Have put about 700 miles on my new 2010 Sienna. Traded in a 02 Odyssey. The car is very quiet, good handling, great controls, smooth drive. Got the stereo JBL option - great sound (kids love it, too). Much quieter than the Odyssey and its the AWD is a great seller.
Quiet drive, controls, 2d seats flip forward for easy access to the back, auto doors (sides and back), lots of lights, plugs, moon roof, storage space.
Seats not as deep or wide as Odyssey, therefore not as comfortable.