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869 listings
- $51,013MSRP $51,013
- Exterior color: Cloudburst GrayCloudburst Gray
- Interior color: Glazed Caramel leatheretteGlazed Caramel leatherette
- 19 City / 26 Hwy MPG
- Fields Lexus Glenview (275 mi away)(5)
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Located in Glenview, IL / 275 miles away from Saint Charles, MO
Gray 2025 Lexus IS 350 F SPORT Design AWD 6-Speed Automatic 3.5L V6 DOHC Dual VVT-i 24VLexus Glenview is very proud to offer this wonderful 2025 Lex...
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: JTHBZ1E22S5040910
Stock: L251045
Listed since: 06-11-2025 - $61,043MSRP $61,043
- Exterior color: IncognitoIncognito
- Interior color: Black leatheretteBlack leatherette
- 20 City / 28 Hwy MPG
- Lexus of Highland Park (281 mi away)
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Located in Highland Park, IL / 281 miles away from Saint Charles, MO
Incognito 2025 Lexus IS 350 F SPORT RWD 8-Speed Automatic 3.5L V6 DOHC Dual VVT-i 24VRecent Arrival! 20/28 City/Highway MPGLexus of Highland Park...
Features and Specs:
23 Combined MPG (20 City/28 Highway)
Listing Information:
VIN: JTHGZ1B22S5083881
Stock: P8191
Listed since: 07-07-2025 - New Listing$51,778MSRP $51,778
- Exterior color: Ultrasonic Blue Mica 2.0Ultrasonic Blue Mica 2.0
- Interior color: Circuit Red leatheretteCircuit Red leatherette
- 19 City / 26 Hwy MPG
- Lexus of Highland Park (281 mi away)
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Located in Highland Park, IL / 281 miles away from Saint Charles, MO
Blue 2025 Lexus IS 350 F SPORT AWD 6-Speed Automatic 3.5L V6 DOHC Dual VVT-i 24VRecent Arrival! 19/26 City/Highway MPGLexus of Highland Park is a...
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: JTHGZ1E29S5041297
Stock: 250874
Listed since: 07-18-2025 - Arriving Soon$51,893MSRP $52,643
- Exterior color: Ultrasonic Blue Mica 2.0Ultrasonic Blue Mica 2.0
- Interior color: Black leatheretteBlack leatherette
- 19 City / 26 Hwy MPG
- Lexus of Milwaukee (334 mi away)
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Located in Milwaukee, WI / 334 miles away from Saint Charles, MO
Available at Lexus of MilwaukeeSUMMER SALES EVENT GOING ON NOW!!!The perfect blend of sport and comfort. You deserve to drive something fun and comf...
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: JTHBZ1E20S5041134
Stock: S124DC85
Listed since: 06-12-2025 - Arriving Soon$55,825MSRP $56,575
- Exterior color: IncognitoIncognito
- Interior color: Circuit Red leatheretteCircuit Red leatherette
- 19 City / 26 Hwy MPG
- Lexus of Milwaukee (334 mi away)
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Located in Milwaukee, WI / 334 miles away from Saint Charles, MO
SUMMER SALES EVENT GOING ON NOW!!!The perfect blend of sport and comfort. You deserve to drive something fun and comfortable. The Lexus IS 350 provid...
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: JTHGZ1E25S5041281
Stock: S126DB07
Listed since: 06-23-2025 - $50,363MSRP $51,113
- Exterior color: Ultra WhiteUltra White
- Interior color: Glazed Caramel leatheretteGlazed Caramel leatherette
- 19 City / 26 Hwy MPG
- Lexus of Milwaukee (334 mi away)
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Located in Milwaukee, WI / 334 miles away from Saint Charles, MO
SUMMER SALES EVENT GOING ON NOW!!!The perfect blend of sport and comfort. You deserve to drive something fun and comfortable. The Lexus IS 350 provid...
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: JTHBZ1E2XS5040749
Stock: L21043
Listed since: 07-07-2025 - $52,998MSRP $54,970
- Exterior color: Ultrasonic Blue Mica 2.0Ultrasonic Blue Mica 2.0
- Interior color: Circuit Red leatheretteCircuit Red leatherette
- 19 City / 26 Hwy MPG
- Lexus of Wichita (364 mi away)
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Located in Wichita, KS / 364 miles away from Saint Charles, MO
Delivers 26 Highway MPG and 19 City MPG! This Lexus IS boasts a 3.5L V6 DOHC Dual VVT-i 24V engine powering this Automatic transmission. Front And Rea...
