I bought a 2004 Xterra brand new and it was a great car until a patch of black ice and a telephone pole last week. Very safe vehicle, as I was uninjured from the crash. I had racked up close to 170,000 miles without any major issues, just your usual suspects (brakes, tires, etc.). Engine and transmission were still running great. The only thing I had noticed was the heater/AC blower motor would only work on high (seems to be a recurring Nissan problem, I've had it happen to 2 other Nissans). Other than that, a great car! I'm seriously considering buying another one to replace it.
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