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152 listings
  • Price Drop
    $47,990
    good price
    $3,173 below market
    • 39,628 miles
    • No accidents, 1 owner, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Driveway (In-stock online)
    • Home delivery*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Leather Seats
    Close

    Located in Portland, OR / 931 miles away from San Diego, CA

    CarFax No Accidents Reported,CarFax 1-Owner,Rare Find,Green Vehicle,Apple CarPlay,Back-Up Camera,Blind Spot Monitor,Bluetooth,Brake Assist,Heated Seat...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2JGMDA4NC088098
    Stock: NC088098T
    Certified Pre-Owned: No

  • Price Drop
    $33,990
    fair price
    $335 below market
    • 97,379 miles
    • 1 accident, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Nash Auto (80 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Costa Mesa, CA / 80 miles away from San Diego, CA

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: No

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2YGMDA1MC061048
    Stock: B12007
    Certified Pre-Owned: No

  • $53,991
    good price
    $3,214 below market
    • 15,363 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Mercedes-Benz of Temecula (55 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Leather Seats
    Close

    Located in Temecula, CA / 55 miles away from San Diego, CA

    Looking for a clean, well-cared for 2022 Lexus RX? This is it.The Lexus RX is the benchmark all other SUVs strive to meet. With exceptional power, to...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2JGMDAXNC087618
    Stock: T15787A
    Certified Pre-Owned: No
    Listed since: 06-23-2025

  • $47,492
    good price
    $2,088 below market
    • 26,068 miles
    • No accidents, 1 owner, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Capistrano Valley Toyota (61 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in San Juan Capistrano, CA / 61 miles away from San Diego, CA

    **CAPISTRANO VALLEY TOYOTA SPOTLIGHT**, 3.5L V6 DOHC VVT-i 24V, AWD, Parchment w/NuLuxe Seat Trim.Clean CARFAX.Odometer is 4197 miles below market ave...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA3NC077995
    Stock: 25C2256A
    Certified Pre-Owned: No
    Listed since: 07-01-2025

  • New Listing
    $51,999
    fair price
    $547 below market
    • 17,562 miles
    • No accidents, 2 owners, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Toyota of Poway (15 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Poway, CA / 15 miles away from San Diego, CA

    Nav System, Heated Seats, Moonroof, Hybrid, Power Liftgate, All Wheel Drive, iPod/MP3 Input, Satellite Radio, HEATED WOOD & LEATHER STEERING WHEEL.. P...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA3NC091699
    Stock: T21618
    Certified Pre-Owned: No
    Listed since: 06-15-2025

  • New Listing
    $49,188
    fair price
    $1,432 below market
    • 16,387 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Toyota Place (87 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Garden Grove, CA / 87 miles away from San Diego, CA

    Toyota Place is proud to offer our. 2022 Lexus RX 450h F Sport AWDCARFAX One-Owner. Caviar 12.3" Navigation System w/Mark Levinson Audio, Adaptive Var...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2YGMDA3NC090570
    Stock: T090570
    Certified Pre-Owned: No
    Listed since: 04-30-2025

  • New Listing
    • 29,876 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • CarMax (In-stock online)
    • Transfer available from TX to CA*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Corpus Christi, TX / 1,228 miles away from San Diego, CA

    CarMax values transparency and wants you to love your next car, not settle on it. Certain vehicles may have unrepaired safety recalls. Check nhtsa.gov...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA0NC077999
    Stock: 26403175
    Certified Pre-Owned: No

  • New Listing
    $50,777
    fair price
    $564 below market
    • 17,874 miles
    • No accidents, 1 owner, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Lexus of Woodland Hills (132 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    Close

    Located in Woodland Hills, CA / 132 miles away from San Diego, CA

    450h F Sport ONE OWNER, NAVIGATION, PANORAMIC GLASS ROOF, HEATED & VENTILATED SEATS, MARK LEVINSON SURROUND SYSTEM, BLIND SPOT MONITOR, INTUITIVE PARK...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2YGMDA8NC090855
    Stock: T25L7059
    Certified Pre-Owned: No
    Listed since: 06-23-2025

  • New Listing
    $48,988
    fair price
    $560 below market
    • 21,248 miles
    • No accidents, 1 owner, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Lexus of Glendale (117 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Glendale, CA / 117 miles away from San Diego, CA

    L/Certified! *5.75% for up to 72 months! This good looking, 2022 RX450h with 21,248 miles comes nicely equipped with 8-in touchscreen display, Backup ...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA6NC090255
    Stock: T35420
    Certified Pre-Owned: Yes
    Listed since: 07-09-2025

  • $38,995
    fair price
    $631 below market
    • 33,488 miles
    • No accidents, 3 owners, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Tustin Cadillac (79 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    Close

