I purchased my Highlander in November 2009. 48k miles later and she still drives like she did off of the lot. Plenty of cargo space to accommodate our family of 4. Enough acceleration to make merging onto any freeway a breeze. It's average around 20 mpg. The interior of the car has held up very well. Plenty of room and head clearance (I'm 6'3"). Quiet and soft ride. It handles much like a Camry. We've had no problems, other than the tires wearing out
at 30k miles. Put some Michelin tires on and they haven't had any wear after 18k miles. I do wish it had an outside temp reading on the dash. The 3rd row is very cramped, and hard to get to, but we don't really need it anyways.
Reliability, v6 engine with plenty of power, decent fuel economy considering the engine and size, stow away seat, plenty of cup holders, cargo power outlet
Better access to the 3rd row, outside temp reading