In comparison, the 2016 Town & Country delivers a rating of 17 mpg on city driving, 25 mpg on the highway and 20 mpg combined, the EPA said.
The Pacifica is equipped with a revised 3.6-liter Pentastar V6 engine and a nine-speed automatic transmission, the first in a minivan.
Fuel economy is improved through reduced body weight, a new variable valve timing system with two operating modes and the new transmission.
An engine stop-start system will debut on the Pacifica later this year and should improve the vehicle's fuel economy even further.
In addition, the 2017 Pacifica Hybrid arrives at dealerships in the second half of the year.
Fiat-Chrysler said it will deliver an estimated range of 30 miles in electric mode. It is expected to achieve an efficiency rating of 80 MPG equivalent.
The Pacifica will arrive at dealerships at a time of low gas prices.
The AAA Daily Fuel Gauge Report on Wednesday pegged the average price for a gallon of unleaded gasoline at $1.82, compared to $2.45 a year ago.
Edmunds says: Car shoppers who are concerned about pump prices get some reassuring news about the Chrysler Pacifica, which ties the Odyssey for highway fuel economy honors.