The rating applies to 2016 F-150 Regular Cab and SuperCrew models in 4x2 and 4x4 configurations.
On sale now at Ford dealerships, the 2016 F-150 received five stars in the front and side crash tests and four stars in the rollover crash test.
The 2016 F-250 SuperCab has not been rated.
Standard safety features on the 2016 F-150 include antilock brakes, stability and traction control, trailer sway control, front-seat side-impact airbags and full-length side curtain airbags.
Optional F-150 safety equipment includes curve control, adaptive cruise control and a blind-spot information system.
The Insurance Institute for Highway Safety has not rated the 2016 F-150.
Edmunds says: Safety-minded truck shoppers should note that the 2016 Chevrolet Silverado also earned the highest five-star safety rating from NHTSA. The 2016 Nissan Titan has not been rated. The 2016 Ram 1500 and Toyota Tundra earned a four-star overall safety rating.