The pricing reflects a $300 increase over the 2015 ES 350.
They include a bolder, chrome-trimmed spindle grille, LED headlights, a new front fascia and L-themed taillights.
New exterior colors include Autumn Shimmer, Nightfall Mica, Caviar and Eminent White Pearl.
New cabin trims include Linear Dark Mocha wood and Bamboo with a matte finish.
A Mark Levinson premium sound system and panoramic roof are now available with all option packages.
Lexus Enform Safety Connect is standard on all 2016 ES 350 cars with access to Lexus Enform response centers.
The 2016 ES 350 is equipped with a standard 268-horsepower 3.5-liter V6 engine linked to a six-speed automatic transmission.
Edmunds says: The modest price increase on the 2016 Lexus ES 350 reflects the makeover and added features.