Bought my ES300 at 83,000 miles. No troubles, absolutely no troubles at all. Never been to the shop at all except for regular maintenance oil changes. At speeds above 75, wind noise gets appreciable higher through the window. The car has lots of pep only when floored. The tranny thinks for about a second before shifting and then the car flies. A very smooth ride and smooth steering. Absolutely disgusting cup holders. I have given up on the floor mat after numerous spills. There is a noticeable body roll during cornering at high speeds, but that's due to the soft suspension bug - again the ride is magnificently soft. If you are looking for a soft, plush, trouble free ride. This is not a sports car.
There are few cars in ones lifetime that one buys that you look back and say to yourself "Why didn't I do this sooner?". The ES300 is one of those cars. Unlike cars we've owned in the past, we enjoy the car *more* the longer we own it. The legendary quality of a Toyota is kicked up a notch with the Lexus. Don't be fooled, this is NOT a rebadged Camry. Having driven/owned both, the only things they share is the same parent company. "The Relentless Pursuit of Perfection". Well, I think Lexus is getting pretty darn close to the finish line."
The Lexus es300 is one of the best cars I've owned. After 8 years I have had no problems with it. It drives smooth and is pretty fast. The seats are comfortable and it's quiet and gets decent fuel economy. (I get about 19/24 mpg.)
I purchased a certified pre-owned 2000 with 33000 miles one month ago. This is my first "luxury" car after always having sports cars. Its a great car, but not without flaws...in my opinion, there is more wind noise than there should be in a car of this caliber (mostly noticeable on the highway or over 55 mph). The only other thing I dislike is the radio/speaker system - "Lexus Premium Sound" is pretty poor. VERY weak bass no matter how you adjust it. If you have an opportunity to get the upgraded Mark Levinson stereo, I'd try it. I was also surprised I can't quite reach 30mpg, even on conservative all- highway trips.