S-Class is Mercedes' flagship sedan. The current generation, introduced in 2000, brought sleeker styling, more advanced technology and greater performance than the heavier versions that preceded it. Two models were available initially, the S430 and S500 sedans, with V8 engines of 4.3 liters (275 horsepower) and 5.0 liters (302 horses), respectively. Lighter and less expensive than the robust Benz sedans that preceded it, the 2000 S-Class earned praise for its sleek body, exceptional comfort and performance that belied its size. However, it was criticized for overly complex controls, especially the standard COMAND system that operated the navigation and audio systems. Soon after, two more S-Class sedans joined the lineup, the top-dog S600 (with its 362-hp, 5.8-liter V12) and the AMG-tweaked S55 (which had a 5.4-liter, 355-horse V8), making sure both the ultraluxury and ultraluxury/sport sedan markets were covered.

For 2003, Mercedes made a number of significant advances in performance and safety. Responding to the ever-rising performance bar in this class, Mercedes installed a new, more powerful 493-hp V12 in the top-of-the-line S600 and added a supercharger to the S55, also yielding 493 horses albeit less torque. (If that's still not enough for you, Mercedes has slotted an even more powerful S65 AMG model into the lineup for 2006.) Practical technology comes in the form of all-wheel drive, dubbed 4Matic, which is available on the S430 and S500 models. Ideal for those who live in rainy or snowy climates, 4Matic automatically directs power to whichever wheel(s) have the best grip. And at the forefront of safety is the Pre-Safe system, which can sense an imminent accident and automatically tighten the seatbelts and position the power seats to afford the best protection for the occupants. For those who don't need the ultimate in power for their large sedan, Mercedes-Benz introduced the S350 for 2006. This S is powered by a 3.7-liter V6 with 241 hp. Regardless of engine choice, the S-Class is still one of the top sedans in its class and certainly the winner when it comes to curbside prestige.

trim levels & features

The four-door S-Class sedan is available in four models: the S350, S430, S500 and S600. All models come with most of the luxury features you would expect in a sedan of this caliber, including 14-way power-adjustable front seats, a DVD navigation system, Bose premium audio system, and rich leather and wood trim. Notable options include ventilated front seats with a massage feature, a keyless entry and start system (called Keyless Go), adaptive cruise control and a sport package that includes larger wheels and tires, resculpted bumpers and side skirts.

performance & mpg

The entry-level S350 features a 3.7-liter V6 with 241 hp and 258 lb-ft of torque. The S430 is powered by a 4.3-liter, 275-hp V8, while the S500 offers more power courtesy of its 5.0-liter V8 rated for 302 hp. Both V8 engines use a seven-speed automatic transmission, while the V6 uses a five-speed unit. The top-of-the-line S600 uses a twin-turbocharged 5.5-liter V12 rated to produce 493 hp and 590 lb-ft of torque; it's paired with a five-speed automatic. Mercedes claims that the S600 can hit 60 mph in about 4.5 seconds, placing it in a league usually occupied by exotic sports cars. The S430 and S500 are available with either the standard rear-drive setup or the fully automatic 4Matic all-wheel-drive system as a no-cost option. Note that 4Matic-equipped cars use a five-speed automatic instead of the seven-speed.


Every S-Class sedan includes "Pre-Safe," which determines accident probability by using sensors in the stability control and BrakeAssist systems. Should an accident seem unavoidable, the system applies split-second tensioning of the seatbelts, moves the front-passenger seat and power-adjustable rear seats to the most favorable positions and closes the sunroof (if the vehicle is skidding). If the accident is averted at the last moment, the seatbelt tensioning is cancelled and the seats are reset to their original positions. Of course, Pre-Safe joins a list of already impressive safety features that includes four-wheel antilock disc brakes, electronic traction and stability control, seat-mounted side-impact airbags for front occupants and side curtain airbags that protect both front and rear passengers.


The S-Class has that enviable quality of feeling smaller and more nimble than its substantial size suggests. Strong acceleration, precise handling and a relaxing ride remain strong virtues of Mercedes' senior sedan. The S600 provides truly exceptional performance in a straight line, but BMW's 760Li is still a more involving driving experience. Buyers needing all-weather capability should consider the 4Matic versions of the S430 and S500.


Virtually every luxury and convenience item to be found in an automobile, including a DVD-based navigation system and power door-closing assist, is standard on each S-Class sedan. Still, there are optional designo interior trim packages which include more dramatic leather and wood combinations, as well as dynamic multicontour front seats, four-zone climate control and power-adjustable rear seats.

Top consumer reviews

Read what other owners think about the 2006 Mercedes-Benz S-Class.

Best Car I've Ever Driven
Jim, 7/17/2008
Wow! I've driven high performance cars from a Mustang, Porsche, and even Ferrari. This 2006 S65 AMG is an absolute beast on the road. And a classy beast at that. The best way to describe it would be to say it is a rocket! Its super fast from 0-60, and even pulls hard above that! Pure power, smooth acceleration, superb handling and great comfort! If you can find a way to get your hands on one of these babies, its worth every penny (or dollar in this case) I can't wait to drive tomorrow. Sweet!
World's Fastest Production Sedan & Most Versitle
amgfan, 1/27/2014
In 2005-06, this car would do 220+ mph off the showroom floor in Germany. A few sports cars have faster 0to60 times, but most don't reach the same top end. Those that do have price tags which are multiples of the S65. Best part of the S65 is that it runs well (and efficiently on one 6-cylinder engine) around town without the need for retuning.
Smokes the competition
Kurt Stephon, 3/4/2006
I bought this 06' S-65AMG around 5 months ago. I have to admit I drove everything from the quattroporte to the BMW 760 to the Bentley Continental Flying Spurt and this Benz cleans house. I have around 13k miles already and have taken about 5 road trips to Texas back to St. Louis and this car is the smoothest best handling peppy sports seadan out there. As far as speed I managed to hit 140 MPH and was it ever smooth! Consider the S-class over your average Bimmer!
2006 S65 - First and LAST Mercedes I'll ever own!
VinnyT, 11/9/2017
This car is junk. The previous owner had at least $14000 in repair bills for things that should not break before 60000 miles. I myself have spent $5000 on the suspension system. Well, it failed AGAIN last night. It only has 85000 miles on it now. No more. Having the bank tow the POS away. This car was $172000 brand new and you would think they would build in quality. No. It is a money pit. These are the things that had to be repaired by the previous owner and myself: Ignition coils, seat tracks(3 times), brake rotors, wheels(3 times), battery, (3 times), several struts, and other items that are NOT basic maintenance. BEWARE of these vehicles. It will bleed you dry of funds and the resale is in the toilet. Mercedes should be ashamed of selling such a unreliable piece of crap.
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Features & Specs

11 city / 18 hwy
Seats 5
5-speed shiftable automatic
604 hp @ 4800 rpm
See all Used 2006 Mercedes-Benz S-Class S65 AMG features & specs
More about the 2006 Mercedes-Benz S-Class
Used 2006 Mercedes-Benz S-Class S65 AMG Overview

The Used 2006 Mercedes-Benz S-Class S65 AMG is offered in the following styles: , and S65 AMG 4dr Sedan (6.0L 12cyl Turbo 5A).

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