    Located in Tustin, CA / 79 miles away from San Diego, CA

    Eminent White Pearl exterior and Birch interior. Heated Seats, Sunroof, Navigation, Hybrid, OnStar, All Wheel Drive, Back-Up Camera, Satellite Radio, ...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA0LC048970
    Stock: 4286
    Certified Pre-Owned: No
    Listed since: 05-20-2025

  • New Listing
    $38,995
    fair price
    $458 below market
    • 38,896 miles
    • No accidents, 2 owners, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Newport Lexus (78 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    Close

    Located in Newport Beach, CA / 78 miles away from San Diego, CA

    Moonroof, Nav System, Heated Seats, Satellite Radio, Hybrid, Power Liftgate, All Wheel Drive, iPod/MP3 Input, ACCESSORY PACKAGE, POWER TILT & SLIDE MO...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA9LC047705
    Stock: LC047705
    Certified Pre-Owned: No
    Listed since: 06-23-2025

  • Price Drop
    $47,590
    fair price
    $960 below market
    • 29,821 miles
    • No accidents, 1 owner, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Carvana (In-stock online)
    • Home delivery*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Richmond, VA / 2,238 miles away from San Diego, CA

    At Carvana, we go miles beyond the extra mile. That's why we provide you with a convenient, fast, and hassle-free car buying experience that puts you ...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2JGMDA9NC081163
    Stock: 2003713293
    Certified Pre-Owned: No
    Listed since: 05-07-2025

  • Price Drop
    $43,998
    good price
    $1,688 below market
    • 40,485 miles
    • No accidents, 1 owner, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • CarMax (In-stock online)
    • Transfer available from PA to CA*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    Close

    Located in Mechanicsburg, PA / 2,265 miles away from San Diego, CA

    CarMax values transparency and wants you to love your next car, not settle on it. Certain vehicles may have unrepaired safety recalls. Check nhtsa.gov...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA9NC092307
    Stock: 27459841
    Certified Pre-Owned: No

  • Stock photo**
    $49,991
    fair price
    $1,397 below market
    • 25,487 miles
    • No accidents, 1 owner, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Lexus of Thousand Oaks (140 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Navigation
    • Sunroof/Moonroof
    Close

    Located in Thousand Oaks, CA / 140 miles away from San Diego, CA

    Our wish is to engage you in a lifelong relationship, based on making the most of every moment and exceeding your expectations. every day! From the mo...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA2NC090379
    Stock: C090379T
    Certified Pre-Owned: Yes
    Listed since: 07-12-2025

  • Price Drop
    $40,990
    good price
    $1,693 below market
    • 65,477 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Carvana (In-stock online)
    • Home delivery*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Richmond, VA / 2,238 miles away from San Diego, CA

    At Carvana, we go miles beyond the extra mile. That's why we provide you with a convenient, fast, and hassle-free car buying experience that puts you ...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA2NC073341
    Stock: 2003800121
    Certified Pre-Owned: No
    Listed since: 06-14-2025

    • 23,368 miles
    • No accidents, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Longo Lexus (106 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in El Monte, CA / 106 miles away from San Diego, CA

    - Hybrid!- F Sport Performance Package!- Cold Weather Package!- Navigation System With 12.3 Multimedia Screen- Mark Levinson 15 Speaker Premium Audio ...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2YGMDA5LC056451
    Stock: 2PS2822
    Certified Pre-Owned: No
    Listed since: 06-24-2025

  • New Listing
    • 52,394 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • Carvana (In-stock online)
    • Home delivery*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Dallas, TX / 1,178 miles away from San Diego, CA

    At Carvana, we go miles beyond the extra mile. That's why we provide you with a convenient, fast, and hassle-free car buying experience that puts you ...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2YGMDA8NC086742
    Stock: 2003874190
    Certified Pre-Owned: No
    Listed since: 07-14-2025

  • New Listing
    Stock photo**
    $36,995
    fair price
    $604 below market
    • 53,549 miles
    • No accidents, 1 owner, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Genesis of Ontario (97 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Ontario, CA / 97 miles away from San Diego, CA

    Gray 2020 Lexus RX 450h AWD eCVT 3.5L V6 DOHC VVT-i 24V 3.5L V6 DOHC VVT-i 24V, AWD.Recent Arrival! 31/28 City/Highway MPG

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA4LC046042
    Stock: 85T02933
    Certified Pre-Owned: No
    Listed since: 07-19-2025

  • New Listing
    $38,998
    fair price
    $166 above market
    • 43,888 miles
    • No accidents, 1 owner, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • CarMax Buena Park (94 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Keyless Entry/Start
    • Upgraded Headlights
    Close