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: JTHGZ1E24S5040879
Stock: 54L1337N
Listed since: 07-10-2025 - $53,568MSRP $53,568
- Exterior color: IncognitoIncognito
- Interior color: Black leatheretteBlack leatherette
- 19 City / 26 Hwy MPG
- Lexus of Wichita (364 mi away)
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Located in Wichita, KS / 364 miles away from Saint Charles, MO
Scores 26 Highway MPG and 19 City MPG! This Lexus IS boasts a 3.5L V6 DOHC Dual VVT-i 24V engine powering this Automatic transmission. Front And Rear ...
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: JTHGZ1E21S5041066
Stock: 54L1401N
Listed since: 07-20-2025 - New Listing$69,045MSRP $69,045
- Exterior color: Ultra WhiteUltra White
- 17 City / 25 Hwy MPG
- Lexus of Wichita (364 mi away)
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Located in Wichita, KS / 364 miles away from Saint Charles, MO
Delivers 25 Highway MPG and 17 City MPG! This Lexus IS boasts a 5.0L V8 DOHC 32V engine powering this Automatic transmission. Rear-Wheel Drive, Front ...
Features and Specs:
20 Combined MPG (17 City/25 Highway)
Listing Information:
VIN: JTHAP1D29S5008040
Stock: 54L1447N
Listed since: 07-20-2025 - $56,193MSRP $56,193
- Exterior color: Ultra WhiteUltra White
- Interior color: Black leatheretteBlack leatherette
- 19 City / 26 Hwy MPG
- Lexus of Wichita (364 mi away)
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Located in Wichita, KS / 364 miles away from Saint Charles, MO
Scores 26 Highway MPG and 19 City MPG! This Lexus IS delivers a 3.5L V6 DOHC Dual VVT-i 24V engine powering this Automatic transmission. Front And Rea...
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: JTHGZ1E28S5041131
Stock: 54L1453N
Listed since: 07-20-2025 - $54,995MSRP $54,995
- Exterior color: Cloudburst GrayCloudburst Gray
- Interior color: Black leatheretteBlack leatherette
- 19 City / 26 Hwy MPG
- Lexus of Wichita (364 mi away)
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Located in Wichita, KS / 364 miles away from Saint Charles, MO
Delivers 26 Highway MPG and 19 City MPG! This Lexus IS delivers a 3.5L V6 DOHC Dual VVT-i 24V engine powering this Automatic transmission. Front And R...
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: JTHGZ1E21S5041018
Stock: 54L1361N
Listed since: 07-20-2025 - $52,025MSRP $52,025
- Exterior color: CaviarCaviar
- Interior color: Black leatheretteBlack leatherette
- 19 City / 26 Hwy MPG
- Lexus of Wichita (364 mi away)
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Located in Wichita, KS / 364 miles away from Saint Charles, MO
Delivers 26 Highway MPG and 19 City MPG! This Lexus IS boasts a 3.5L V6 DOHC Dual VVT-i 24V engine powering this Automatic transmission. Front And Rea...
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: JTHGZ1E24S5041059
Stock: 54L1391N
Listed since: 07-20-2025 - $51,720MSRP
- Exterior color: CaviarCaviar
- Interior color: Black leatheretteBlack leatherette
- 20 City / 28 Hwy MPG
- Lexus of Knoxville (407 mi away)
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Located in Knoxville, TN / 407 miles away from Saint Charles, MO
Caviar 2025 Lexus IS 350 F SPORT RWD 8-Speed Automatic 3.5L V6 DOHC Dual VVT-i 24V **FULLY SERVICED BY A FACTORY TRAINED TECHNICIAN.20/28 City/Highway...
