Bought a 2010 RX450h from the Portland, Oregon Lexus dealer a month ago. We've taken it on several 4-hour trips and I've driven it every day on suburban roads with some freeway. Overall about 26mpg regular or diesel, so we'll stick to regular gas in the future. I've noticed that I can nurse the mpg up to perhaps 28mpg by babying my acceleration and braking, but I prefer to drive in my normal fashion; anyway, gas is cheap and saving gas money wasn't the motivator. Pros: beautiful and luxurious. Surprisingly economical. Like a gorgeous woman who still loves tacos and beer. Minuses: Has middle-grade stereo, boomy bass at about 100Hz, (I'm an audio engineer, this really bugs me but what the heck), unknown future battery replacement cost (but other Prius hybrids have lasted for 200k+ miles, plus it's a Toyota/Lexus).
The great thing about this SUV is that the body changes so little each year that the car seems like new, at about a third of the price of a new one. I don't like the big new grilles Lexus has been making anyway, I think they cheapen the look. I prefer the more refined grille of the 2010. Despite that mine had somewhat high mileage, it was extremely well maintained by the previous owner and seems like new. I have had no problems with it thus far except I occasionally get a little carriage squeaking on overpasses for some reason, but not on regular paved road. However, otherwise, the ride is as smooth and quiet as silk. My favorite things about this car are the cushy interior and the high ride so that you can practically walk in and out of the car. No having to bend way down to get into the car. The quality of the interior is great, soft leather, nice wood on steering wheel and other locations. The only things that are cons for me are that the charger outlet and usbs are not in a good place. You have to remove a storage bucket in the front center console to get to them. It would be more convenient to have them in the dashboard area. However I guess it allows you to store things that are being charged or played out of sight. Heated seats are very nice. I like the auto lights and being able to talk on the phone handsfree via bluetooth connected phone. Mine is silver (tungsten pearl, to be precise; it is a little different than silver, I've noticed) with black interior and some light gray around the window area. I love it. Sometimes after I get out of it and walk away, I look back at it just to admire it. I am getting good mileage, averaging about 29 mpg thus far, and that's on 87 or 89. By all means, buy the luxe car a few years later at a fraction of the price!
We have taken very good care of our 2010 Lexus RX450H the past 3 years (second owner). Low miles, no accidents, garaged....ect. We have been looking at the value of our 450H on Edmunds and Kellys.....shock that we are already under loan value. And we put down several thousand at purchase to cover the gap. Very disappointed. And this Hybrid never met it's promised mpg's either.
I've been driving my RX 450H for over 2 years and love it. I'm used to getting a brand new company car every two years and when they limited the selection to just a Ford Focus, I decided to opt out for milage reimbursement instead. I spend a tremendous amount of time driving and wanted something nice/comfortable. We purchased the extra maintenance plan and at 99,500 miles, so far I've done nothing but the scheduled oil/maintenance, covered under my plan. More importantly, I love driving it. I concur that milage is contingent upon driving style. I average 28 mpg even hitting 80mph with highway driving, by avoiding quick acceleration and taking my foot off the accelerator when I know I'm braking soon. My only frustration is the USB port location is ridiculous. Its buried under the storage trays, and access is difficult because the storage compartment doesn't open a full 90 degrees. Thankfully I leave the connector plugged in so rarely have to access it. My Lexus dealership couldn't be more accommodating during maintenance, with a loaner if reserved beforehand, shuttles to the mall across the street if desired, and a nice set up at the dealership where I can work or watch TV in designated lounges. (Johnson Lexus, Raleigh NC) I highly recommend this car and wouldn't hesitate to buy another lexus after this experience.