Let's face, large vans are purely utilitarian vehicles. However, if you need one for whatever reason, Ford makes a far better product than its competitors. This is true whether the yardstick is reliability, drivability, build quality or passenger comfort.
I purchased a 2004 E250 Cargo van in 2006 when I began my mobile automotive repair business. It had 29K miles when I bought it. I used it daily and it was very reliable. 3 years of hard driving and it only needed brakes, oil changes, wiper blades and a drive belt. Unfortunately, I was involved in a head on collision and the van was totaled with 60K miles. I walked away from the accident with a broken bone in my foot, and torn ligaments as well, but otherwise intact. They are great vans and I highly recommend them and a bulkhead if you are carrying tools.
Handles and drives like a large car not a truck. I love the mirrors for changing lanes and backing. Many trips made between Atlanta and Ft. Lauderdale. Only complaint is the wind noise. No problems from day one.