    Located in Buena Park, CA / 94 miles away from San Diego, CA

    CarMax values transparency and wants you to love your next car, not settle on it. Certain vehicles may have unrepaired safety recalls. Check nhtsa.gov...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA7LC054412
    Stock: 27616015
    Certified Pre-Owned: No

  • New Listing
    Stock photo**
    $49,991
    fair price
    $826 above market
    • 21,245 miles
    • No accidents, 1 owner, personal use
    • 5 Seats, 31 City / 28 Hwy MPG
    • Lexus of Thousand Oaks (140 mi away)
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Sunroof/Moonroof
    • Keyless Entry/Start
    Close

    Located in Thousand Oaks, CA / 140 miles away from San Diego, CA

    Step into the SoCal lifestyle with the 2022 Lexus RX 450h, where every drive is a perfect mix of luxury, efficiency, and the vibrant energy of the Gol...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA4NC083367
    Stock: C083367T
    Certified Pre-Owned: Yes
    Listed since: 07-14-2025

  • New Listing
    $45,998
    fair price
    $1,479 above market
    • 40,123 miles
    • No accidents, 2 owners, personal use only
    • 5 Seats, 31 City / 28 Hwy MPG
    • CarMax (In-stock online)
    • Transfer available from NC to CA*
    • AWD/4WD
    • Back-up camera
    • Bluetooth
    • Sunroof/Moonroof
    • Keyless Entry/Start
    Close

    Located in Raleigh, NC / 2,186 miles away from San Diego, CA

    CarMax values transparency and wants you to love your next car, not settle on it. Certain vehicles may have unrepaired safety recalls. Check nhtsa.gov...

    AutoCheck Vehicle History Summary

    Accident Free Vehicle: Yes

    Personal Use Only: Yes

    History Provider: AutoCheck

    Title Details: Clean Title

    Salvage Vehicle: No

    Frame Damage: No

    Theft History: No

    Lemon Status: No

    Free History Report: No

    Features and Specs:

    30 Combined MPG (31 City/28 Highway)

    Listing Information:

    VIN: 2T2HGMDA8NC077569
    Stock: 26262259
    Certified Pre-Owned: No

Showing 22 - 42 out of 152 listings

Consumer Reviews for the Lexus RX 450h

Read recent reviews for the Lexus RX 450h
Overall Consumer Rating
4.3 out of 5 stars33 Reviews
Write a vehicle reviewSee all 33 reviews
  • 5 star
    (61%)
  • 4 star
    (21%)
  • 3 star
    (12%)
  • 2 star
    (3%)
  • 1 star
    (3%)
5 out of 5 stars

My Atomic Silver Ride!

markh, 11/25/2019
2020 Lexus RX 450h F SPORT Performance 4dr SUV AWD (3.5L 6cyl gas/electric hybrid CVT)
I graduated from a 2017 RX 350 to the 2020 RX 450h Performance F Sport and love it! I love the feel and sound when I put it in Sport mode, but most of the time I keep it in Eco Mode for improved mileage. In Sport mode the gas pedal is soft, whereas in Eco mode it seems as the pedal is harder to push, saving fuel? The car is very similar to my 2017 inside, except the speedometer … area. There is no space under the back seats to stick my car wash rags or umbrella since the battery is in that area. (not a problem). The RX 450h has a smaller fuel tank then the RX 350 but I am getting around a 100 miles more between fill ups with the RX 450h. The only drawback is the RX 450h does require 93 octane which compared to an RX 350 that burns 87 octane there is only a slight cost savings on fuel. Currently I am getting exactly what the estimated mileage on the sticker says....
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Used 2022 Lexus RX 450h in San Diego, CA Values

Estimated values
2022 Lexus RX 450h 4dr SUV AWD (3.5L 6cyl gas/electric hybrid CVT) with no options
ConditionTrade-InPrivate PartyDealer Retail
Outstanding$35,614$37,109$38,666
Clean$35,140$36,595$38,110
Average$34,349$35,738$37,183
Rough$33,321$34,624$35,979

The average list price of a used 2022 Lexus RX 450h in San Diego, California is $45,468. The average mileage on a used Lexus RX 450h 2022 for sale in San Diego, California is 35,696. Based on the average mileage of 35,696 for used 2022 Lexus RX 450h for sale in San Diego, CA and using an average vehicle condition rating, which means the vehicle may have a few mechanical and/or cosmetic problems and may require a considerable amount of reconditioning, we appraise the average trade-in value of a used Lexus RX 450h 2022 in San Diego, California to be $34,349.

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* Delivery of any kind does not apply to Alaska and Hawaii. Contact the dealer for delivery details, restrictions and costs.