Features and Specs:
23 Combined MPG (20 City/28 Highway)
Listing Information:
VIN: JTHGZ1B28S5087823
Stock: 2370
Listed since: 06-22-2025 - $46,594MSRP
- Exterior color: CaviarCaviar
- Interior color: Glazed Caramel leatheretteGlazed Caramel leatherette
- 21 City / 31 Hwy MPG
- Lexus of Knoxville (407 mi away)
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Located in Knoxville, TN / 407 miles away from Saint Charles, MO
Caviar 2025 Lexus IS 300 RWD 8-Speed Automatic 2.0L I4 Turbocharged **FULLY SERVICED BY A FACTORY TRAINED TECHNICIAN.21/31 City/Highway MPG
Features and Specs:
25 Combined MPG (21 City/31 Highway)
Listing Information:
VIN: JTHDA1D20S5134544
Stock: 2128
Listed since: 04-19-2025 - Arriving Soon$47,593MSRP
- Exterior color: Ultrasonic Blue Mica 2.0Ultrasonic Blue Mica 2.0
- Interior color: Black leatheretteBlack leatherette
- 20 City / 28 Hwy MPG
- Lexus of Knoxville (407 mi away)
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Located in Knoxville, TN / 407 miles away from Saint Charles, MO
Blue 2025 Lexus IS 350 F SPORT Design RWD 8-Speed Automatic 3.5L V6 DOHC Dual VVT-i 24V **FULLY SERVICED BY A FACTORY TRAINED TECHNICIAN.Recent Arriva...
Features and Specs:
23 Combined MPG (20 City/28 Highway)
Listing Information:
VIN: JTHBZ1B28S5088545
Stock: 2469
Listed since: 07-18-2025 - New Listing$55,238MSRP $55,238
- Exterior color: Ultra WhiteUltra White
- Interior color: Black leatheretteBlack leatherette
- 19 City / 26 Hwy MPG
- Germain Lexus of Easton (421 mi away)(21)
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Located in Columbus, OH / 421 miles away from Saint Charles, MO
AWD Automatic 3.5L V6 DOHC Dual VVT-i 24VRecent Arrival! 19/26 City/Highway MPG2025 Lexus IS 350 F SPORT
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: JTHGZ1E24S5040896
Stock: 51284
Listed since: 07-14-2025 - New Listing$50,543MSRP $50,543
- Exterior color: IncognitoIncognito
- Interior color: Black leatheretteBlack leatherette
- 19 City / 26 Hwy MPG
- Germain Lexus of Easton (421 mi away)(21)
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Located in Columbus, OH / 421 miles away from Saint Charles, MO
Incognito AWD Automatic 3.5L V6 DOHC Dual VVT-i 24VRecent Arrival! 19/26 City/Highway MPG2025 Lexus IS 350 F SPORT Design
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: JTHBZ1E20S5041019
Stock: 51295
Listed since: 07-15-2025 - Arriving Soon$53,062MSRP $54,145
- Exterior color: Ultrasonic Blue Mica 2.0Ultrasonic Blue Mica 2.0
- Interior color: Black leatheretteBlack leatherette
- 19 City / 26 Hwy MPG
- Lexus of Maplewood (453 mi away)
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Located in Maplewood, MN / 453 miles away from Saint Charles, MO
Recent Arrival! 08x1 2025 Lexus IS 4D Sedan 350 F SPORT AWD 6-Speed Automatic 3.5L V6 DOHC Dual VVT-i 24VAWD, Black Artificial Leather.This IS is well...
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: JTHGZ1E21S5041262
Stock: 041262
Listed since: 07-17-2025 - New Listing$58,134MSRP $59,320
- Exterior color: Ultrasonic Blue Mica 2.0Ultrasonic Blue Mica 2.0
- Interior color: Black leatheretteBlack leatherette
- 19 City / 26 Hwy MPG
- Lexus of Maplewood (453 mi away)
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Located in Maplewood, MN / 453 miles away from Saint Charles, MO
Recent Arrival! Blue 2025 Lexus IS 4D Sedan 350 F SPORT AWD 6-Speed Automatic 3.5L V6 DOHC Dual VVT-i 24VAWD, Black Nuluxe Artificial Leather.This IS ...
