I bought my camry used in 02 with 54k already on it. I've added 40k miles cross country and up and down the East coast. The water pump broke at about 70k miles and took out the timing belt ($400 to repair), but otherwise I've not had any problems. I'd definitely buy the V6 - mine's a 4-cylinder and is fine for regular driving but doesn't have much of any reserves of power when you need it. I find the seats very comfortable and I love the interior layout. The fuel economy is great, too - I can go over 500 miles on one tank on the highway (I've gotten as much as 33 mpg).
Interior layout & comfort, quiet ride, great fuel economy.