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: JTHGZ1E21S5039317
Stock: L311072
Listed since: 07-11-2025 - Arriving Soon$50,012MSRP $51,033
- Exterior color: Ultrasonic Blue Mica 2.0Ultrasonic Blue Mica 2.0
- Interior color: Black leatheretteBlack leatherette
- 19 City / 26 Hwy MPG
- Lexus of Maplewood (453 mi away)
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Located in Maplewood, MN / 453 miles away from Saint Charles, MO
Recent Arrival! 08x1 2025 Lexus IS 4D Sedan 350 F SPORT Design AWD 6-Speed Automatic 3.5L V6 DOHC Dual VVT-i 24VAWD, Black Artificial Leather.This IS ...
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: JTHBZ1E2XS5041285
Stock: 041285
Listed since: 07-16-2025 - Arriving Soon$52,322MSRP $53,390
- Exterior color: InfraredInfrared
- Interior color: Black leatheretteBlack leatherette
- 19 City / 26 Hwy MPG
- Lexus of Maplewood (453 mi away)
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Located in Maplewood, MN / 453 miles away from Saint Charles, MO
Recent Arrival! 03t5 2025 Lexus IS 4D Sedan 350 F SPORT AWD 6-Speed Automatic 3.5L V6 DOHC Dual VVT-i 24VAWD, Black Artificial Leather.This IS is well...
Features and Specs:
22 Combined MPG (19 City/26 Highway)
Listing Information:
VIN: JTHGZ1E29S5041137
Stock: 041137
Listed since: 07-09-2025
Showing 22 - 42 out of 869 listings
Consumer Reviews for the Lexus IS
Read recent reviews for the Lexus IS
The last of the V8's
HJP, 01/10/2024
2024 Lexus IS 500 F SPORT Performance Premium 4dr Sedan (5.0L 8cyl 8A)
Just purchased a 2024 IS500 vector blue as soon as I saw it at the dealer. Happy to pay MSRP as this will be a classic. The car is fast and fun to drive and unlike a hard core M3 or AMG it is actually very comfortable as a daily driver, and that V8 sound is SPECTACULAR! This is probably the best looking sports sedan in the market. Some reviews complain about a dated interior, however I … find it comfortable and very high quality, in fact that is one of the reasons Lexus and Toyotas are so reliable, they are not constantly making drastic changes every year but constantly improving on what is already a top notch fit and finish. If you live in an area with winter snow and ice this might not be a good year round car and the only other possible issue is the rear seat is tight so if you transport big and tall people keep the ride short.
| Trim | MPG | Engine | Starting Price |
|---|---|---|---|
| 2025 Lexus IS 350 F SPORT Design 4dr Sedan AWD (3.5L 6cyl 6A) | 19 - 26 | 6-cylinders (gas) | $50,543 |
| 2025 Lexus IS 350 F SPORT 4dr Sedan (3.5L 6cyl 8A) | 20 - 28 | 6-cylinders (gas) | $51,720 |
| 2025 Lexus IS 350 F SPORT 4dr Sedan AWD (3.5L 6cyl 6A) | 19 - 26 | 6-cylinders (gas) | $51,778 |
| 2025 Lexus IS 500 F SPORT Performance 4dr Sedan (5.0L 8cyl 8A) | 17 - 25 | 8-cylinders (gas) | $69,045 |
| 2025 Lexus IS 300 4dr Sedan (2.0L 4cyl Turbo 8A) | 21 - 31 | 4-cylinders (gas) | $46,594 |
| 2025 Lexus IS 350 F SPORT Design 4dr Sedan (3.5L 6cyl 8A) | 20 - 28 | 6-cylinders (gas) | $47,593 |
More about the Lexus IS
Edmunds has 869 New Lexus ISes for sale near you, including a 2025 IS 300 Sedan and a 2025 IS 500 F SPORT Performance Sedan ranging in price from $46,594 to $69,045.
How much is a new 2025 Lexus IS in Saint Charles, MO?
- A new 2025 Lexus IS starts at $46,594 (including destination charge) in Saint Charles, MO. Prices will go up based on the trim level you choose and any options you add. Keep in mind that prices can also vary from one state to another and even from one dealership to the next.
How much does a 2025 Lexus IS Sedan cost in Saint Charles, MO?
- A new 2025 Lexus IS Sedan starts at $46,594 in Saint Charles, MO. Prices will vary depending on what trim level you choose. Each state may have different pricing, so make sure you enter your correct ZIP code on Edmunds.Other versions include:
2025 Lexus IS 500 F SPORT which starts at $69,045.
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